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Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2.
J Infect. 2020 04; 80(4):394-400.JI

Abstract

PURPOSE

To investigate the clinical and imaging characteristics of computed tomography (CT) in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2.

MATERIALS AND METHODS

A retrospective analysis was performed on the imaging findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. The clinical and imaging data were analyzed.

RESULTS

Fifty patients were enrolled, including mild type in nine, common in 28, severe in 10 and critically severe in the rest three. Mild patients (29 years) were significantly (P<0.03) younger than either common (44.5 years) or severe (54.7) and critically severe (65.7 years) patients, and common patients were also significantly (P<0.03) younger than severe and critically severe patients. Mild patients had low to moderate fever (<39.1 °C), 49 (98%) patients had normal or slightly reduced leukocyte count, 14 (28%) had decreased counts of lymphocytes, and 26 (52%) patients had increased C-reactive protein. Nine mild patients were negative in CT imaging. For all the other types of NCP, the lesion was in the right upper lobe in 30 cases, right middle lobe in 22, right lower lobe in 39, left upper lobe in 33 and left lower lobe in 36. The lesion was primarily located in the peripheral area under the pleura with possible extension towards the pulmonary hilum. Symmetrical lesions were seen in 26 cases and asymmetrical in 15. The density of lesion was mostly uneven with ground glass opacity as the primary presentation accompanied by partial consolidation and fibrosis.

CONCLUSION

CT imaging presentations of NCP are mostly patchy ground glass opacities in the peripheral areas under the pleura with partial consolidation which will be absorbed with formation of fibrotic stripes if improved. CT scanning provides important bases for early diagnosis and treatment of NCP.

Authors+Show Affiliations

Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing 100039, China.Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing 100039, China.Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing 100039, China.Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing 100039, China. Electronic address: 15001008285@139.com.CT/MRI Room, Affiliated Hospital of Hebei University, 212 Eastern Yuhua Road, Baoding, Hebei Province 071000, China. Electronic address: yinxiaoping78@sina.com.Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing 100039, China.Department of Radiology, Baoding City People's Hospital, Baoding, Hebei Province 071000, China.CT/MRI Room, Affiliated Hospital of Hebei University, 212 Eastern Yuhua Road, Baoding, Hebei Province 071000, China.Clinical College, Hebei University, Boding, Hebei Province, China.Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing 100039, China. Electronic address: browngao@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32109443

Citation

Xu, Yu-Huan, et al. "Clinical and Computed Tomographic Imaging Features of Novel Coronavirus Pneumonia Caused By SARS-CoV-2." The Journal of Infection, vol. 80, no. 4, 2020, pp. 394-400.
Xu YH, Dong JH, An WM, et al. Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. J Infect. 2020;80(4):394-400.
Xu, Y. H., Dong, J. H., An, W. M., Lv, X. Y., Yin, X. P., Zhang, J. Z., Dong, L., Ma, X., Zhang, H. J., & Gao, B. L. (2020). Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. The Journal of Infection, 80(4), 394-400. https://doi.org/10.1016/j.jinf.2020.02.017
Xu YH, et al. Clinical and Computed Tomographic Imaging Features of Novel Coronavirus Pneumonia Caused By SARS-CoV-2. J Infect. 2020;80(4):394-400. PubMed PMID: 32109443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. AU - Xu,Yu-Huan, AU - Dong,Jing-Hui, AU - An,Wei-Min, AU - Lv,Xiao-Yan, AU - Yin,Xiao-Ping, AU - Zhang,Jian-Zeng, AU - Dong,Li, AU - Ma,Xi, AU - Zhang,Hong-Jie, AU - Gao,Bu-Lang, Y1 - 2020/02/25/ PY - 2020/02/19/received PY - 2020/02/21/accepted PY - 2020/2/29/pubmed PY - 2020/4/9/medline PY - 2020/2/29/entrez KW - Computed tomography KW - Covid-19 KW - Imaging finding KW - Novel coronavirus pneumonia KW - SARS-CoV-2 SP - 394 EP - 400 JF - The Journal of infection JO - J Infect VL - 80 IS - 4 N2 - PURPOSE: To investigate the clinical and imaging characteristics of computed tomography (CT) in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2. MATERIALS AND METHODS: A retrospective analysis was performed on the imaging findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. The clinical and imaging data were analyzed. RESULTS: Fifty patients were enrolled, including mild type in nine, common in 28, severe in 10 and critically severe in the rest three. Mild patients (29 years) were significantly (P<0.03) younger than either common (44.5 years) or severe (54.7) and critically severe (65.7 years) patients, and common patients were also significantly (P<0.03) younger than severe and critically severe patients. Mild patients had low to moderate fever (<39.1 °C), 49 (98%) patients had normal or slightly reduced leukocyte count, 14 (28%) had decreased counts of lymphocytes, and 26 (52%) patients had increased C-reactive protein. Nine mild patients were negative in CT imaging. For all the other types of NCP, the lesion was in the right upper lobe in 30 cases, right middle lobe in 22, right lower lobe in 39, left upper lobe in 33 and left lower lobe in 36. The lesion was primarily located in the peripheral area under the pleura with possible extension towards the pulmonary hilum. Symmetrical lesions were seen in 26 cases and asymmetrical in 15. The density of lesion was mostly uneven with ground glass opacity as the primary presentation accompanied by partial consolidation and fibrosis. CONCLUSION: CT imaging presentations of NCP are mostly patchy ground glass opacities in the peripheral areas under the pleura with partial consolidation which will be absorbed with formation of fibrotic stripes if improved. CT scanning provides important bases for early diagnosis and treatment of NCP. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/32109443/Clinical_and_computed_tomographic_imaging_features_of_novel_coronavirus_pneumonia_caused_by_SARS_CoV_2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(20)30100-6 DB - PRIME DP - Unbound Medicine ER -