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Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent.
Case Rep Neurol. 2020 Jan-Apr; 12(1):50-55.CR

Abstract

Paraneoplastic neurological syndromes (PNS) associated with anti-CV2/CRMP5 antibodies are rare in the literature. Various clinical manifestations can occur including paraneoplastic limbic encephalitis (PLE). Thymoma is one of the rare causes that can be associated with this syndrome. It has not been reported in the literature in children or adolescents to the best of our knowledge. We report a case of PLE in a 19-year-old male patient secondary to thymoma that was diagnosed after 5 years of onset. Anti-CV2/CRMP5 antibodies were positive in the serum and became negative after thymectomy. Diagnosis of PNS should be evoked in cases with atypical neurological manifestation and can be confirmed by the presence of onconeuronal antibodies. We report the first pediatric PLE secondary to thymoma associated with anti-CV2/CRMP5 antibodies.

Authors+Show Affiliations

Department of Neurology, Ibn Sina Hospital, Safat, Kuwait.Department of Neurology, Ibn Sina Hospital, Safat, Kuwait.Department of Neurology, Ibn Sina Hospital, Safat, Kuwait.Department of Neurology, Ibn Sina Hospital, Safat, Kuwait. Department of Medicine, Faculty of Medicine, Health Sciences Centre, Kuwait University, Kuwait City, Kuwait.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32110228

Citation

Ibrahim Ismail, Ismail, et al. "Paraneoplastic Limbic Encephalitis Associated With Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent." Case Reports in Neurology, vol. 12, no. 1, 2020, pp. 50-55.
Ibrahim Ismail I, K John J, Ibrahim M, et al. Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent. Case Rep Neurol. 2020;12(1):50-55.
Ibrahim Ismail, I., K John, J., Ibrahim, M., & Al-Hashel, J. Y. (2020). Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent. Case Reports in Neurology, 12(1), 50-55. https://doi.org/10.1159/000505232
Ibrahim Ismail I, et al. Paraneoplastic Limbic Encephalitis Associated With Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent. Case Rep Neurol. 2020 Jan-Apr;12(1):50-55. PubMed PMID: 32110228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraneoplastic Limbic Encephalitis Associated with Anti-CV2/CRMP5 Antibodies Secondary to Thymoma in an Adolescent. AU - Ibrahim Ismail,Ismail, AU - K John,John, AU - Ibrahim,Mohamed, AU - Al-Hashel,Jasem Yousef, Y1 - 2020/02/05/ PY - 2019/10/23/received PY - 2019/12/03/accepted PY - 2020/2/29/entrez PY - 2020/2/29/pubmed PY - 2020/2/29/medline KW - CRMP5 KW - CV2 KW - Limbic encephalitis KW - Onconeuronal antibodies KW - Paraneoplastic syndromes KW - Thymoma SP - 50 EP - 55 JF - Case reports in neurology JO - Case Rep Neurol VL - 12 IS - 1 N2 - Paraneoplastic neurological syndromes (PNS) associated with anti-CV2/CRMP5 antibodies are rare in the literature. Various clinical manifestations can occur including paraneoplastic limbic encephalitis (PLE). Thymoma is one of the rare causes that can be associated with this syndrome. It has not been reported in the literature in children or adolescents to the best of our knowledge. We report a case of PLE in a 19-year-old male patient secondary to thymoma that was diagnosed after 5 years of onset. Anti-CV2/CRMP5 antibodies were positive in the serum and became negative after thymectomy. Diagnosis of PNS should be evoked in cases with atypical neurological manifestation and can be confirmed by the presence of onconeuronal antibodies. We report the first pediatric PLE secondary to thymoma associated with anti-CV2/CRMP5 antibodies. SN - 1662-680X UR - https://www.unboundmedicine.com/medline/citation/32110228/Paraneoplastic_Limbic_Encephalitis_Associated_with_Anti_CV2/CRMP5_Antibodies_Secondary_to_Thymoma_in_an_Adolescent_ L2 - https://www.karger.com?DOI=10.1159/000505232 DB - PRIME DP - Unbound Medicine ER -
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