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The role of HPA-axis function during pregnancy in the intergenerational transmission of maternal adverse childhood experiences to child behavior problems.
Dev Psychopathol. 2021 02; 33(1):284-300.DP

Abstract

The current study aimed to understand the mediating and/or moderating role of prenatal hypothalamic-pituitary-adrenal (HPA) axis function in the association between maternal adverse childhood experiences (ACEs) and child internalizing and externalizing behavior problems at age 4. The influence of timing and child sex were also explored. Participants were 248 mother-child dyads enrolled in a prospective longitudinal cohort study (the Alberta Pregnancy Outcomes and Nutrition Study). Maternal ACEs were retrospectively assessed while maternal self-reported depression and diurnal salivary cortisol were assessed prospectively at 6-26 weeks gestation (T1) and 27-37 weeks gestation (T2). Maternal report of child internalizing and externalizing problems was assessed at 4 years (T3). Results revealed that there was a negative indirect association between maternal ACEs and child internalizing behavior via a higher maternal cortisol awakening response (CAR). Maternal diurnal cortisol slope moderated the association between maternal ACEs and child behavior problems. Some of these effects were dependent on child sex, such that higher ACEs and a flatter diurnal slope at T1 was associated with more internalizing behavior in female children and more externalizing behavior in male children. There were timing effects such that the mediating and moderating effects were strongest at T1.

Authors+Show Affiliations

Department of Psychology, University of Calgary, Calgary, AB, Canada. Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada.Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. Faculty of Nursing & Cumming School of Medicine (Pediatrics, Psychiatry & Community Health Sciences), University of Calgary, Calgary, AB, Canada.Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. Department of Pediatrics, University of Calgary, Calgary, AB, Canada. Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.Department of Psychology, University of Calgary, Calgary, AB, Canada.Department of Psychology, University of Calgary, Calgary, AB, Canada. Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. Department of Pediatrics, University of Calgary, Calgary, AB, Canada. Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32124709

Citation

Thomas-Argyriou, Jenna C., et al. "The Role of HPA-axis Function During Pregnancy in the Intergenerational Transmission of Maternal Adverse Childhood Experiences to Child Behavior Problems." Development and Psychopathology, vol. 33, no. 1, 2021, pp. 284-300.
Thomas-Argyriou JC, Letourneau N, Dewey D, et al. The role of HPA-axis function during pregnancy in the intergenerational transmission of maternal adverse childhood experiences to child behavior problems. Dev Psychopathol. 2021;33(1):284-300.
Thomas-Argyriou, J. C., Letourneau, N., Dewey, D., Campbell, T. S., & Giesbrecht, G. F. (2021). The role of HPA-axis function during pregnancy in the intergenerational transmission of maternal adverse childhood experiences to child behavior problems. Development and Psychopathology, 33(1), 284-300. https://doi.org/10.1017/S0954579419001767
Thomas-Argyriou JC, et al. The Role of HPA-axis Function During Pregnancy in the Intergenerational Transmission of Maternal Adverse Childhood Experiences to Child Behavior Problems. Dev Psychopathol. 2021;33(1):284-300. PubMed PMID: 32124709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of HPA-axis function during pregnancy in the intergenerational transmission of maternal adverse childhood experiences to child behavior problems. AU - Thomas-Argyriou,Jenna C, AU - Letourneau,Nicole, AU - Dewey,Deborah, AU - Campbell,Tavis S, AU - Giesbrecht,Gerald F, AU - ,, PY - 2020/3/4/pubmed PY - 2021/4/28/medline PY - 2020/3/4/entrez KW - HPA axis KW - adverse childhood experiences KW - child behavior KW - intergenerational transmission of stress KW - pregnancy SP - 284 EP - 300 JF - Development and psychopathology JO - Dev Psychopathol VL - 33 IS - 1 N2 - The current study aimed to understand the mediating and/or moderating role of prenatal hypothalamic-pituitary-adrenal (HPA) axis function in the association between maternal adverse childhood experiences (ACEs) and child internalizing and externalizing behavior problems at age 4. The influence of timing and child sex were also explored. Participants were 248 mother-child dyads enrolled in a prospective longitudinal cohort study (the Alberta Pregnancy Outcomes and Nutrition Study). Maternal ACEs were retrospectively assessed while maternal self-reported depression and diurnal salivary cortisol were assessed prospectively at 6-26 weeks gestation (T1) and 27-37 weeks gestation (T2). Maternal report of child internalizing and externalizing problems was assessed at 4 years (T3). Results revealed that there was a negative indirect association between maternal ACEs and child internalizing behavior via a higher maternal cortisol awakening response (CAR). Maternal diurnal cortisol slope moderated the association between maternal ACEs and child behavior problems. Some of these effects were dependent on child sex, such that higher ACEs and a flatter diurnal slope at T1 was associated with more internalizing behavior in female children and more externalizing behavior in male children. There were timing effects such that the mediating and moderating effects were strongest at T1. SN - 1469-2198 UR - https://www.unboundmedicine.com/medline/citation/32124709/The_role_of_HPA_axis_function_during_pregnancy_in_the_intergenerational_transmission_of_maternal_adverse_childhood_experiences_to_child_behavior_problems_ L2 - https://www.cambridge.org/core/product/identifier/S0954579419001767/type/journal_article DB - PRIME DP - Unbound Medicine ER -