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Do toxicokinetic and toxicodynamic processes hold the same for light and heavy rare earth elements in terrestrial organism Enchytraeus crypticus?
Environ Pollut. 2020 Jul; 262:114234.EP

Abstract

The widespread use of rare earth elements (REEs) in numerous sectors have resulted in their release into the environment. Existing knowledge about the effects of REEs were acquired mainly based on toxicity tests with aquatic organisms and a fixed exposure time, Here, the dynamic accumulation and toxicity of REEs (La, Ce, and Gd) in soil organism Enchytraeus crypticus were determined and modeled by a first-order one-compartment model and a time-toxicity logistic model, respectively. Generally, the accumulation and toxicity of REEs were both exposure level- and time-dependent. The overall uptake rate constants were 2.97, 2.48, and 2.38 L kg-1d-1 for La, Ce, and Gd, respectively. The corresponding elimination rate constants were 0.99, 0.78, and 0.56 d-1, respectively. The worms exhibited faster uptake and elimination ability for light REEs (La and Ce) than for heavy REEs (Gd). For all three REEs, the LC50 values based on exposure concentrations decreased with time and reached ultimate values after approximately 10 d exposure. The estimated ultimate LC50 values (LC50∞) were 279, 334, and 358 mg L-1 for Ce, Gd, and La, respectively. When expressed as body concentration, the LC50inter value was almost constant with time, demonstrating that internal body concentration could be a better indicator of dynamic toxicity of REEs than external dose. This study highlights that specific REE and exposure time should be taken into account in accurately assessing risk of REEs.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Huang X
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
He E
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: heerk@mail.sysu.edu.cn.
Qiu H
School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China; Guangdong Provincial Key Lab for Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510006, China.
Zhang L
South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China.
Tang Y
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Provincial Key Lab for Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510006, China.
Zhao C
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Provincial Key Lab for Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510006, China.
Li M
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
Xiao X
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China.
Qiu R
School of Environmental Science and Engineering, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Provincial Key Lab for Environmental Pollution Control and Remediation Technology, Sun Yat-sen University, Guangzhou, 510006, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agriculture University, Guangzhou, 510642, China.

MeSH

AnimalsMetals, Rare EarthOligochaetaSoilSoil PollutantsToxicokinetics

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32126438

Citation

Huang, Xueying, et al. "Do Toxicokinetic and Toxicodynamic Processes Hold the Same for Light and Heavy Rare Earth Elements in Terrestrial Organism Enchytraeus Crypticus?" Environmental Pollution (Barking, Essex : 1987), vol. 262, 2020, p. 114234.
Huang X, He E, Qiu H, et al. Do toxicokinetic and toxicodynamic processes hold the same for light and heavy rare earth elements in terrestrial organism Enchytraeus crypticus? Environ Pollut. 2020;262:114234.
Huang, X., He, E., Qiu, H., Zhang, L., Tang, Y., Zhao, C., Li, M., Xiao, X., & Qiu, R. (2020). Do toxicokinetic and toxicodynamic processes hold the same for light and heavy rare earth elements in terrestrial organism Enchytraeus crypticus? Environmental Pollution (Barking, Essex : 1987), 262, 114234. https://doi.org/10.1016/j.envpol.2020.114234
Huang X, et al. Do Toxicokinetic and Toxicodynamic Processes Hold the Same for Light and Heavy Rare Earth Elements in Terrestrial Organism Enchytraeus Crypticus. Environ Pollut. 2020;262:114234. PubMed PMID: 32126438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Do toxicokinetic and toxicodynamic processes hold the same for light and heavy rare earth elements in terrestrial organism Enchytraeus crypticus? AU - Huang,Xueying, AU - He,Erkai, AU - Qiu,Hao, AU - Zhang,Lulu, AU - Tang,Yetao, AU - Zhao,Chunmei, AU - Li,Min, AU - Xiao,Xue, AU - Qiu,Rongliang, Y1 - 2020/02/20/ PY - 2019/12/11/received PY - 2020/02/10/revised PY - 2020/02/17/accepted PY - 2020/3/4/pubmed PY - 2020/7/11/medline PY - 2020/3/4/entrez KW - Accumulation KW - Dynamic KW - REEs KW - TK-TD process KW - Toxicity SP - 114234 EP - 114234 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 262 N2 - The widespread use of rare earth elements (REEs) in numerous sectors have resulted in their release into the environment. Existing knowledge about the effects of REEs were acquired mainly based on toxicity tests with aquatic organisms and a fixed exposure time, Here, the dynamic accumulation and toxicity of REEs (La, Ce, and Gd) in soil organism Enchytraeus crypticus were determined and modeled by a first-order one-compartment model and a time-toxicity logistic model, respectively. Generally, the accumulation and toxicity of REEs were both exposure level- and time-dependent. The overall uptake rate constants were 2.97, 2.48, and 2.38 L kg-1d-1 for La, Ce, and Gd, respectively. The corresponding elimination rate constants were 0.99, 0.78, and 0.56 d-1, respectively. The worms exhibited faster uptake and elimination ability for light REEs (La and Ce) than for heavy REEs (Gd). For all three REEs, the LC50 values based on exposure concentrations decreased with time and reached ultimate values after approximately 10 d exposure. The estimated ultimate LC50 values (LC50∞) were 279, 334, and 358 mg L-1 for Ce, Gd, and La, respectively. When expressed as body concentration, the LC50inter value was almost constant with time, demonstrating that internal body concentration could be a better indicator of dynamic toxicity of REEs than external dose. This study highlights that specific REE and exposure time should be taken into account in accurately assessing risk of REEs. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/32126438/Do_toxicokinetic_and_toxicodynamic_processes_hold_the_same_for_light_and_heavy_rare_earth_elements_in_terrestrial_organism_Enchytraeus_crypticus DB - PRIME DP - Unbound Medicine ER -