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Agitation of the syringe and release of silicone oil.
Eye (Lond). 2020 Mar 03 [Online ahead of print]E

Abstract

BACKGROUND/OBJECTIVES

To investigate whether agitation promotes the release of silicone oil by different models of syringe used for intravitreal injection.

METHODS

This lab study analyzed eight syringe models by light microscopy for the release of silicone oil under agitation (flick), without agitation, and positive controls. Fourier-Transform Infrared Spectroscopy (FTIR) was performed to identify the molecular compounds inside the syringes.

RESULTS

A total of 240 syringes were analyzed. The presence of silicone oil droplets was observed in all positive controls. When agitated by flicking, 100% of the samples of the syringes disclosed silicone oil, except the BD Plastipak syringe, which presented 40% of positivity. Without agitation, a smaller percentage of samples with silicone oil was observed. Agitation by flicking had a 265-fold greater chance of presenting oil droplets when compared with the syringes without agitation. There was a statistically significant difference between the three conditions (P < 0.05). Analysis of the tip of the plunger rubber by FTIR indicated the presence of polysiloxane (silicone oil) in all models of syringe.

CONCLUSIONS

Agitation of the syringe promotes the release of silicone oil. It is recommended to improve the technique of injection and the manufacture of specific syringes for ophthalmological use.

Authors+Show Affiliations

Hospital de Olhos de Sergipe, Aracaju-SE, Brazil.Hospital de Olhos de Sergipe, Aracaju-SE, Brazil.Tiradentes University - UNIT, Aracaju-SE, Brazil.Chemical Analysis Laboratory, Center for Chemistry and Manufactured Goods, Institute for Technological Research, São Paulo-SP, Brazil.Hospital de Olhos de Sergipe, Aracaju-SE, Brazil. gustavobmelo@yahoo.com.br. Federal University of São Paulo, São Paulo-SP, Brazil. gustavobmelo@yahoo.com.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32127655

Citation

Dias Júnior, Celso de Souza, et al. "Agitation of the Syringe and Release of Silicone Oil." Eye (London, England), 2020.
Dias Júnior CS, Cardoso AL, Figueiredo AGA, et al. Agitation of the syringe and release of silicone oil. Eye (Lond). 2020.
Dias Júnior, C. S., Cardoso, A. L., Figueiredo, A. G. A., Ota, S., & Melo, G. B. (2020). Agitation of the syringe and release of silicone oil. Eye (London, England). https://doi.org/10.1038/s41433-020-0800-9
Dias Júnior CS, et al. Agitation of the Syringe and Release of Silicone Oil. Eye (Lond). 2020 Mar 3; PubMed PMID: 32127655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Agitation of the syringe and release of silicone oil. AU - Dias Júnior,Celso de Souza, AU - Cardoso,Alexandre Lima, AU - Figueiredo,Ana Galrão de Almeida, AU - Ota,Shoko, AU - Melo,Gustavo Barreto, Y1 - 2020/03/03/ PY - 2019/07/26/received PY - 2019/12/10/accepted PY - 2019/12/03/revised PY - 2020/3/5/entrez JF - Eye (London, England) JO - Eye (Lond) N2 - BACKGROUND/OBJECTIVES: To investigate whether agitation promotes the release of silicone oil by different models of syringe used for intravitreal injection. METHODS: This lab study analyzed eight syringe models by light microscopy for the release of silicone oil under agitation (flick), without agitation, and positive controls. Fourier-Transform Infrared Spectroscopy (FTIR) was performed to identify the molecular compounds inside the syringes. RESULTS: A total of 240 syringes were analyzed. The presence of silicone oil droplets was observed in all positive controls. When agitated by flicking, 100% of the samples of the syringes disclosed silicone oil, except the BD Plastipak syringe, which presented 40% of positivity. Without agitation, a smaller percentage of samples with silicone oil was observed. Agitation by flicking had a 265-fold greater chance of presenting oil droplets when compared with the syringes without agitation. There was a statistically significant difference between the three conditions (P < 0.05). Analysis of the tip of the plunger rubber by FTIR indicated the presence of polysiloxane (silicone oil) in all models of syringe. CONCLUSIONS: Agitation of the syringe promotes the release of silicone oil. It is recommended to improve the technique of injection and the manufacture of specific syringes for ophthalmological use. SN - 1476-5454 UR - https://www.unboundmedicine.com/medline/citation/32127655/Agitation_of_the_syringe_and_release_of_silicone_oil_ L2 - http://dx.doi.org/10.1038/s41433-020-0800-9 DB - PRIME DP - Unbound Medicine ER -
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