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Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults.
Pediatr Pulmonol. 2020 05; 55(5):1169-1174.PP

Abstract

PURPOSE

To discuss the different characteristics of clinical, laboratory, and chest computed tomography (CT) in pediatric patients from adults with 2019 novel coronavirus (COVID-19) infection.

METHODS

The clinical, laboratory, and chest CT features of 20 pediatric inpatients with COVID-19 infection confirmed by pharyngeal swab COVID-19 nucleic acid test were retrospectively analyzed during 23 January and 8 February 2020. The clinical and laboratory information was obtained from inpatient records. All the patients were undergone chest CT in our hospital.

RESULTS

Thirteen pediatric patients (13/20, 65%) had an identified history of close contact with COVID-19 diagnosed family members. Fever (12/20, 60%) and cough (13/20, 65%) were the most common symptoms. For laboratory findings, procalcitonin elevation (16/20, 80%) should be pay attention to, which is not common in adults. Coinfection (8/20, 40%) is common in pediatric patients. A total of 6 patients presented with unilateral pulmonary lesions (6/20, 30%), 10 with bilateral pulmonary lesions (10/20, 50%), and 4 cases showed no abnormality on chest CT (4/20, 20%). Consolidation with surrounding halo sign was observed in 10 patients (10/20, 50%), ground-glass opacities were observed in 12 patients (12/20, 60%), fine mesh shadow was observed in 4 patients (4/20, 20%), and tiny nodules were observed in 3 patients (3/20, 15%).

CONCLUSION

Procalcitonin elevation and consolidation with surrounding halo signs were common in pediatric patients which were different from adults. It is suggested that underlying coinfection may be more common in pediatrics, and the consolidation with surrounding halo sign which is considered as a typical sign in pediatric patients.

Authors+Show Affiliations

Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32134205

Citation

Xia, Wei, et al. "Clinical and CT Features in Pediatric Patients With COVID-19 Infection: Different Points From Adults." Pediatric Pulmonology, vol. 55, no. 5, 2020, pp. 1169-1174.
Xia W, Shao J, Guo Y, et al. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020;55(5):1169-1174.
Xia, W., Shao, J., Guo, Y., Peng, X., Li, Z., & Hu, D. (2020). Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatric Pulmonology, 55(5), 1169-1174. https://doi.org/10.1002/ppul.24718
Xia W, et al. Clinical and CT Features in Pediatric Patients With COVID-19 Infection: Different Points From Adults. Pediatr Pulmonol. 2020;55(5):1169-1174. PubMed PMID: 32134205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. AU - Xia,Wei, AU - Shao,Jianbo, AU - Guo,Yu, AU - Peng,Xuehua, AU - Li,Zhen, AU - Hu,Daoyu, Y1 - 2020/03/05/ PY - 2020/02/14/received PY - 2020/02/26/accepted PY - 2020/3/7/pubmed PY - 2020/4/18/medline PY - 2020/3/6/entrez KW - COVID-19 KW - child KW - clinical features KW - infection KW - tomography SP - 1169 EP - 1174 JF - Pediatric pulmonology JO - Pediatr Pulmonol VL - 55 IS - 5 N2 - PURPOSE: To discuss the different characteristics of clinical, laboratory, and chest computed tomography (CT) in pediatric patients from adults with 2019 novel coronavirus (COVID-19) infection. METHODS: The clinical, laboratory, and chest CT features of 20 pediatric inpatients with COVID-19 infection confirmed by pharyngeal swab COVID-19 nucleic acid test were retrospectively analyzed during 23 January and 8 February 2020. The clinical and laboratory information was obtained from inpatient records. All the patients were undergone chest CT in our hospital. RESULTS: Thirteen pediatric patients (13/20, 65%) had an identified history of close contact with COVID-19 diagnosed family members. Fever (12/20, 60%) and cough (13/20, 65%) were the most common symptoms. For laboratory findings, procalcitonin elevation (16/20, 80%) should be pay attention to, which is not common in adults. Coinfection (8/20, 40%) is common in pediatric patients. A total of 6 patients presented with unilateral pulmonary lesions (6/20, 30%), 10 with bilateral pulmonary lesions (10/20, 50%), and 4 cases showed no abnormality on chest CT (4/20, 20%). Consolidation with surrounding halo sign was observed in 10 patients (10/20, 50%), ground-glass opacities were observed in 12 patients (12/20, 60%), fine mesh shadow was observed in 4 patients (4/20, 20%), and tiny nodules were observed in 3 patients (3/20, 15%). CONCLUSION: Procalcitonin elevation and consolidation with surrounding halo signs were common in pediatric patients which were different from adults. It is suggested that underlying coinfection may be more common in pediatrics, and the consolidation with surrounding halo sign which is considered as a typical sign in pediatric patients. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/32134205/Clinical_and_CT_features_in_pediatric_patients_with_COVID_19_infection:_Different_points_from_adults_ L2 - https://doi.org/10.1002/ppul.24718 DB - PRIME DP - Unbound Medicine ER -