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Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL).
Diabetes Care. 2020 05; 43(5):1111-1117.DC

Abstract

OBJECTIVE

Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos.

RESEARCH DESIGN AND METHODS

The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) is an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability-sampled (i.e., representative of targeted populations), and prospective cohort study. Between 2016 and 2018, SOL-INCA enrolled diverse Hispanics/Latinos aged ≥50 years (n = 6,377). Global cognitive decline and mild cognitive impairment (MCI) were the primary outcomes.

RESULTS

Prevalent diabetes at visit 1, but not incident diabetes at visit 2, was associated with significantly steeper global cognitive decline (βGC = -0.16 [95% CI -0.25; -0.07]; P < 0.001), domain-specific cognitive decline, and higher odds of MCI (odds ratio 1.74 [95% CI 1.34; 2.26]; P < 0.001) compared with no diabetes in age- and sex-adjusted models.

CONCLUSIONS

Diabetes was associated with cognitive decline and increased MCI prevalence among diverse Hispanics/Latinos, primarily among those with prevalent diabetes at visit 1. Our findings suggest that significant cognitive decline and MCI may be considered additional disease complications of diabetes among diverse middle-aged and older Hispanics/Latinos.

Authors+Show Affiliations

Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, San Diego, CA hmg002@health.ucsd.edu.Institute of Gerontology and Department of Healthcare Sciences, Wayne State University, Detroit, MI.Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California, San Diego, San Diego, CA hmg002@health.ucsd.edu.University of Texas Health Science Center, Houston, TX.Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.Department of Psychology, San Diego State University, San Diego, CA.Department of Psychology, San Diego State University, San Diego, CA.Institute for Minority Health Research, College of Medicine, University of Illinois at Chicago, Chicago, IL.Albert Einstein College of Medicine, New York, NY.Albert Einstein College of Medicine, New York, NY. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.Department of Neurology, University of Miami, Miami, FL.Institute for Minority Health Research, College of Medicine, University of Illinois at Chicago, Chicago, IL. Department of Psychiatry and Behavioral Sciences and Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.Department of Neurology and Alzheimer's Disease Center, University of California, Davis, Sacramento, CA.Department of Psychology, University of Miami, Miami, FL.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

32139382

Citation

González, Hector M., et al. "Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL)." Diabetes Care, vol. 43, no. 5, 2020, pp. 1111-1117.
González HM, Tarraf W, González KA, et al. Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL). Diabetes Care. 2020;43(5):1111-1117.
González, H. M., Tarraf, W., González, K. A., Fornage, M., Zeng, D., Gallo, L. C., Talavera, G. A., Daviglus, M. L., Lipton, R. B., Kaplan, R., Ramos, A. R., Lamar, M., Cai, J., DeCarli, C., & Schneiderman, N. (2020). Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL). Diabetes Care, 43(5), 1111-1117. https://doi.org/10.2337/dc19-1676
González HM, et al. Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL). Diabetes Care. 2020;43(5):1111-1117. PubMed PMID: 32139382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL). AU - González,Hector M, AU - Tarraf,Wassim, AU - González,Kevin A, AU - Fornage,Myriam, AU - Zeng,Donglin, AU - Gallo,Linda C, AU - Talavera,Gregory A, AU - Daviglus,Martha L, AU - Lipton,Richard B, AU - Kaplan,Robert, AU - Ramos,Alberto R, AU - Lamar,Melissa, AU - Cai,Jianwen, AU - DeCarli,Charles, AU - Schneiderman,Neil, Y1 - 2020/03/05/ PY - 2019/08/20/received PY - 2020/01/27/accepted PY - 2021/05/01/pmc-release PY - 2020/3/7/pubmed PY - 2021/2/27/medline PY - 2020/3/7/entrez SP - 1111 EP - 1117 JF - Diabetes care JO - Diabetes Care VL - 43 IS - 5 N2 - OBJECTIVE: Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos. RESEARCH DESIGN AND METHODS: The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) is an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability-sampled (i.e., representative of targeted populations), and prospective cohort study. Between 2016 and 2018, SOL-INCA enrolled diverse Hispanics/Latinos aged ≥50 years (n = 6,377). Global cognitive decline and mild cognitive impairment (MCI) were the primary outcomes. RESULTS: Prevalent diabetes at visit 1, but not incident diabetes at visit 2, was associated with significantly steeper global cognitive decline (βGC = -0.16 [95% CI -0.25; -0.07]; P < 0.001), domain-specific cognitive decline, and higher odds of MCI (odds ratio 1.74 [95% CI 1.34; 2.26]; P < 0.001) compared with no diabetes in age- and sex-adjusted models. CONCLUSIONS: Diabetes was associated with cognitive decline and increased MCI prevalence among diverse Hispanics/Latinos, primarily among those with prevalent diabetes at visit 1. Our findings suggest that significant cognitive decline and MCI may be considered additional disease complications of diabetes among diverse middle-aged and older Hispanics/Latinos. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/32139382/Diabetes_Cognitive_Decline_and_Mild_Cognitive_Impairment_Among_Diverse_Hispanics/Latinos:_Study_of_Latinos_Investigation_of_Neurocognitive_Aging_Results__HCHS/SOL__ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=32139382 DB - PRIME DP - Unbound Medicine ER -