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COVID-19 (Novel Coronavirus 2019) - recent trends.
Eur Rev Med Pharmacol Sci. 2020 02; 24(4):2006-2011.ER

Abstract

The World Health Organization (WHO) has issued a warning that, although the 2019 novel coronavirus (COVID-19) from Wuhan City (China), is not pandemic, it should be contained to prevent the global spread. The COVID-19 virus was known earlier as 2019-nCoV. As of 12 February 2020, WHO reported 45,171 cases and 1115 deaths related to COVID-19. COVID-19 is similar to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) virus in its pathogenicity, clinical spectrum, and epidemiology. Comparison of the genome sequences of COVID-19, SARS-CoV, and Middle East Respiratory Syndrome coronavirus (MERS-CoV) showed that COVID-19 has a better sequence identity with SARS-CoV compared to MERS CoV. However, the amino acid sequence of COVID-19 differs from other coronaviruses specifically in the regions of 1ab polyprotein and surface glycoprotein or S-protein. Although several animals have been speculated to be a reservoir for COVID-19, no animal reservoir has been already confirmed. COVID-19 causes COVID-19 disease that has similar symptoms as SARS-CoV. Studies suggest that the human receptor for COVID-19 may be angiotensin-converting enzyme 2 (ACE2) receptor similar to that of SARS-CoV. The nucleocapsid (N) protein of COVID-19 has nearly 90% amino acid sequence identity with SARS-CoV. The N protein antibodies of SARS-CoV may cross react with COVID-19 but may not provide cross-immunity. In a similar fashion to SARS-CoV, the N protein of COVID-19 may play an important role in suppressing the RNA interference (RNAi) to overcome the host defense. This mini-review aims at investigating the most recent trend of COVID-19.

Authors+Show Affiliations

School of Medicine, The Maldives National University, Male', Maldives. Kannan.subbaram@mnu.edu.mv.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32141569

Citation

Kannan, S, et al. "COVID-19 (Novel Coronavirus 2019) - Recent Trends." European Review for Medical and Pharmacological Sciences, vol. 24, no. 4, 2020, pp. 2006-2011.
Kannan S, Shaik Syed Ali P, Sheeza A, et al. COVID-19 (Novel Coronavirus 2019) - recent trends. Eur Rev Med Pharmacol Sci. 2020;24(4):2006-2011.
Kannan, S., Shaik Syed Ali, P., Sheeza, A., & Hemalatha, K. (2020). COVID-19 (Novel Coronavirus 2019) - recent trends. European Review for Medical and Pharmacological Sciences, 24(4), 2006-2011. https://doi.org/10.26355/eurrev_202002_20378
Kannan S, et al. COVID-19 (Novel Coronavirus 2019) - Recent Trends. Eur Rev Med Pharmacol Sci. 2020;24(4):2006-2011. PubMed PMID: 32141569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 (Novel Coronavirus 2019) - recent trends. AU - Kannan,S, AU - Shaik Syed Ali,P, AU - Sheeza,A, AU - Hemalatha,K, PY - 2020/3/7/entrez PY - 2020/3/7/pubmed PY - 2020/3/19/medline SP - 2006 EP - 2011 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 24 IS - 4 N2 - The World Health Organization (WHO) has issued a warning that, although the 2019 novel coronavirus (COVID-19) from Wuhan City (China), is not pandemic, it should be contained to prevent the global spread. The COVID-19 virus was known earlier as 2019-nCoV. As of 12 February 2020, WHO reported 45,171 cases and 1115 deaths related to COVID-19. COVID-19 is similar to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) virus in its pathogenicity, clinical spectrum, and epidemiology. Comparison of the genome sequences of COVID-19, SARS-CoV, and Middle East Respiratory Syndrome coronavirus (MERS-CoV) showed that COVID-19 has a better sequence identity with SARS-CoV compared to MERS CoV. However, the amino acid sequence of COVID-19 differs from other coronaviruses specifically in the regions of 1ab polyprotein and surface glycoprotein or S-protein. Although several animals have been speculated to be a reservoir for COVID-19, no animal reservoir has been already confirmed. COVID-19 causes COVID-19 disease that has similar symptoms as SARS-CoV. Studies suggest that the human receptor for COVID-19 may be angiotensin-converting enzyme 2 (ACE2) receptor similar to that of SARS-CoV. The nucleocapsid (N) protein of COVID-19 has nearly 90% amino acid sequence identity with SARS-CoV. The N protein antibodies of SARS-CoV may cross react with COVID-19 but may not provide cross-immunity. In a similar fashion to SARS-CoV, the N protein of COVID-19 may play an important role in suppressing the RNA interference (RNAi) to overcome the host defense. This mini-review aims at investigating the most recent trend of COVID-19. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/32141569/COVID_19__Novel_Coronavirus_2019____recent_trends_ L2 - https://www.europeanreview.org/article/20378 DB - PRIME DP - Unbound Medicine ER -