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Effect of vedic music on steroidogenic gene expression in 3D-cultured buffalo granulosa cell spheroids model system, a pilot study.
Reprod Domest Anim. 2020 Mar 07 [Online ahead of print]RD

Abstract

Music is known for reducing stress, anxiety and depression, improving cognitive performance, and enhancing estrogen levels. However, its effect on non-auditory mammalian cell system and the molecular events leading to higher estrogen levels is less explored. Therefore, the present study targeted to know the direct effects of peaceful Vedic music on 3D cultured buffalo granulosa cell spheroids. The spheroids were daily exposed to the Mahamrityunjaya mantra, a kind of Vedic chants, for 1.5 h for six days. After six days, the music effect was analysed by the expression analysis of steroidogenic (CYP19A1, STAR and HSD17β1) and proliferative marker (PCNA) genes. Interestingly, the CYP19A1 gene expression was significantly up-regulated by 3.464±0.15 folds in the music exposed spheroids than the non-exposed spheroids. However, the expression of other steroidogenic and proliferative genes were unaltered. These observations provided a transcriptional clue for higher estradiol levels by the music and a scope to use Vedic chants for increasing the CYP19A1 expression to help tackle some pathophysiologcial conditions.

Authors+Show Affiliations

Molecular Endocrinology, Functional Genomics and Systems Biology Lab, Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.Molecular Endocrinology, Functional Genomics and Systems Biology Lab, Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.Molecular Endocrinology, Functional Genomics and Systems Biology Lab, Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.Molecular Endocrinology, Functional Genomics and Systems Biology Lab, Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.Molecular Endocrinology, Functional Genomics and Systems Biology Lab, Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.Molecular Endocrinology, Functional Genomics and Systems Biology Lab, Animal Biochemistry Division, National Dairy Research Institute, Karnal, 132001, Haryana, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32144832

Citation

Pandey, Mamta, et al. "Effect of Vedic Music On Steroidogenic Gene Expression in 3D-cultured Buffalo Granulosa Cell Spheroids Model System, a Pilot Study." Reproduction in Domestic Animals = Zuchthygiene, 2020.
Pandey M, Singh C, Goud ESK, et al. Effect of vedic music on steroidogenic gene expression in 3D-cultured buffalo granulosa cell spheroids model system, a pilot study. Reprod Domest Anim. 2020.
Pandey, M., Singh, C., Goud, E. S. K., Veerappa, V. G., Singh, D., & Onteru, S. K. (2020). Effect of vedic music on steroidogenic gene expression in 3D-cultured buffalo granulosa cell spheroids model system, a pilot study. Reproduction in Domestic Animals = Zuchthygiene. https://doi.org/10.1111/rda.13671
Pandey M, et al. Effect of Vedic Music On Steroidogenic Gene Expression in 3D-cultured Buffalo Granulosa Cell Spheroids Model System, a Pilot Study. Reprod Domest Anim. 2020 Mar 7; PubMed PMID: 32144832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vedic music on steroidogenic gene expression in 3D-cultured buffalo granulosa cell spheroids model system, a pilot study. AU - Pandey,Mamta, AU - Singh,Chhama, AU - Goud,Emmagouni Sharath K, AU - Veerappa,Vedamurthy G, AU - Singh,Dheer, AU - Onteru,Suneel Kumar, Y1 - 2020/03/07/ PY - 2020/3/8/entrez KW - CYP19A1 KW - HSD17β1 KW - PCNA KW - STAR KW - Buffalo granulosa cells spheroids KW - Vedic chants JF - Reproduction in domestic animals = Zuchthygiene JO - Reprod. Domest. Anim. N2 - Music is known for reducing stress, anxiety and depression, improving cognitive performance, and enhancing estrogen levels. However, its effect on non-auditory mammalian cell system and the molecular events leading to higher estrogen levels is less explored. Therefore, the present study targeted to know the direct effects of peaceful Vedic music on 3D cultured buffalo granulosa cell spheroids. The spheroids were daily exposed to the Mahamrityunjaya mantra, a kind of Vedic chants, for 1.5 h for six days. After six days, the music effect was analysed by the expression analysis of steroidogenic (CYP19A1, STAR and HSD17β1) and proliferative marker (PCNA) genes. Interestingly, the CYP19A1 gene expression was significantly up-regulated by 3.464±0.15 folds in the music exposed spheroids than the non-exposed spheroids. However, the expression of other steroidogenic and proliferative genes were unaltered. These observations provided a transcriptional clue for higher estradiol levels by the music and a scope to use Vedic chants for increasing the CYP19A1 expression to help tackle some pathophysiologcial conditions. SN - 1439-0531 UR - https://www.unboundmedicine.com/medline/citation/32144832/Effect_of_vedic_music_on_steroidogenic_gene_expression_in_3D-cultured_buffalo_granulosa_cell_spheroids_model_system,_a_pilot_study L2 - https://doi.org/10.1111/rda.13671 DB - PRIME DP - Unbound Medicine ER -
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