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Quantification of North American and European Crataegus flavonoids by nuclear magnetic resonance spectrometry.
Fitoterapia. 2020 Jun; 143:104537.F

Abstract

Crataegus (Rosaceae; hawthorn), are small trees that grow in the Northern Hemisphere. Plant materials of Crataegus show promising benefits in adjunctive treatment of cardiovascular disorders, primarily attributed to flavonoids and other phenolic derivatives. 1H NMR was used in quantification of four flavonoids (naringenin, hyperoside, rutin, and vitexin-2″-O-rhamnoside) and chlorogenic acid in leaf extracts of four Crataegus species. The data were validated by comparison to HPLC-DAD. Vitexin and its derivatives were significantly more concentrated in the European (C. monogyna and C. laevigata) leaves and rutin significantly more concentrated in the North American (C. douglasii and C. okanaganensis) leaves. The concentrations of rutin and naringenin reported in this study are the highest reported for Crataegus. This work represents the first quantitative report of flavonoids in the North American hawthorns C. douglasii and C. okanaganensis and a direct comparison with the common European species.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lund JA
Chemistry, The University of British Columbia, Okanagan Campus, 3333 University Way, Kelowna, British Columbia V1V 1V7, Canada.
Brown PN
Natural Health & Food Products Research, British Columbia Institute of Technology, 3700 Willingdon Ave, Burnaby, British Columbia V5G 3H2, Canada.
Shipley PR
Chemistry, The University of British Columbia, Okanagan Campus, 3333 University Way, Kelowna, British Columbia V1V 1V7, Canada. Electronic address: paul.shipley@ubc.ca.

MeSH

Chromatography, High Pressure LiquidCrataegusEuropeFlavanonesFlavonoidsGlycosidesMagnetic Resonance SpectroscopyMolecular StructureNorth AmericaPhytochemicalsPlant LeavesQuercetinRutin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32145312

Citation

Lund, Jensen A., et al. "Quantification of North American and European Crataegus Flavonoids By Nuclear Magnetic Resonance Spectrometry." Fitoterapia, vol. 143, 2020, p. 104537.
Lund JA, Brown PN, Shipley PR. Quantification of North American and European Crataegus flavonoids by nuclear magnetic resonance spectrometry. Fitoterapia. 2020;143:104537.
Lund, J. A., Brown, P. N., & Shipley, P. R. (2020). Quantification of North American and European Crataegus flavonoids by nuclear magnetic resonance spectrometry. Fitoterapia, 143, 104537. https://doi.org/10.1016/j.fitote.2020.104537
Lund JA, Brown PN, Shipley PR. Quantification of North American and European Crataegus Flavonoids By Nuclear Magnetic Resonance Spectrometry. Fitoterapia. 2020;143:104537. PubMed PMID: 32145312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of North American and European Crataegus flavonoids by nuclear magnetic resonance spectrometry. AU - Lund,Jensen A, AU - Brown,Paula N, AU - Shipley,Paul R, Y1 - 2020/03/04/ PY - 2019/10/03/received PY - 2020/02/28/revised PY - 2020/03/01/accepted PY - 2020/3/8/pubmed PY - 2021/1/28/medline PY - 2020/3/8/entrez KW - Crataegus KW - Flavonoids KW - Hawthorn KW - NMR KW - Nuclear magnetic resonance KW - Rosaceae KW - qNMR SP - 104537 EP - 104537 JF - Fitoterapia JO - Fitoterapia VL - 143 N2 - Crataegus (Rosaceae; hawthorn), are small trees that grow in the Northern Hemisphere. Plant materials of Crataegus show promising benefits in adjunctive treatment of cardiovascular disorders, primarily attributed to flavonoids and other phenolic derivatives. 1H NMR was used in quantification of four flavonoids (naringenin, hyperoside, rutin, and vitexin-2″-O-rhamnoside) and chlorogenic acid in leaf extracts of four Crataegus species. The data were validated by comparison to HPLC-DAD. Vitexin and its derivatives were significantly more concentrated in the European (C. monogyna and C. laevigata) leaves and rutin significantly more concentrated in the North American (C. douglasii and C. okanaganensis) leaves. The concentrations of rutin and naringenin reported in this study are the highest reported for Crataegus. This work represents the first quantitative report of flavonoids in the North American hawthorns C. douglasii and C. okanaganensis and a direct comparison with the common European species. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/32145312/Quantification_of_North_American_and_European_Crataegus_flavonoids_by_nuclear_magnetic_resonance_spectrometry_ DB - PRIME DP - Unbound Medicine ER -