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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.
Emerg Infect Dis. 2020 May; 26(5):1024-1027.EI

Abstract

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

32150528

Citation

Okba, Nisreen M A., et al. "Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies." Emerging Infectious Diseases, vol. 26, no. 5, 2020, pp. 1024-1027.
Okba NMA, Widjaja I, Li W, et al. Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies. Emerg Infect Dis. 2020;26(5):1024-1027.
Okba, N. M. A., Widjaja, I., Li, W., GeurtsvanKessel, C. H., Farag, E. A. B. A., Al-Hajri, M., Park, W. B., Oh, M. D., Reusken, C. B. E. M., Koopmans, M. P. G., Bosch, B. J., & Haagmans, B. L. (2020). Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies. Emerging Infectious Diseases, 26(5), 1024-1027. https://doi.org/10.3201/eid2605.190921
Okba NMA, et al. Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies. Emerg Infect Dis. 2020;26(5):1024-1027. PubMed PMID: 32150528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies. AU - Okba,Nisreen M A, AU - Widjaja,Ivy, AU - Li,Wentao, AU - GeurtsvanKessel,Corine H, AU - Farag,Elmoubasher A B A, AU - Al-Hajri,Mohammed, AU - Park,Wan Beom, AU - Oh,Myoung-Don, AU - Reusken,Chantal B E M, AU - Koopmans,Marion P G, AU - Bosch,Berend-Jan, AU - Haagmans,Bart L, Y1 - 2020/05/17/ PY - 2020/3/10/pubmed PY - 2020/9/18/medline PY - 2020/3/10/entrez KW - MERS KW - MERS-CoV KW - Middle East respiratory syndrome KW - Middle East respiratory syndrome coronavirus KW - antibodies KW - dromedary KW - hemagglutination KW - human KW - lumazine synthase KW - nanoparticle KW - neutralization KW - respiratory infections KW - serology KW - spike KW - viruses KW - zoonoses SP - 1024 EP - 1027 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 26 IS - 5 N2 - We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/32150528/Serologic_Detection_of_Middle_East_Respiratory_Syndrome_Coronavirus_Functional_Antibodies_ L2 - https://doi.org/10.3201/eid2605.190921 DB - PRIME DP - Unbound Medicine ER -