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C-Type Lectin Receptors in Antifungal Immunity.
Adv Exp Med Biol. 2020; 1204:1-30.AE

Abstract

Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall contains conserved pathogen-associated molecular patterns (PAMPs), which allow the immune system to distinguish between self (endogenous molecular patterns) and foreign material. Sensing of invasive microbial pathogens is achieved through recognition of PAMPs by pattern recognition receptors (PRRs). One of the predominant fungal-sensing PRRs is the C-type lectin receptor (CLR) family. These receptors bind to structures present on the fungal cell wall, eliciting various innate immune responses as well as shaping adaptive immunity. In this chapter, we specifically focus on the four major human fungal pathogens, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans and Pneumocystis jirovecii, reviewing our current understanding of the CLRs that are involved in their recognition and protection of the host.

Authors+Show Affiliations

Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, EX4 4QD, UK. Previous address: MRC Centre for Medical Mycology, University of Aberdeen, Aberdeen, AB25 2ZD, UK.Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, EX4 4QD, UK. Previous address: MRC Centre for Medical Mycology, University of Aberdeen, Aberdeen, AB25 2ZD, UK.Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, EX4 4QD, UK. Gordon.Brown@exeter.ac.uk. Previous address: MRC Centre for Medical Mycology, University of Aberdeen, Aberdeen, AB25 2ZD, UK. Gordon.Brown@exeter.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32152941

Citation

Nikolakopoulou, Christina, et al. "C-Type Lectin Receptors in Antifungal Immunity." Advances in Experimental Medicine and Biology, vol. 1204, 2020, pp. 1-30.
Nikolakopoulou C, Willment JA, Brown GD. C-Type Lectin Receptors in Antifungal Immunity. Adv Exp Med Biol. 2020;1204:1-30.
Nikolakopoulou, C., Willment, J. A., & Brown, G. D. (2020). C-Type Lectin Receptors in Antifungal Immunity. Advances in Experimental Medicine and Biology, 1204, 1-30. https://doi.org/10.1007/978-981-15-1580-4_1
Nikolakopoulou C, Willment JA, Brown GD. C-Type Lectin Receptors in Antifungal Immunity. Adv Exp Med Biol. 2020;1204:1-30. PubMed PMID: 32152941.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-Type Lectin Receptors in Antifungal Immunity. AU - Nikolakopoulou,Christina, AU - Willment,Janet A, AU - Brown,Gordon D, PY - 2020/3/11/entrez PY - 2020/3/11/pubmed PY - 2020/3/26/medline KW - Antifungal immunity KW - CLRs KW - PRRs KW - Pathogenic fungi SP - 1 EP - 30 JF - Advances in experimental medicine and biology JO - Adv. Exp. Med. Biol. VL - 1204 N2 - Most fungal species are harmless to humans and some exist as commensals on mucocutaneous surfaces. Yet many fungi are opportunistic pathogens, causing life-threatening invasive infections when the immune system becomes compromised. The fungal cell wall contains conserved pathogen-associated molecular patterns (PAMPs), which allow the immune system to distinguish between self (endogenous molecular patterns) and foreign material. Sensing of invasive microbial pathogens is achieved through recognition of PAMPs by pattern recognition receptors (PRRs). One of the predominant fungal-sensing PRRs is the C-type lectin receptor (CLR) family. These receptors bind to structures present on the fungal cell wall, eliciting various innate immune responses as well as shaping adaptive immunity. In this chapter, we specifically focus on the four major human fungal pathogens, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans and Pneumocystis jirovecii, reviewing our current understanding of the CLRs that are involved in their recognition and protection of the host. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/32152941/C_Type_Lectin_Receptors_in_Antifungal_Immunity_ L2 - https://dx.doi.org/10.1007/978-981-15-1580-4_1 DB - PRIME DP - Unbound Medicine ER -