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Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia.
Transl Pediatr. 2020 Feb; 9(1):51-60.TP

Abstract

Background

The newly identified 2019-nCoV, which appears to have originated in Wuhan, the capital city of Hubei province in central China, is spreading rapidly nationwide. A number of cases of neonates born to mothers with 2019-nCoV pneumonia have been recorded. However, the clinical features of these cases have not been reported, and there is no sufficient evidence for the proper prevention and control of 2019-nCoV infections in neonates.

Methods

The clinical features and outcomes of 10 neonates (including 2 twins) born to 9 mothers with confirmed 2019-nCoV infection in 5 hospitals from January 20 to February 5, 2020 were retrospectively analyzed.

Results

Among these 9 pregnant women with confirmed 2019-nCoV infection, onset of clinical symptoms occurred before delivery in 4 cases, on the day of delivery in 2 cases, and after delivery in 3 cases. In most cases, fever and a cough were the first symptoms experienced, and 1 patient also had diarrhea. Of the newborns born to these mothers, 8 were male and 2 were female; 4 were full-term infants and 6 were born premature; 2 were small-for-gestational-age (SGA) infants and 1 was a large-for-gestational-age (LGA) infant; there were 8 singletons and 2 twins. Of the neonates, 6 had a Pediatric Critical Illness Score (PCIS) score of less than 90. Clinically, the first symptom in the neonates was shortness of breath (n=6), but other initial symptoms such as fever (n=2), thrombocytopenia accompanied by abnormal liver function (n=2), rapid heart rate (n=1), vomiting (n=1), and pneumothorax (n=1) were observed. Up to now, 5 neonates have been cured and discharged, 1 has died, and 4 neonates remain in hospital in a stable condition. Pharyngeal swab specimens were collected from 9 of the 10 neonates 1 to 9 days after birth for nucleic acid amplification tests for 2019-nCoV, all of which showed negative results.

Conclusions

Perinatal 2019-nCoV infection may have adverse effects on newborns, causing problems such as fetal distress, premature labor, respiratory distress, thrombocytopenia accompanied by abnormal liver function, and even death. However, vertical transmission of 2019-nCoV is yet to be confirmed.

Authors+Show Affiliations

Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Wuhan 430070, China.Department of Neonatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan 430060, China.Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Wuhan 430070, China.Department of Neonatology, Tianmen First People's Hospital, Tianmen 431700, China.Department of Pediatrics, Jingzhou Municipal Maternal and Child Health Hospital, Jingzhou 434020, China.Department of Neonatology, Maternal and Child Health Hospital of Hubei Province, Wuhan 430070, China.Department of Neonatology, Pediatric Hospital Affiliated to Fudan University, Shanghai 200032, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32154135

Citation

Zhu, Huaping, et al. "Clinical Analysis of 10 Neonates Born to Mothers With 2019-nCoV Pneumonia." Translational Pediatrics, vol. 9, no. 1, 2020, pp. 51-60.
Zhu H, Wang L, Fang C, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51-60.
Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., Xia, S., & Zhou, W. (2020). Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational Pediatrics, 9(1), 51-60. https://doi.org/10.21037/tp.2020.02.06
Zhu H, et al. Clinical Analysis of 10 Neonates Born to Mothers With 2019-nCoV Pneumonia. Transl Pediatr. 2020;9(1):51-60. PubMed PMID: 32154135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. AU - Zhu,Huaping, AU - Wang,Lin, AU - Fang,Chengzhi, AU - Peng,Sicong, AU - Zhang,Lianhong, AU - Chang,Guiping, AU - Xia,Shiwen, AU - Zhou,Wenhao, PY - 2020/3/11/entrez PY - 2020/3/11/pubmed PY - 2020/3/11/medline KW - 2019-nCoV KW - clinical analysis KW - neonates KW - vertical transmission SP - 51 EP - 60 JF - Translational pediatrics JO - Transl Pediatr VL - 9 IS - 1 N2 - Background: The newly identified 2019-nCoV, which appears to have originated in Wuhan, the capital city of Hubei province in central China, is spreading rapidly nationwide. A number of cases of neonates born to mothers with 2019-nCoV pneumonia have been recorded. However, the clinical features of these cases have not been reported, and there is no sufficient evidence for the proper prevention and control of 2019-nCoV infections in neonates. Methods: The clinical features and outcomes of 10 neonates (including 2 twins) born to 9 mothers with confirmed 2019-nCoV infection in 5 hospitals from January 20 to February 5, 2020 were retrospectively analyzed. Results: Among these 9 pregnant women with confirmed 2019-nCoV infection, onset of clinical symptoms occurred before delivery in 4 cases, on the day of delivery in 2 cases, and after delivery in 3 cases. In most cases, fever and a cough were the first symptoms experienced, and 1 patient also had diarrhea. Of the newborns born to these mothers, 8 were male and 2 were female; 4 were full-term infants and 6 were born premature; 2 were small-for-gestational-age (SGA) infants and 1 was a large-for-gestational-age (LGA) infant; there were 8 singletons and 2 twins. Of the neonates, 6 had a Pediatric Critical Illness Score (PCIS) score of less than 90. Clinically, the first symptom in the neonates was shortness of breath (n=6), but other initial symptoms such as fever (n=2), thrombocytopenia accompanied by abnormal liver function (n=2), rapid heart rate (n=1), vomiting (n=1), and pneumothorax (n=1) were observed. Up to now, 5 neonates have been cured and discharged, 1 has died, and 4 neonates remain in hospital in a stable condition. Pharyngeal swab specimens were collected from 9 of the 10 neonates 1 to 9 days after birth for nucleic acid amplification tests for 2019-nCoV, all of which showed negative results. Conclusions: Perinatal 2019-nCoV infection may have adverse effects on newborns, causing problems such as fetal distress, premature labor, respiratory distress, thrombocytopenia accompanied by abnormal liver function, and even death. However, vertical transmission of 2019-nCoV is yet to be confirmed. SN - 2224-4344 UR - https://www.unboundmedicine.com/medline/citation/32154135/full_citation L2 - https://doi.org/10.21037/tp.2020.02.06 DB - PRIME DP - Unbound Medicine ER -
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