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Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT.
Radiology. 2020 Mar 10 [Online ahead of print]R

Abstract

Background Despite its high sensitivity in diagnosing COVID-19 in a screening population, chest CT appearances of COVID 19 pneumonia are thought to be non-specific. Purpose To assess the performance of United States (U.S.) and Chinese radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Methods A total of 219 patients with both positive COVID-19 by RT-PCR and abnormal chest CT findings were retrospectively identified from 7 Chinese hospitals in Hunan Providence, China from January 6 to February 20, 2020. A total of 205 patients with positive Respiratory Pathogen Panel for viral pneumonia and CT findings consistent with or highly suspicious for pneumonia by original radiology interpretation within 7 days of each other were identified from Rhode Island Hospital in Providence, RI. Three Chinese radiologists blindly reviewed all chest CTs (n=424) to differentiate COVID-19 from viral pneumonia. A sample of 58 age-matched cases was randomly selected and evaluated by 4 U.S. radiologists in a similar fashion. Different CT features were recorded and compared between the two groups. Results For all chest CTs, three Chinese radiologists correctly differentiated COVID-19 from non-COVID-19 pneumonia 83% (350/424), 80% (338/424), and 60% (255/424) of the time, respectively. The seven radiologists had sensitivities of 80%, 67%, 97%, 93%, 83%, 73% and 70% and specificities of 100%, 93%, 7%, 100%, 93%, 93%, 100%. Compared to non-COVID-19 pneumonia, COVID-19 pneumonia was more likely to have a peripheral distribution (80% vs. 57%, p<0.001), ground-glass opacity (91% vs. 68%, p<0.001), fine reticular opacity (56% vs. 22%, p<0.001), and vascular thickening (59% vs. 22%, p<0.001), but less likely to have a central+peripheral distribution (14.% vs. 35%, p<0.001), pleural effusion (4.1 vs. 39%, p<0.001) and lymphadenopathy (2.7% vs. 10.2%, p<0.001). Conclusion Radiologists in China and the United States distinguished COVID-19 from viral pneumonia on chest CT with high specificity but moderate sensitivity. A translation of this abstract in Farsi is available in the supplement. - ترجمه چکیده این مقاله به فارسی، در ضمیمه موجود است.

Authors+Show Affiliations

From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).From the Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, China 410008 (Z.X., D.C.W., F.X., S.L., W.H.L.), Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA, 02903 (H.X.B., B.H., K.H., I.P., T.K.E., S.A., T.H., M.K.A.), Brown University Warren Alpert Medical School, Providence, RI, USA 02903 (K.H., J.W.C., T.M.L.T., I.P., T.K.E.), Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA 02912 (L.B.S.), Department of Radiology, Changde Second People's Hospital, Changde, Hunan, China 415001 (J.M.), Department of Radiology, Affiliated Nan Hua Hospital, University of South China, Hengyang, Hunan, China 421002 (X.L.J.), Department of Radiology, Loudi Central Hospital, Loudi, Hunan, China 417000 (Q.H.Z.,), and Department of Radiology, Chenzhou Second People's Hospital, Chenzhou, Hunan, China 423000 (P.F.H.).

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32155105

Citation

Bai, Harrison X., et al. "Performance of Radiologists in Differentiating COVID-19 From Viral Pneumonia On Chest CT." Radiology, 2020, p. 200823.
Bai HX, Hsieh B, Xiong Z, et al. Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Radiology. 2020.
Bai, H. X., Hsieh, B., Xiong, Z., Halsey, K., Choi, J. W., Tran, T. M. L., Pan, I., Shi, L. B., Wang, D. C., Mei, J., Jiang, X. L., Zeng, Q. H., Egglin, T. K., Hu, P. F., Agarwal, S., Xie, F., Li, S., Healey, T., Atalay, M. K., & Liao, W. H. (2020). Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Radiology, 200823. https://doi.org/10.1148/radiol.2020200823
Bai HX, et al. Performance of Radiologists in Differentiating COVID-19 From Viral Pneumonia On Chest CT. Radiology. 2020 Mar 10;200823. PubMed PMID: 32155105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT. AU - Bai,Harrison X, AU - Hsieh,Ben, AU - Xiong,Zeng, AU - Halsey,Kasey, AU - Choi,Ji Whae, AU - Tran,Thi My Linh, AU - Pan,Ian, AU - Shi,Lin-Bo, AU - Wang,Dong-Cui, AU - Mei,Ji, AU - Jiang,Xiao-Long, AU - Zeng,Qiu-Hua, AU - Egglin,Thomas K, AU - Hu,Ping-Feng, AU - Agarwal,Saurabh, AU - Xie,Fangfang, AU - Li,Sha, AU - Healey,Terrance, AU - Atalay,Michael K, AU - Liao,Wei-Hua, Y1 - 2020/03/10/ PY - 2020/3/11/entrez PY - 2020/3/11/pubmed PY - 2020/3/11/medline SP - 200823 EP - 200823 JF - Radiology JO - Radiology N2 - Background Despite its high sensitivity in diagnosing COVID-19 in a screening population, chest CT appearances of COVID 19 pneumonia are thought to be non-specific. Purpose To assess the performance of United States (U.S.) and Chinese radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Methods A total of 219 patients with both positive COVID-19 by RT-PCR and abnormal chest CT findings were retrospectively identified from 7 Chinese hospitals in Hunan Providence, China from January 6 to February 20, 2020. A total of 205 patients with positive Respiratory Pathogen Panel for viral pneumonia and CT findings consistent with or highly suspicious for pneumonia by original radiology interpretation within 7 days of each other were identified from Rhode Island Hospital in Providence, RI. Three Chinese radiologists blindly reviewed all chest CTs (n=424) to differentiate COVID-19 from viral pneumonia. A sample of 58 age-matched cases was randomly selected and evaluated by 4 U.S. radiologists in a similar fashion. Different CT features were recorded and compared between the two groups. Results For all chest CTs, three Chinese radiologists correctly differentiated COVID-19 from non-COVID-19 pneumonia 83% (350/424), 80% (338/424), and 60% (255/424) of the time, respectively. The seven radiologists had sensitivities of 80%, 67%, 97%, 93%, 83%, 73% and 70% and specificities of 100%, 93%, 7%, 100%, 93%, 93%, 100%. Compared to non-COVID-19 pneumonia, COVID-19 pneumonia was more likely to have a peripheral distribution (80% vs. 57%, p<0.001), ground-glass opacity (91% vs. 68%, p<0.001), fine reticular opacity (56% vs. 22%, p<0.001), and vascular thickening (59% vs. 22%, p<0.001), but less likely to have a central+peripheral distribution (14.% vs. 35%, p<0.001), pleural effusion (4.1 vs. 39%, p<0.001) and lymphadenopathy (2.7% vs. 10.2%, p<0.001). Conclusion Radiologists in China and the United States distinguished COVID-19 from viral pneumonia on chest CT with high specificity but moderate sensitivity. A translation of this abstract in Farsi is available in the supplement. - ترجمه چکیده این مقاله به فارسی، در ضمیمه موجود است. SN - 1527-1315 UR - https://www.unboundmedicine.com/medline/citation/32155105/full_citation L2 - http://pubs.rsna.org/doi/10.1148/radiol.2020200823?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
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