Tags

Type your tag names separated by a space and hit enter

A Suboptimal Diet is Associated with Poorer Cognition: The NUDAD Project.
Nutrients. 2020 Mar 06; 12(3)N

Abstract

Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer's disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer's disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition-this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia.

Links

PMC Free PDF

Authors+Show Affiliations

Fieldhouse JLP
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.
Doorduijn AS
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands. Department of Nutrition and Dietetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Public Health Research Institute Amsterdam, 1081HV Amsterdam, The Netherlands.
de Leeuw FA
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.
Verhaar BJH
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.
Koene T
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.
Wesselman LMP
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.
Schueren MV
Department of Nutrition and Dietetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Public Health Research Institute Amsterdam, 1081HV Amsterdam, The Netherlands. Department of Nutrition and Health, HAN University of Applied Sciences, 6525EJ Nijmegen, The Netherlands.
Visser M
Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam and the Amsterdam Public Health Research Institute, 1081HV Amsterdam, The Netherlands.
Rest OV
Division of Human Nutrition and Health, Wageningen University & Research, 6708WE Wageningen, The Netherlands.
Scheltens P
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.
Kester MI
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands.
Flier WMV
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HZ Amsterdam, The Netherlands. Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081HV Amsterdam, The Netherlands.

MeSH

Alcohol DrinkingAlzheimer DiseaseCognitionCognitive DysfunctionDiet, HealthyDietary FatsEatingElder Nutritional Physiological PhenomenaExecutive FunctionFeeding BehaviorFemaleHumansMaleMalnutritionPatient ComplianceRecommended Dietary AllowancesRisk FactorsTrans Fatty AcidsVegetables

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32155876

Citation

Fieldhouse, Jay L P., et al. "A Suboptimal Diet Is Associated With Poorer Cognition: the NUDAD Project." Nutrients, vol. 12, no. 3, 2020.
Fieldhouse JLP, Doorduijn AS, de Leeuw FA, et al. A Suboptimal Diet is Associated with Poorer Cognition: The NUDAD Project. Nutrients. 2020;12(3).
Fieldhouse, J. L. P., Doorduijn, A. S., de Leeuw, F. A., Verhaar, B. J. H., Koene, T., Wesselman, L. M. P., Schueren, M. V., Visser, M., Rest, O. V., Scheltens, P., Kester, M. I., & Flier, W. M. V. (2020). A Suboptimal Diet is Associated with Poorer Cognition: The NUDAD Project. Nutrients, 12(3). https://doi.org/10.3390/nu12030703
Fieldhouse JLP, et al. A Suboptimal Diet Is Associated With Poorer Cognition: the NUDAD Project. Nutrients. 2020 Mar 6;12(3) PubMed PMID: 32155876.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Suboptimal Diet is Associated with Poorer Cognition: The NUDAD Project. AU - Fieldhouse,Jay L P, AU - Doorduijn,Astrid S, AU - de Leeuw,Francisca A, AU - Verhaar,Barbara J H, AU - Koene,Ted, AU - Wesselman,Linda M P, AU - Schueren,Marian de van der, AU - Visser,Marjolein, AU - Rest,Ondine van de, AU - Scheltens,Philip, AU - Kester,Maartje I, AU - Flier,Wiesje M van der, Y1 - 2020/03/06/ PY - 2020/02/07/received PY - 2020/02/27/revised PY - 2020/03/02/accepted PY - 2020/3/12/entrez PY - 2020/3/12/pubmed PY - 2020/12/22/medline KW - dementia KW - food intake KW - mild cognitive impairment KW - neuropsychological functioning KW - nutrition JF - Nutrients JO - Nutrients VL - 12 IS - 3 N2 - Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer's disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer's disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition-this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32155876/A_Suboptimal_Diet_is_Associated_with_Poorer_Cognition:_The_NUDAD_Project_ DB - PRIME DP - Unbound Medicine ER -