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COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.
J Med Virol. 2020 06; 92(6):577-583.JM

Abstract

The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]).

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ncbi.nlm.nih.gov
doi.org
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Authors+Show Affiliations

Li LQ
The First Clinical Medical School, Lanzhou University, Lanzhou, China. Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Huang T
The First Clinical Medical School, Lanzhou University, Lanzhou, China. Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Wang YQ
Day Diagnostic Center, Gansu Provincial Hospital, Lanzhou, China.
Wang ZP
Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
Liang Y
The First Clinical Medical School, Lanzhou University, Lanzhou, China. Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Huang TB
The First Clinical Medical School, Lanzhou University, Lanzhou, China. Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Zhang HY
The First Clinical Medical School, Lanzhou University, Lanzhou, China. Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Sun W
Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China.
Wang Y
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, China. Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.

MeSH

BetacoronavirusBiomarkersC-Reactive ProteinCOVID-19ChinaCoronavirus InfectionsCoughDyspneaFemaleFeverHumansIncidenceLymphopeniaMalePandemicsPatient DischargePneumonia, ViralSARS-CoV-2Sex FactorsSurvival Analysis

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32162702

Clinical Trial Links

FOUND - Ancillary Study to Smile Protocol NCT03654105
Hydrogen-oxygen Gas Mixture Inhalation in Patients With Convalescent Coronavirus Disease 2019 (COVID-19)

Citation

Li, Long-Quan, et al. "COVID-19 Patients' Clinical Characteristics, Discharge Rate, and Fatality Rate of Meta-analysis." Journal of Medical Virology, vol. 92, no. 6, 2020, pp. 577-583.
Li LQ, Huang T, Wang YQ, et al. COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol. 2020;92(6):577-583.
Li, L. Q., Huang, T., Wang, Y. Q., Wang, Z. P., Liang, Y., Huang, T. B., Zhang, H. Y., Sun, W., & Wang, Y. (2020). COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. Journal of Medical Virology, 92(6), 577-583. https://doi.org/10.1002/jmv.25757
Li LQ, et al. COVID-19 Patients' Clinical Characteristics, Discharge Rate, and Fatality Rate of Meta-analysis. J Med Virol. 2020;92(6):577-583. PubMed PMID: 32162702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis. AU - Li,Long-Quan, AU - Huang,Tian, AU - Wang,Yong-Qing, AU - Wang,Zheng-Ping, AU - Liang,Yuan, AU - Huang,Tao-Bi, AU - Zhang,Hui-Yun, AU - Sun,Weiming, AU - Wang,Yuping, Y1 - 2020/03/23/ PY - 2020/03/02/received PY - 2020/03/09/accepted PY - 2020/3/13/pubmed PY - 2020/7/1/medline PY - 2020/3/13/entrez KW - 2019-nCoV KW - COVID-19 KW - clinical characteristics KW - discharge rate KW - fatality rate KW - meta-analysis SP - 577 EP - 583 JF - Journal of medical virology JO - J Med Virol VL - 92 IS - 6 N2 - The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]). SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/32162702/full_citation L2 - https://doi.org/10.1002/jmv.25757 DB - PRIME DP - Unbound Medicine ER -