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Anti-fibrotic activity of gold and platinum complexes - Au(I) compounds as a new class of anti-fibrotic agents.
J Inorg Biochem. 2020 May; 206:111023.JI

Abstract

Molecular gold(I) and platinum(II) species were examined for the inhibition of liver fibrosis and the hepatitis C virus (HCV). Determination of inhibition efficiency was conducted via morphological analysis, cell viability, western blot analysis, and quantitative reverse transcription polymerase chain reaction (RT-PCR). Auranofin and Ph3PAuCl demonstrated the greatest inhibition of liver fibrosis amongst the tested gold species in human hepatic stellate LX-2 cells. Western blot analysis indicated that auranofin and Ph3PAuCl prevent signal transducer and activator of transcription 3 (STAT3) phosphorylation, which may be a key connection to fibrosis and inflammation. Auranofin and Ph3PAuCl also reduced expression of HCV-nonstructural protein 3 (NS3) and HCV-NS5a proteins in a HCV subgenomic replicon system. These results demonstrate significant promise for the use of gold compounds in treating liver diseases such as HCV.

Authors+Show Affiliations

Department of Microbiology and Immunology, Center for Cancer Cell Biology, Immunology and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.Department of Microbiology and Immunology, Center for Cancer Cell Biology, Immunology and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.Department of Chemistry and Biochemistry, College of Science and Health, DePaul University, Chicago, IL 60614, USA.Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.Department of Microbiology and Immunology, Center for Cancer Cell Biology, Immunology and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA.Department of Chemistry and Biochemistry, College of Science and Health, DePaul University, Chicago, IL 60614, USA. Electronic address: kgrice1@depaul.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32163811

Citation

Stratton, Matthew, et al. "Anti-fibrotic Activity of Gold and Platinum Complexes - Au(I) Compounds as a New Class of Anti-fibrotic Agents." Journal of Inorganic Biochemistry, vol. 206, 2020, p. 111023.
Stratton M, Ramachandran A, Camacho EJM, et al. Anti-fibrotic activity of gold and platinum complexes - Au(I) compounds as a new class of anti-fibrotic agents. J Inorg Biochem. 2020;206:111023.
Stratton, M., Ramachandran, A., Camacho, E. J. M., Patil, S., Waris, G., & Grice, K. A. (2020). Anti-fibrotic activity of gold and platinum complexes - Au(I) compounds as a new class of anti-fibrotic agents. Journal of Inorganic Biochemistry, 206, 111023. https://doi.org/10.1016/j.jinorgbio.2020.111023
Stratton M, et al. Anti-fibrotic Activity of Gold and Platinum Complexes - Au(I) Compounds as a New Class of Anti-fibrotic Agents. J Inorg Biochem. 2020;206:111023. PubMed PMID: 32163811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-fibrotic activity of gold and platinum complexes - Au(I) compounds as a new class of anti-fibrotic agents. AU - Stratton,Matthew, AU - Ramachandran,Akshaya, AU - Camacho,Ehxciquiel Jaeroume M, AU - Patil,Shivaputra, AU - Waris,Gulam, AU - Grice,Kyle A, Y1 - 2020/02/11/ PY - 2019/11/25/received PY - 2020/02/06/revised PY - 2020/02/09/accepted PY - 2020/3/13/pubmed PY - 2020/3/13/medline PY - 2020/3/13/entrez KW - Anti-fibrotic compounds KW - Gold KW - Hepatitis C virus KW - Liver fibrosis KW - Metal-based drugs KW - Platinum SP - 111023 EP - 111023 JF - Journal of inorganic biochemistry JO - J. Inorg. Biochem. VL - 206 N2 - Molecular gold(I) and platinum(II) species were examined for the inhibition of liver fibrosis and the hepatitis C virus (HCV). Determination of inhibition efficiency was conducted via morphological analysis, cell viability, western blot analysis, and quantitative reverse transcription polymerase chain reaction (RT-PCR). Auranofin and Ph3PAuCl demonstrated the greatest inhibition of liver fibrosis amongst the tested gold species in human hepatic stellate LX-2 cells. Western blot analysis indicated that auranofin and Ph3PAuCl prevent signal transducer and activator of transcription 3 (STAT3) phosphorylation, which may be a key connection to fibrosis and inflammation. Auranofin and Ph3PAuCl also reduced expression of HCV-nonstructural protein 3 (NS3) and HCV-NS5a proteins in a HCV subgenomic replicon system. These results demonstrate significant promise for the use of gold compounds in treating liver diseases such as HCV. SN - 1873-3344 UR - https://www.unboundmedicine.com/medline/citation/32163811/Anti-fibrotic_activity_of_gold_and_platinum_complexes_-_Au(I)_compounds_as_a_new_class_of_anti-fibrotic_agents L2 - https://linkinghub.elsevier.com/retrieve/pii/S0162-0134(20)30051-9 DB - PRIME DP - Unbound Medicine ER -
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