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Haplotype diversity and phylogenetic characteristics for Guanzhong Han population from Northwest China via 38 Y-STRs using Yfiler™ Platinum Amplification System.
Mol Genet Genomic Med. 2020 05; 8(5):e1187.MG

Abstract

BACKGROUND

For better application in human forensic cases and population genetics research, it is imperative to investigate the genetic characteristics of Guanzhong Han population using enhanced Y-chromosomal short tandem repeats (Y-STR) detecting system with higher discriminating power than previous ones.

METHODS

In this study, 38 Y-STRs were profiled in 430 unrelated Chinese Han male individuals from Guanzhong region of Shaanxi Province, Northwest China, using the Yfiler™ Platinum PCR Amplification Kit. Haplotype frequencies and forensic parameters were calculated. Comprehensive population comparisons with geographically/ethnically different populations in China and other worldwide countries were performed.

RESULTS

A total of 422 different haplotypes were observed with the overall haplotype diversity (HD), discriminatory power (DC) and haplotype match probability (HMP) were 0.9999, 0.9814, and 0.0024, respectively. Guanzhong Han showed genetically affinity with Han ethnicity from Shanxi and Henan provinces, while far distant from Tibetan populations.

CONCLUSION

This study offered a unique insight into Guanzhong Han population, the 38 Y-STRs included in the the Yfiler™ Platinum system are highly polymorphic and informative and can be used for forensic practice and human genetic research.

Links

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Authors+Show Affiliations

Li L
Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yao L
Center of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, Guizhou, China.
He X
Department of Mathematics, Sichuan University, Chengdu, Sichuan, China.
Gong H
Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Deng Y
Department of Pathology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Luan M
Department of Dermatology and Venerology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
He G
Institute of Forensic medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China.
Jia F
Department of Forensic Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.
Chen P
Center of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, Guizhou, China.

MeSH

ChinaChromosomes, Human, YEthnicityForensic GeneticsGenotyping TechniquesHaplotypesHumansMaleMicrosatellite RepeatsPhylogenyPolymorphism, GeneticPopulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32166867

Citation

Li, Luyao, et al. "Haplotype Diversity and Phylogenetic Characteristics for Guanzhong Han Population From Northwest China Via 38 Y-STRs Using Yfiler™ Platinum Amplification System." Molecular Genetics & Genomic Medicine, vol. 8, no. 5, 2020, pp. e1187.
Li L, Yao L, He X, et al. Haplotype diversity and phylogenetic characteristics for Guanzhong Han population from Northwest China via 38 Y-STRs using Yfiler™ Platinum Amplification System. Mol Genet Genomic Med. 2020;8(5):e1187.
Li, L., Yao, L., He, X., Gong, H., Deng, Y., Luan, M., He, G., Jia, F., & Chen, P. (2020). Haplotype diversity and phylogenetic characteristics for Guanzhong Han population from Northwest China via 38 Y-STRs using Yfiler™ Platinum Amplification System. Molecular Genetics & Genomic Medicine, 8(5), e1187. https://doi.org/10.1002/mgg3.1187
Li L, et al. Haplotype Diversity and Phylogenetic Characteristics for Guanzhong Han Population From Northwest China Via 38 Y-STRs Using Yfiler™ Platinum Amplification System. Mol Genet Genomic Med. 2020;8(5):e1187. PubMed PMID: 32166867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haplotype diversity and phylogenetic characteristics for Guanzhong Han population from Northwest China via 38 Y-STRs using Yfiler™ Platinum Amplification System. AU - Li,Luyao, AU - Yao,Lilan, AU - He,Xin, AU - Gong,Huilin, AU - Deng,Yuan, AU - Luan,Mei, AU - He,Guanglin, AU - Jia,Fuquan, AU - Chen,Pengyu, Y1 - 2020/03/12/ PY - 2019/12/06/received PY - 2020/02/04/revised PY - 2020/02/05/accepted PY - 2020/3/14/pubmed PY - 2021/4/7/medline PY - 2020/3/14/entrez KW - Guanzhong Han population KW - Y-chromosomal STR KW - Yfiler™ Platinum system KW - forensic genetics KW - genetic diversity SP - e1187 EP - e1187 JF - Molecular genetics & genomic medicine JO - Mol Genet Genomic Med VL - 8 IS - 5 N2 - BACKGROUND: For better application in human forensic cases and population genetics research, it is imperative to investigate the genetic characteristics of Guanzhong Han population using enhanced Y-chromosomal short tandem repeats (Y-STR) detecting system with higher discriminating power than previous ones. METHODS: In this study, 38 Y-STRs were profiled in 430 unrelated Chinese Han male individuals from Guanzhong region of Shaanxi Province, Northwest China, using the Yfiler™ Platinum PCR Amplification Kit. Haplotype frequencies and forensic parameters were calculated. Comprehensive population comparisons with geographically/ethnically different populations in China and other worldwide countries were performed. RESULTS: A total of 422 different haplotypes were observed with the overall haplotype diversity (HD), discriminatory power (DC) and haplotype match probability (HMP) were 0.9999, 0.9814, and 0.0024, respectively. Guanzhong Han showed genetically affinity with Han ethnicity from Shanxi and Henan provinces, while far distant from Tibetan populations. CONCLUSION: This study offered a unique insight into Guanzhong Han population, the 38 Y-STRs included in the the Yfiler™ Platinum system are highly polymorphic and informative and can be used for forensic practice and human genetic research. SN - 2324-9269 UR - https://www.unboundmedicine.com/medline/citation/32166867/Haplotype_diversity_and_phylogenetic_characteristics_for_Guanzhong_Han_population_from_Northwest_China_via_38_Y_STRs_using_Yfiler™_Platinum_Amplification_System_ DB - PRIME DP - Unbound Medicine ER -