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Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.
ACS Chem Neurosci. 2020 04 01; 11(7):995-998.AC

Abstract

The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin-converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host-virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement.

Authors+Show Affiliations

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.Medical College, Aga Khan University, Karachi 74800, Pakistan.Department of Biosciences, Mohammad Ali Jinnah University, Karachi 75400, Pakistan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32167747

Citation

Baig, Abdul Mannan, et al. "Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms." ACS Chemical Neuroscience, vol. 11, no. 7, 2020, pp. 995-998.
Baig AM, Khaleeq A, Ali U, et al. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci. 2020;11(7):995-998.
Baig, A. M., Khaleeq, A., Ali, U., & Syeda, H. (2020). Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chemical Neuroscience, 11(7), 995-998. https://doi.org/10.1021/acschemneuro.0c00122
Baig AM, et al. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci. 2020 04 1;11(7):995-998. PubMed PMID: 32167747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. AU - Baig,Abdul Mannan, AU - Khaleeq,Areeba, AU - Ali,Usman, AU - Syeda,Hira, Y1 - 2020/03/13/ PY - 2020/3/14/pubmed PY - 2020/4/9/medline PY - 2020/3/14/entrez KW - ACE2 tissue distribution KW - COVID-19 KW - Coronavirus KW - SARS-CoV-2 KW - host−virus interaction KW - spike protein SP - 995 EP - 998 JF - ACS chemical neuroscience JO - ACS Chem Neurosci VL - 11 IS - 7 N2 - The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin-converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host-virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement. SN - 1948-7193 UR - https://www.unboundmedicine.com/medline/citation/32167747/full_citation L2 - https://doi.org/10.1021/acschemneuro.0c00122 DB - PRIME DP - Unbound Medicine ER -