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Extracellular vesicle therapy for retinal diseases.
Prog Retin Eye Res. 2020 Mar 10 [Online ahead of print]PR

Abstract

Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this expansive cargo into nearby cells as well as over long distances via the blood stream. Great interest has been given to them for their role in cell to cell communication, disease progression, or as biomarkers, and more recent studies have interrogated their potential as a therapeutic that may replace paracrine-acting cell therapies. The retina is a conveniently accessible component of the central nervous system and the proposed paradigm for the testing of many cell therapies. Recently, several studies have been published demonstrating that the delivery of EV/exosomes into the eye can elicit significant therapeutic effects in several models of retinal disease. We summarize results from currently available studies, demonstrating their efficacy in multiple eye disease models as well as highlighting where future research efforts should be directed.

Authors+Show Affiliations

School of Optometry and Vision Sciences, Cardiff University, Cardiff, CF24 4HQ, UK. Electronic address: meadb@cardiff.ac.uk.Section of Retinal Ganglion Cell Biology, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institute of Health, Bethesda, MD, 20892, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32169632

Citation

Mead, Ben, and Stanislav Tomarev. "Extracellular Vesicle Therapy for Retinal Diseases." Progress in Retinal and Eye Research, 2020, p. 100849.
Mead B, Tomarev S. Extracellular vesicle therapy for retinal diseases. Prog Retin Eye Res. 2020.
Mead, B., & Tomarev, S. (2020). Extracellular vesicle therapy for retinal diseases. Progress in Retinal and Eye Research, 100849. https://doi.org/10.1016/j.preteyeres.2020.100849
Mead B, Tomarev S. Extracellular Vesicle Therapy for Retinal Diseases. Prog Retin Eye Res. 2020 Mar 10;100849. PubMed PMID: 32169632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracellular vesicle therapy for retinal diseases. AU - Mead,Ben, AU - Tomarev,Stanislav, Y1 - 2020/03/10/ PY - 2019/12/19/received PY - 2020/03/03/revised PY - 2020/03/06/accepted PY - 2020/3/15/pubmed PY - 2020/3/15/medline PY - 2020/3/15/entrez KW - Exosomes KW - Extracellular vesicles KW - Glaucoma KW - Mesenchymal stem cells KW - Optic nerve crush KW - Retina SP - 100849 EP - 100849 JF - Progress in retinal and eye research JO - Prog Retin Eye Res N2 - Extracellular vesicles (EV), which include exosomes and microvesicles, are secreted from virtually every cell. EV contain mRNA, miRNA, lipids and proteins and can deliver this expansive cargo into nearby cells as well as over long distances via the blood stream. Great interest has been given to them for their role in cell to cell communication, disease progression, or as biomarkers, and more recent studies have interrogated their potential as a therapeutic that may replace paracrine-acting cell therapies. The retina is a conveniently accessible component of the central nervous system and the proposed paradigm for the testing of many cell therapies. Recently, several studies have been published demonstrating that the delivery of EV/exosomes into the eye can elicit significant therapeutic effects in several models of retinal disease. We summarize results from currently available studies, demonstrating their efficacy in multiple eye disease models as well as highlighting where future research efforts should be directed. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/32169632/Extracellular_vesicle_therapy_for_retinal_diseases L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(20)30021-5 DB - PRIME DP - Unbound Medicine ER -
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