Tags

Type your tag names separated by a space and hit enter

Liver injury during highly pathogenic human coronavirus infections.
Liver Int. 2020 05; 40(5):998-1004.LI

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), the pathogen of 2019 novel coronavirus disease (COVID-19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS-CoV-2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS-CoV-2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus - severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS-CoV, MERS-CoV as well as SARS-CoV-2 infection were summarized, which may provide help for further studies on the liver injury of COVID-19.

Authors+Show Affiliations

Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China. Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32170806

Citation

Xu, Ling, et al. "Liver Injury During Highly Pathogenic Human Coronavirus Infections." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 40, no. 5, 2020, pp. 998-1004.
Xu L, Liu J, Lu M, et al. Liver injury during highly pathogenic human coronavirus infections. Liver Int. 2020;40(5):998-1004.
Xu, L., Liu, J., Lu, M., Yang, D., & Zheng, X. (2020). Liver injury during highly pathogenic human coronavirus infections. Liver International : Official Journal of the International Association for the Study of the Liver, 40(5), 998-1004. https://doi.org/10.1111/liv.14435
Xu L, et al. Liver Injury During Highly Pathogenic Human Coronavirus Infections. Liver Int. 2020;40(5):998-1004. PubMed PMID: 32170806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liver injury during highly pathogenic human coronavirus infections. AU - Xu,Ling, AU - Liu,Jia, AU - Lu,Mengji, AU - Yang,Dongliang, AU - Zheng,Xin, Y1 - 2020/03/30/ PY - 2020/02/29/received PY - 2020/03/09/revised PY - 2020/03/10/accepted PY - 2020/3/15/pubmed PY - 2020/5/6/medline PY - 2020/3/15/entrez KW - COVID-19 KW - MERS KW - SARS KW - SARS-CoV-2 KW - liver injury SP - 998 EP - 1004 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int. VL - 40 IS - 5 N2 - The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), the pathogen of 2019 novel coronavirus disease (COVID-19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS-CoV-2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS-CoV-2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus - severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS-CoV, MERS-CoV as well as SARS-CoV-2 infection were summarized, which may provide help for further studies on the liver injury of COVID-19. SN - 1478-3231 UR - https://www.unboundmedicine.com/medline/citation/32170806/Liver_injury_during_highly_pathogenic_human_coronavirus_infections_ L2 - https://doi.org/10.1111/liv.14435 DB - PRIME DP - Unbound Medicine ER -