Tags

Type your tag names separated by a space and hit enter

A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.
J Crit Care. 2020 Mar 10 [Online ahead of print]JC

Abstract

PURPOSE

COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19.

METHODS

PubMed, EMBASE, and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19.

RESULTS

We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro.

CONCLUSIONS

There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed.

Authors+Show Affiliations

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy. Electronic address: andrea.cortegiani@unipa.it.Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy.Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem, Israel.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32173110

Citation

Cortegiani, Andrea, et al. "A Systematic Review On the Efficacy and Safety of Chloroquine for the Treatment of COVID-19." Journal of Critical Care, 2020.
Cortegiani A, Ingoglia G, Ippolito M, et al. A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. J Crit Care. 2020.
Cortegiani, A., Ingoglia, G., Ippolito, M., Giarratano, A., & Einav, S. (2020). A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. Journal of Critical Care. https://doi.org/10.1016/j.jcrc.2020.03.005
Cortegiani A, et al. A Systematic Review On the Efficacy and Safety of Chloroquine for the Treatment of COVID-19. J Crit Care. 2020 Mar 10; PubMed PMID: 32173110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19. AU - Cortegiani,Andrea, AU - Ingoglia,Giulia, AU - Ippolito,Mariachiara, AU - Giarratano,Antonino, AU - Einav,Sharon, Y1 - 2020/03/10/ PY - 2020/03/03/received PY - 2020/03/06/revised PY - 2020/03/08/accepted PY - 2020/3/17/entrez PY - 2020/3/17/pubmed PY - 2020/3/17/medline KW - COVID-19 KW - Chloroquine KW - Coronavirus KW - Pneumonia KW - SARS-CoV-2 JF - Journal of critical care JO - J Crit Care N2 - PURPOSE: COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19. METHODS: PubMed, EMBASE, and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19. RESULTS: We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro. CONCLUSIONS: There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed. SN - 1557-8615 UR - https://www.unboundmedicine.com/medline/citation/32173110/A_systematic_review_on_the_efficacy_and_safety_of_chloroquine_for_the_treatment_of_COVID-19 L2 - https://linkinghub.elsevier.com/retrieve/pii/S0883-9441(20)30390-7 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.