Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients.AJR Am J Roentgenol. 2020 07; 215(1):87-93.AA
Abstract
OBJECTIVE.
Available information on CT features of the 2019 novel coronavirus disease (COVID-19) is scattered in different publications, and a cohesive literature review has yet to be compiled. MATERIALS ANDMETHODS.
This article includes a systematic literature search of PubMed, Embase (Elsevier), Google Scholar, and the World Health Organization database.RESULTS.
Known features of COVID-19 on initial CT include bilateral multilobar ground-glass opacification (GGO) with a peripheral or posterior distribution, mainly in the lower lobes and less frequently within the right middle lobe. Atypical initial imaging presentation of consolidative opacities superimposed on GGO may be found in a smaller number of cases, mainly in the elderly population. Septal thickening, bronchiectasis, pleural thickening, and subpleural involvement are some of the less common findings, mainly in the later stages of the disease. Pleural effusion, pericardial effusion, lymphadenopathy, cavitation, CT halo sign, and pneumothorax are uncommon but may be seen with disease progression. Follow-up CT in the intermediate stage of disease shows an increase in the number and size of GGOs and progressive transformation of GGO into multifocal consolidative opacities, septal thickening, and development of a crazy paving pattern, with the greatest severity of CT findings visible around day 10 after the symptom onset. Acute respiratory distress syndrome is the most common indication for transferring patients with COVID-19 to the ICU and the major cause of death in this patient population. Imaging patterns corresponding to clinical improvement usually occur after week 2 of the disease and include gradual resolution of consolidative opacities and decrease in the number of lesions and involved lobes.CONCLUSION.
This systematic review of current literature on COVID-19 provides insight into the initial and follow-up CT characteristics of the disease.Links
MeSH
Pub Type(s)
Journal Article
Systematic Review
Language
eng
PubMed ID
32174129
Clinical Trial Links
Citation
Salehi, Sana, et al. "Coronavirus Disease 2019 (COVID-19): a Systematic Review of Imaging Findings in 919 Patients." AJR. American Journal of Roentgenology, vol. 215, no. 1, 2020, pp. 87-93.
Salehi S, Abedi A, Balakrishnan S, et al. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol. 2020;215(1):87-93.
Salehi, S., Abedi, A., Balakrishnan, S., & Gholamrezanezhad, A. (2020). Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. AJR. American Journal of Roentgenology, 215(1), 87-93. https://doi.org/10.2214/AJR.20.23034
Salehi S, et al. Coronavirus Disease 2019 (COVID-19): a Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol. 2020;215(1):87-93. PubMed PMID: 32174129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients.
AU - Salehi,Sana,
AU - Abedi,Aidin,
AU - Balakrishnan,Sudheer,
AU - Gholamrezanezhad,Ali,
Y1 - 2020/03/14/
PY - 2020/3/17/pubmed
PY - 2020/7/3/medline
PY - 2020/3/17/entrez
KW - 2019-nCoV
KW - COVID-19
KW - CT scan
KW - coronavirus
KW - influenza
KW - outbreak
KW - pneumonia
KW - radiology
KW - systematic review
KW - viral
SP - 87
EP - 93
JF - AJR. American journal of roentgenology
JO - AJR Am J Roentgenol
VL - 215
IS - 1
N2 - OBJECTIVE. Available information on CT features of the 2019 novel coronavirus disease (COVID-19) is scattered in different publications, and a cohesive literature review has yet to be compiled. MATERIALS AND METHODS. This article includes a systematic literature search of PubMed, Embase (Elsevier), Google Scholar, and the World Health Organization database. RESULTS. Known features of COVID-19 on initial CT include bilateral multilobar ground-glass opacification (GGO) with a peripheral or posterior distribution, mainly in the lower lobes and less frequently within the right middle lobe. Atypical initial imaging presentation of consolidative opacities superimposed on GGO may be found in a smaller number of cases, mainly in the elderly population. Septal thickening, bronchiectasis, pleural thickening, and subpleural involvement are some of the less common findings, mainly in the later stages of the disease. Pleural effusion, pericardial effusion, lymphadenopathy, cavitation, CT halo sign, and pneumothorax are uncommon but may be seen with disease progression. Follow-up CT in the intermediate stage of disease shows an increase in the number and size of GGOs and progressive transformation of GGO into multifocal consolidative opacities, septal thickening, and development of a crazy paving pattern, with the greatest severity of CT findings visible around day 10 after the symptom onset. Acute respiratory distress syndrome is the most common indication for transferring patients with COVID-19 to the ICU and the major cause of death in this patient population. Imaging patterns corresponding to clinical improvement usually occur after week 2 of the disease and include gradual resolution of consolidative opacities and decrease in the number of lesions and involved lobes. CONCLUSION. This systematic review of current literature on COVID-19 provides insight into the initial and follow-up CT characteristics of the disease.
SN - 1546-3141
UR - https://www.unboundmedicine.com/medline/citation/32174129/Coronavirus_Disease_2019__COVID_19_:_A_Systematic_Review_of_Imaging_Findings_in_919_Patients_
L2 - https://www.ajronline.org/doi/10.2214/AJR.20.23034
DB - PRIME
DP - Unbound Medicine
ER -