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Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults.
Nutrients. 2020 Mar 12; 12(3)N

Abstract

BACKGROUND

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios.

AIMS

We compared the effects of fish oil supplements with different EPA/DHA ratios on lipoprotein metabolism.

METHODS

In a double-blind, randomized cross-over study, normolipidemic adults (n = 30) consumed 12 g/day of EPA-rich (EPA/DHA: 2.3) or DHA-rich (EPA/DHA: 0.3) fish oil for 8-weeks, separated by an 8-week washout period.

RESULTS

Both fish oil supplements similarly lowered plasma TG levels and TG-related NMR parameters versus baseline (p < 0.05). There were no changes in plasma cholesterol-related parameters due to either fish oil, although on-treatment levels for LDL particle number were slightly higher for DHA-rich oil compared with EPA-rich oil (p < 0.05). Both fish oil supplements similarly altered HDL subclass profile and proteome, and down regulated HDL proteins related to inflammation, with EPA-rich oil to a greater extent. Furthermore, EPA-rich oil increased apoM abundance versus DHA-rich oil (p < 0.05).

CONCLUSIONS

Overall, fish oil supplements with varied EPA/DHA ratios had similar effects on total lipids/lipoproteins, but differences were observed in lipoprotein subfraction composition and distribution, which could impact on the use of EPA versus DHA for improving cardiovascular health.

Authors+Show Affiliations

Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA.Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA.Clinical Center, Department of Laboratory Medicine, NIH, Bethesda, MD 20814, USA.Clinical Center, Nutrition Department, NIH, Bethesda, MD 20814, USA.Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA.Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA. Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky College of Medicine, Lexington, KY 40506, USA.Proteomics Core, Cardiovascular Branch, NHLBI, NIH, Bethesda, MD 20814, USA.Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA.Section of Inflammation and Cardiometabolic Diseases, Cardiovascular Branch, NHLBI, NIH, Bethesda, MD 20814, USA.Office of Biostatistics Research, NHLBI, NIH, Bethesda, MD 20814, USA.Clinical Center, Nutrition Department, NIH, Bethesda, MD 20814, USA.Section of Inflammation and Cardiometabolic Diseases, Cardiovascular Branch, NHLBI, NIH, Bethesda, MD 20814, USA.Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

32178279

Citation

Yang, Zhi-Hong, et al. "Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation On Plasma Lipids and Lipoproteins in Normolipidemic Adults." Nutrients, vol. 12, no. 3, 2020.
Yang ZH, Amar M, Sampson M, et al. Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults. Nutrients. 2020;12(3).
Yang, Z. H., Amar, M., Sampson, M., Courville, A. B., Sorokin, A. V., Gordon, S. M., Aponte, A. M., Stagliano, M., Playford, M. P., Fu, Y. P., Yang, S., Mehta, N. N., & Remaley, A. T. (2020). Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults. Nutrients, 12(3). https://doi.org/10.3390/nu12030749
Yang ZH, et al. Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation On Plasma Lipids and Lipoproteins in Normolipidemic Adults. Nutrients. 2020 Mar 12;12(3) PubMed PMID: 32178279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Omega-3 Eicosapentaenoic Acid Versus Docosahexaenoic Acid-Rich Fish Oil Supplementation on Plasma Lipids and Lipoproteins in Normolipidemic Adults. AU - Yang,Zhi-Hong, AU - Amar,Marcelo, AU - Sampson,Maureen, AU - Courville,Amber B, AU - Sorokin,Alexander V, AU - Gordon,Scott M, AU - Aponte,Angel M, AU - Stagliano,Michael, AU - Playford,Martin P, AU - Fu,Yi-Ping, AU - Yang,Shanna, AU - Mehta,Nehal N, AU - Remaley,Alan T, Y1 - 2020/03/12/ PY - 2020/02/13/received PY - 2020/03/05/revised PY - 2020/03/08/accepted PY - 2020/3/18/entrez PY - 2020/3/18/pubmed PY - 2020/3/18/medline KW - HDL cholesterol KW - LDL cholesterol KW - docosahexaenoic acid (DHA) KW - eicosapentaenoic acid (EPA) KW - lipoprotein metabolism KW - omega-3 fatty acids KW - triglyceride JF - Nutrients JO - Nutrients VL - 12 IS - 3 N2 - BACKGROUND: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have both shared and different cardiovascular effects, and commonly used fish oil supplements have considerably varied EPA/DHA ratios. AIMS: We compared the effects of fish oil supplements with different EPA/DHA ratios on lipoprotein metabolism. METHODS: In a double-blind, randomized cross-over study, normolipidemic adults (n = 30) consumed 12 g/day of EPA-rich (EPA/DHA: 2.3) or DHA-rich (EPA/DHA: 0.3) fish oil for 8-weeks, separated by an 8-week washout period. RESULTS: Both fish oil supplements similarly lowered plasma TG levels and TG-related NMR parameters versus baseline (p < 0.05). There were no changes in plasma cholesterol-related parameters due to either fish oil, although on-treatment levels for LDL particle number were slightly higher for DHA-rich oil compared with EPA-rich oil (p < 0.05). Both fish oil supplements similarly altered HDL subclass profile and proteome, and down regulated HDL proteins related to inflammation, with EPA-rich oil to a greater extent. Furthermore, EPA-rich oil increased apoM abundance versus DHA-rich oil (p < 0.05). CONCLUSIONS: Overall, fish oil supplements with varied EPA/DHA ratios had similar effects on total lipids/lipoproteins, but differences were observed in lipoprotein subfraction composition and distribution, which could impact on the use of EPA versus DHA for improving cardiovascular health. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32178279/Comparison_of_Omega_3_Eicosapentaenoic_Acid_Versus_Docosahexaenoic_Acid_Rich_Fish_Oil_Supplementation_on_Plasma_Lipids_and_Lipoproteins_in_Normolipidemic_Adults_ L2 - https://www.mdpi.com/resolver?pii=nu12030749 DB - PRIME DP - Unbound Medicine ER -