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PAMPs of the Fungal Cell Wall and Mammalian PRRs.
Curr Top Microbiol Immunol. 2020; 425:187-223.CT

Abstract

Fungi are opportunistic pathogens that infect immunocompromised patients and are responsible for an estimated 1.5 million deaths every year. The antifungal innate immune response is mediated through the recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). PRRs are immune receptors that ensure the internalisation and the killing of fungal pathogens. They also mount the inflammatory response, which contributes to initiate and polarise the adaptive response, controlled by lymphocytes. Both the innate and adaptive immune responses are required to control fungal infections. The immune recognition of fungal pathogen primarily occurs at the interface between the membrane of innate immune cells and the fungal cell wall, which contains a number of PAMPs. This chapter will focus on describing the main mammalian PRRs that have been shown to bind to PAMPs from the fungal cell wall of the four main fungal pathogens: Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans and Pneumocystis jirovecii. We will describe these receptors, their functions and ligands to provide the reader with an overview of how the immune system recognises fungal pathogens and responds to them.

Authors+Show Affiliations

MRC Centre for Medical Mycology at University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, UK.MRC Centre for Medical Mycology at University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, UK.MRC Centre for Medical Mycology at University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, UK. Gordon.brown@exeter.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32180018

Citation

Hatinguais, Remi, et al. "PAMPs of the Fungal Cell Wall and Mammalian PRRs." Current Topics in Microbiology and Immunology, vol. 425, 2020, pp. 187-223.
Hatinguais R, Willment JA, Brown GD. PAMPs of the Fungal Cell Wall and Mammalian PRRs. Curr Top Microbiol Immunol. 2020;425:187-223.
Hatinguais, R., Willment, J. A., & Brown, G. D. (2020). PAMPs of the Fungal Cell Wall and Mammalian PRRs. Current Topics in Microbiology and Immunology, 425, 187-223. https://doi.org/10.1007/82_2020_201
Hatinguais R, Willment JA, Brown GD. PAMPs of the Fungal Cell Wall and Mammalian PRRs. Curr Top Microbiol Immunol. 2020;425:187-223. PubMed PMID: 32180018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PAMPs of the Fungal Cell Wall and Mammalian PRRs. AU - Hatinguais,Remi, AU - Willment,Janet A, AU - Brown,Gordon D, PY - 2020/3/18/pubmed PY - 2020/3/18/medline PY - 2020/3/18/entrez SP - 187 EP - 223 JF - Current topics in microbiology and immunology JO - Curr. Top. Microbiol. Immunol. VL - 425 N2 - Fungi are opportunistic pathogens that infect immunocompromised patients and are responsible for an estimated 1.5 million deaths every year. The antifungal innate immune response is mediated through the recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). PRRs are immune receptors that ensure the internalisation and the killing of fungal pathogens. They also mount the inflammatory response, which contributes to initiate and polarise the adaptive response, controlled by lymphocytes. Both the innate and adaptive immune responses are required to control fungal infections. The immune recognition of fungal pathogen primarily occurs at the interface between the membrane of innate immune cells and the fungal cell wall, which contains a number of PAMPs. This chapter will focus on describing the main mammalian PRRs that have been shown to bind to PAMPs from the fungal cell wall of the four main fungal pathogens: Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans and Pneumocystis jirovecii. We will describe these receptors, their functions and ligands to provide the reader with an overview of how the immune system recognises fungal pathogens and responds to them. SN - 0070-217X UR - https://www.unboundmedicine.com/medline/citation/32180018/PAMPs_of_the_Fungal_Cell_Wall_and_Mammalian_PRRs_ L2 - https://doi.org/10.1007/82_2020_201 DB - PRIME DP - Unbound Medicine ER -
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