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A field trial in Belgium to control fox rabies by oral immunisation.
Vet Rec. 1988 Dec 10; 123(24):618-21.VR

Abstract

Campaigns of fox vaccination against rabies were carried out in Belgium in September 1986 and June and September 1987. The SAD B19 attenuated strain of rabies virus was inserted into baits which were distributed over an area of 2100 km2 at a density of 11 baits/km2. As recommended by the World Health Organisation, the efficacy and the innocuity of the method were controlled in the field and in the laboratory. Samples of blood and brain and jaw were taken from foxes which were shot or found dead in the vaccination area, for the diagnosis of rabies, the titration of antirabies antibody and the detection of tetracycline marker. In rabid animals, the virus strain was characterised by immunofluorescence using monoclonal antibodies. In September 1987, the uptake of the baits had reached 72 per cent by 14 days after distribution. Several wild species competed with foxes in taking the baits. After the last campaign, tetracycline was found in 65 per cent of the healthy foxes collected and rabies virus neutralising antibodies were detected in 77 per cent of them. In 1987, the incidence of rabies decreased markedly in the vaccination area compared with the untreated areas. No vaccine virus was isolated either from rabid animals or from 228 small mammals trapped in the vaccination area.

Authors+Show Affiliations

Department of Virology, Faculty of Veterinary Medicine, University of Liège, Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3218039

Citation

Brochier, B, et al. "A Field Trial in Belgium to Control Fox Rabies By Oral Immunisation." The Veterinary Record, vol. 123, no. 24, 1988, pp. 618-21.
Brochier B, Thomas I, Iokem A, et al. A field trial in Belgium to control fox rabies by oral immunisation. Vet Rec. 1988;123(24):618-21.
Brochier, B., Thomas, I., Iokem, A., Ginter, A., Kalpers, J., Paquot, A., Costy, F., & Pastoret, P. P. (1988). A field trial in Belgium to control fox rabies by oral immunisation. The Veterinary Record, 123(24), 618-21.
Brochier B, et al. A Field Trial in Belgium to Control Fox Rabies By Oral Immunisation. Vet Rec. 1988 Dec 10;123(24):618-21. PubMed PMID: 3218039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A field trial in Belgium to control fox rabies by oral immunisation. AU - Brochier,B, AU - Thomas,I, AU - Iokem,A, AU - Ginter,A, AU - Kalpers,J, AU - Paquot,A, AU - Costy,F, AU - Pastoret,P P, PY - 1988/12/10/pubmed PY - 1988/12/10/medline PY - 1988/12/10/entrez SP - 618 EP - 21 JF - The Veterinary record JO - Vet Rec VL - 123 IS - 24 N2 - Campaigns of fox vaccination against rabies were carried out in Belgium in September 1986 and June and September 1987. The SAD B19 attenuated strain of rabies virus was inserted into baits which were distributed over an area of 2100 km2 at a density of 11 baits/km2. As recommended by the World Health Organisation, the efficacy and the innocuity of the method were controlled in the field and in the laboratory. Samples of blood and brain and jaw were taken from foxes which were shot or found dead in the vaccination area, for the diagnosis of rabies, the titration of antirabies antibody and the detection of tetracycline marker. In rabid animals, the virus strain was characterised by immunofluorescence using monoclonal antibodies. In September 1987, the uptake of the baits had reached 72 per cent by 14 days after distribution. Several wild species competed with foxes in taking the baits. After the last campaign, tetracycline was found in 65 per cent of the healthy foxes collected and rabies virus neutralising antibodies were detected in 77 per cent of them. In 1987, the incidence of rabies decreased markedly in the vaccination area compared with the untreated areas. No vaccine virus was isolated either from rabid animals or from 228 small mammals trapped in the vaccination area. SN - 0042-4900 UR - https://www.unboundmedicine.com/medline/citation/3218039/A_field_trial_in_Belgium_to_control_fox_rabies_by_oral_immunisation_ L2 - https://medlineplus.gov/rabies.html DB - PRIME DP - Unbound Medicine ER -