Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia.AJR Am J Roentgenol. 2020 08; 215(2):338-343.AA
Abstract
OBJECTIVE.
The purpose of this study was to investigate early clinical and CT manifestations of coronavirus disease (COVID-19) pneumonia. MATERIALS ANDMETHODS.
Patients with COVID-19 pneumonia confirmed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test (reverse transcription-polymerase chain reaction) were enrolled in this retrospective study. The clinical manifestations, laboratory results, and CT findings were evaluated.RESULTS.
One hundred eight patients (38 men, 70 women; age range, 21-90 years) were included in the study. The clinical manifestations were fever in 94 of 108 (87%) patients, dry cough in 65 (60%), and fatigue in 42 (39%). The laboratory results were normal WBC count in 97 (90%) patients and normal or reduced lymphocyte count in 65 (60%). High-sensitivity C-reactive protein level was elevated in 107 (99%) patients. The distribution of involved lobes was one lobe in 38 (35%) patients, two or three lobes in 24 (22%), and four or five lobes in 46 (43%). The major involvement was peripheral (97 patients [90%]), and the common lesion shape was patchy (93 patients [86%]). Sixty-five (60%) patients had ground-glass opacity (GGO), and 44 (41%) had GGO with consolidation. The size of lesions varied from smaller than 1 cm (10 patients [9%]) to larger than 3 cm (56 patients [52%]). Vascular thickening (86 patients [80%]), crazy paving pattern (43 patients [40%]), air bronchogram sign (52 patients [48%]), and halo sign (69 [64%]) were also observed in this study.CONCLUSION.
The early clinical and laboratory findings of COVID-19 pneumonia are low to midgrade fever, dry cough, and fatigue with normal WBC count, reduced lymphocyte count, and elevated high-sensitivity C-reactive protein level. The early CT findings are patchy GGO with or without consolidation involving multiple lobes, mainly in the peripheral zone, accompanied by halo sign, vascular thickening, crazy paving pattern, or air bronchogram sign.Links
MeSH
Pub Type(s)
Journal Article
Language
eng
PubMed ID
32181672
Citation
Han, Rui, et al. "Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia." AJR. American Journal of Roentgenology, vol. 215, no. 2, 2020, pp. 338-343.
Han R, Huang L, Jiang H, et al. Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia. AJR Am J Roentgenol. 2020;215(2):338-343.
Han, R., Huang, L., Jiang, H., Dong, J., Peng, H., & Zhang, D. (2020). Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia. AJR. American Journal of Roentgenology, 215(2), 338-343. https://doi.org/10.2214/AJR.20.22961
Han R, et al. Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia. AJR Am J Roentgenol. 2020;215(2):338-343. PubMed PMID: 32181672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia.
AU - Han,Rui,
AU - Huang,Lu,
AU - Jiang,Hong,
AU - Dong,Jin,
AU - Peng,Hongfen,
AU - Zhang,Dongyou,
Y1 - 2020/03/17/
PY - 2020/3/18/pubmed
PY - 2020/8/15/medline
PY - 2020/3/18/entrez
KW - COVID-19
KW - CT
KW - SARS-CoV-2
KW - clinical manifestations
KW - coronavirus
KW - pneumonia
SP - 338
EP - 343
JF - AJR. American journal of roentgenology
JO - AJR Am J Roentgenol
VL - 215
IS - 2
N2 - OBJECTIVE. The purpose of this study was to investigate early clinical and CT manifestations of coronavirus disease (COVID-19) pneumonia. MATERIALS AND METHODS. Patients with COVID-19 pneumonia confirmed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test (reverse transcription-polymerase chain reaction) were enrolled in this retrospective study. The clinical manifestations, laboratory results, and CT findings were evaluated. RESULTS. One hundred eight patients (38 men, 70 women; age range, 21-90 years) were included in the study. The clinical manifestations were fever in 94 of 108 (87%) patients, dry cough in 65 (60%), and fatigue in 42 (39%). The laboratory results were normal WBC count in 97 (90%) patients and normal or reduced lymphocyte count in 65 (60%). High-sensitivity C-reactive protein level was elevated in 107 (99%) patients. The distribution of involved lobes was one lobe in 38 (35%) patients, two or three lobes in 24 (22%), and four or five lobes in 46 (43%). The major involvement was peripheral (97 patients [90%]), and the common lesion shape was patchy (93 patients [86%]). Sixty-five (60%) patients had ground-glass opacity (GGO), and 44 (41%) had GGO with consolidation. The size of lesions varied from smaller than 1 cm (10 patients [9%]) to larger than 3 cm (56 patients [52%]). Vascular thickening (86 patients [80%]), crazy paving pattern (43 patients [40%]), air bronchogram sign (52 patients [48%]), and halo sign (69 [64%]) were also observed in this study. CONCLUSION. The early clinical and laboratory findings of COVID-19 pneumonia are low to midgrade fever, dry cough, and fatigue with normal WBC count, reduced lymphocyte count, and elevated high-sensitivity C-reactive protein level. The early CT findings are patchy GGO with or without consolidation involving multiple lobes, mainly in the peripheral zone, accompanied by halo sign, vascular thickening, crazy paving pattern, or air bronchogram sign.
SN - 1546-3141
UR - https://www.unboundmedicine.com/medline/citation/32181672/Early_Clinical_and_CT_Manifestations_of_Coronavirus_Disease_2019__COVID_19__Pneumonia_
L2 - https://www.ajronline.org/doi/10.2214/AJR.20.22961
DB - PRIME
DP - Unbound Medicine
ER -