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Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD).
Osteoarthritis Cartilage. 2020 06; 28(6):792-801.OC

Abstract

OBJECTIVE

This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database.

DESIGN

The UK Clinical Practice Research Datalink (CPRD) comprising data on nearly 17.5 million patients was used for the study. The incidence and prevalence of general practitioner diagnosed OA over a 20 years period (1997-2017) were estimated and age-sex and length of data contribution standardized using the 2017 CPRD population structure. Cohort effects were examined through Age-period-cohort analysis.

RESULTS

During 1997-2017, there were 494,716 incident OA cases aged ≥20 years. The standardised incidence of any OA in 2017 was 6.8 per 1000 person-years (95% CI 6.7 to 6.9) and prevalence was 10.7% (95% CI 10.7-10.8%). Both incidence and prevalence were higher in women than men. The incidence of any-OA decreased gradually in the past 20 years at an annual rate of -1.6% (95%CI -2.0 to -1.1%), and the reduction speeded up for people born after 1960. The prevalence of any-OA increased gradually at an annual rate of 1.4% (95% CI 1.3-1.6%). Although the prevalence was highest in Scotland and Northern Ireland, incidence was highest in the East Midlands. Both incidence and prevalence reported highest in the knee followed by hip, wrist/hand and ankle/foot.

CONCLUSION

In the UK approximately one in 10 adults have symptomatic clinically diagnosed OA, the knee being the commonest. While prevalence has increased and become static after 2008, incidence is slowly declining. Further research is required to understand these changes.

Authors+Show Affiliations

Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, UK; Versus Arthritis Pain Centre, University of Nottingham, UK.Bristol Medical School, Population Health Sciences, University of Bristol, UK.School of Primary, Community and Social Care, Keele University, UK.Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, 5, Fu-Hsing Street, Taoyuan, 333, Taiwan.Division of Primary Care, School of Medicine, University of Nottingham, UK.Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, UK; Versus Arthritis Pain Centre, University of Nottingham, UK.Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, UK; Versus Arthritis Pain Centre, University of Nottingham, UK. Electronic address: weiya.zhang@nottingham.ac.uk.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32184134

Citation

Swain, S, et al. "Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings From the Clinical Practice Research Datalink (CPRD)." Osteoarthritis and Cartilage, vol. 28, no. 6, 2020, pp. 792-801.
Swain S, Sarmanova A, Mallen C, et al. Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis Cartilage. 2020;28(6):792-801.
Swain, S., Sarmanova, A., Mallen, C., Kuo, C. F., Coupland, C., Doherty, M., & Zhang, W. (2020). Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis and Cartilage, 28(6), 792-801. https://doi.org/10.1016/j.joca.2020.03.004
Swain S, et al. Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings From the Clinical Practice Research Datalink (CPRD). Osteoarthritis Cartilage. 2020;28(6):792-801. PubMed PMID: 32184134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). AU - Swain,S, AU - Sarmanova,A, AU - Mallen,C, AU - Kuo,C F, AU - Coupland,C, AU - Doherty,M, AU - Zhang,W, Y1 - 2020/03/14/ PY - 2019/09/26/received PY - 2020/02/27/revised PY - 2020/03/05/accepted PY - 2020/3/19/pubmed PY - 2021/7/20/medline PY - 2020/3/19/entrez KW - Burden KW - Incidence KW - Osteoarthritis KW - Prevalence KW - Trends KW - UK SP - 792 EP - 801 JF - Osteoarthritis and cartilage JO - Osteoarthritis Cartilage VL - 28 IS - 6 N2 - OBJECTIVE: This study aimed to explore the incidence and prevalence of OA in the UK in 2017 and their trends from 1997 to 2017 using a large nationally representative primary care database. DESIGN: The UK Clinical Practice Research Datalink (CPRD) comprising data on nearly 17.5 million patients was used for the study. The incidence and prevalence of general practitioner diagnosed OA over a 20 years period (1997-2017) were estimated and age-sex and length of data contribution standardized using the 2017 CPRD population structure. Cohort effects were examined through Age-period-cohort analysis. RESULTS: During 1997-2017, there were 494,716 incident OA cases aged ≥20 years. The standardised incidence of any OA in 2017 was 6.8 per 1000 person-years (95% CI 6.7 to 6.9) and prevalence was 10.7% (95% CI 10.7-10.8%). Both incidence and prevalence were higher in women than men. The incidence of any-OA decreased gradually in the past 20 years at an annual rate of -1.6% (95%CI -2.0 to -1.1%), and the reduction speeded up for people born after 1960. The prevalence of any-OA increased gradually at an annual rate of 1.4% (95% CI 1.3-1.6%). Although the prevalence was highest in Scotland and Northern Ireland, incidence was highest in the East Midlands. Both incidence and prevalence reported highest in the knee followed by hip, wrist/hand and ankle/foot. CONCLUSION: In the UK approximately one in 10 adults have symptomatic clinically diagnosed OA, the knee being the commonest. While prevalence has increased and become static after 2008, incidence is slowly declining. Further research is required to understand these changes. SN - 1522-9653 UR - https://www.unboundmedicine.com/medline/citation/32184134/Trends_in_incidence_and_prevalence_of_osteoarthritis_in_the_United_Kingdom:_findings_from_the_Clinical_Practice_Research_Datalink__CPRD__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1063-4584(20)30918-3 DB - PRIME DP - Unbound Medicine ER -