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Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals.
Nutrients. 2020 Mar 16; 12(3)N

Abstract

Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65-74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital® water-soluble CoQ10 syrup (the investigational product-IP); ubiquinol capsules (the comparative product-CP); and ubiquinone capsules (the standard product-SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (ΔAUC48) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3-4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9-3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone.

Authors+Show Affiliations

Nutrition Institute, Tržaška cesta 40, SI-1000 Ljubljana, Slovenia. Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, 1000 Ljubljana, Slovenia.Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, 41013 Seville, Spain.Department of Physiology, Anatomy and Cell Biology, Pablo de Olavide University, 41013 Seville, Spain.Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.Nutrition Institute, Tržaška cesta 40, SI-1000 Ljubljana, Slovenia.Nutrition Institute, Tržaška cesta 40, SI-1000 Ljubljana, Slovenia. VIST-Higher School of Applied Sciences, Gerbičeva cesta 51A, SI-1000 Ljubljana, Slovenia.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

32188111

Citation

Pravst, Igor, et al. "Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals." Nutrients, vol. 12, no. 3, 2020.
Pravst I, Rodríguez Aguilera JC, Cortes Rodriguez AB, et al. Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. Nutrients. 2020;12(3).
Pravst, I., Rodríguez Aguilera, J. C., Cortes Rodriguez, A. B., Jazbar, J., Locatelli, I., Hristov, H., & Žmitek, K. (2020). Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. Nutrients, 12(3). https://doi.org/10.3390/nu12030784
Pravst I, et al. Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. Nutrients. 2020 Mar 16;12(3) PubMed PMID: 32188111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals. AU - Pravst,Igor, AU - Rodríguez Aguilera,Juan Carlos, AU - Cortes Rodriguez,Ana Belen, AU - Jazbar,Janja, AU - Locatelli,Igor, AU - Hristov,Hristo, AU - Žmitek,Katja, Y1 - 2020/03/16/ PY - 2020/02/07/received PY - 2020/03/05/revised PY - 2020/03/11/accepted PY - 2020/3/20/entrez PY - 2020/3/20/pubmed PY - 2020/3/20/medline KW - CoQ10 KW - Q10Vital® KW - bioavailability KW - coenzyme Q10 KW - the elderly KW - ubiquinol KW - ubiquinone KW - water-soluble formulations JF - Nutrients JO - Nutrients VL - 12 IS - 3 N2 - Coenzyme Q10 (CoQ10) plays a central role in mitochondrial oxidative phosphorylation. Several studies have shown the beneficial effects of dietary CoQ10 supplementation, particularly in relation to cardiovascular health. CoQ10 biosynthesis decreases in the elderly, and consequently, the beneficial effects of dietary supplementation in this population are of greater significance. However, most pharmacokinetic studies have been conducted on younger populations. The aim of this study was to investigate the single-dose bioavailability of different formulations of CoQ10 in a healthy geriatric population. A randomized, three-period, crossover bioavailability study was conducted on 21 healthy older adults (aged 65-74). The treatment was a single dose with a one-week washout period. Three different formulations containing the equivalent of 100 mg of CoQ10 were used: Q10Vital® water-soluble CoQ10 syrup (the investigational product-IP); ubiquinol capsules (the comparative product-CP); and ubiquinone capsules (the standard product-SP). Ubiquinone/ubiquinol was followed in the plasma for 48 h. An analysis of the ratio of the area under the baseline-corrected concentration curve (ΔAUC48) for total CoQ10 and a comparison to SP yielded the following: The bioavailability of CoQ10 in the IP was 2.4-fold higher (95% CI: 1.3-4.5; p = 0.002), while the bioavailability of ubiquinol (CP) was not significantly increased (1.7-fold; 95% CI: 0.9-3.1, p = 0.129). No differences in the redox status of the absorbed coenzyme Q10 were observed between formulations, showing that CoQ10 appeared in the blood mostly as ubiquinol, even if consumed as ubiquinone. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32188111/Comparative_Bioavailability_of_Different_Coenzyme_Q10_Formulations_in_Healthy_Elderly_Individuals_ L2 - https://www.mdpi.com/resolver?pii=nu12030784 DB - PRIME DP - Unbound Medicine ER -