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Hemocoagulase agkistrodon can prevent bleeding and induce hypofibrinogenemia in hepatic disease cases .
Int J Clin Pharmacol Ther. 2020 Jun; 58(6):351-353.IJ

Abstract

Hemocoagulase is often used for hemostasis in patients with bleeding and hemorrhagic diseases, and to avoid or stanch bleeding after surgery. Herein, three patients with hepatic diseases suffering from hypofibrinogenemia were treated with hemocoagulase agkistrodon (HCA) in Peking University People's Hospital during September 2018. All the 3 patients were chronic hepatitis B patients: Patient 1 presented with hepatic carcinoma and chronic hepatitis B, and right hepatectomy was performed; patient 2 presented with chronic hepatitis B and gastrointestinal bleeding; patient 3 presented with chronic hepatitis B, acute liver failure with hematemesis, and was awaiting liver transplantation. All three patients were percutaneously injected with HCA to prevent late-onset bleeding. After HCA was discontinued, coagulation was restored to > 60 mg/dL on day 6, without injection of fibrinogen. HCA significantly reduced the need for fibrinogen in patients with hepatic diseases, and the level of fibrinogen should be carefully monitored in clinical applications.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32194023

Citation

Lu, Songsong, et al. "Hemocoagulase Agkistrodon Can Prevent Bleeding and Induce Hypofibrinogenemia in Hepatic Disease Cases ." International Journal of Clinical Pharmacology and Therapeutics, vol. 58, no. 6, 2020, pp. 351-353.
Lu S, Han M, Song Y, et al. Hemocoagulase agkistrodon can prevent bleeding and induce hypofibrinogenemia in hepatic disease cases . Int J Clin Pharmacol Ther. 2020;58(6):351-353.
Lu, S., Han, M., Song, Y., & Liu, C. (2020). Hemocoagulase agkistrodon can prevent bleeding and induce hypofibrinogenemia in hepatic disease cases . International Journal of Clinical Pharmacology and Therapeutics, 58(6), 351-353. https://doi.org/10.5414/CP203707
Lu S, et al. Hemocoagulase Agkistrodon Can Prevent Bleeding and Induce Hypofibrinogenemia in Hepatic Disease Cases. Int J Clin Pharmacol Ther. 2020;58(6):351-353. PubMed PMID: 32194023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hemocoagulase agkistrodon can prevent bleeding and induce hypofibrinogenemia in hepatic disease cases . AU - Lu,Songsong, AU - Han,Man, AU - Song,Ying, AU - Liu,Chen, PY - 2020/05/14/accepted PY - 2020/3/21/pubmed PY - 2020/3/21/medline PY - 2020/3/21/entrez SP - 351 EP - 353 JF - International journal of clinical pharmacology and therapeutics JO - Int J Clin Pharmacol Ther VL - 58 IS - 6 N2 - Hemocoagulase is often used for hemostasis in patients with bleeding and hemorrhagic diseases, and to avoid or stanch bleeding after surgery. Herein, three patients with hepatic diseases suffering from hypofibrinogenemia were treated with hemocoagulase agkistrodon (HCA) in Peking University People's Hospital during September 2018. All the 3 patients were chronic hepatitis B patients: Patient 1 presented with hepatic carcinoma and chronic hepatitis B, and right hepatectomy was performed; patient 2 presented with chronic hepatitis B and gastrointestinal bleeding; patient 3 presented with chronic hepatitis B, acute liver failure with hematemesis, and was awaiting liver transplantation. All three patients were percutaneously injected with HCA to prevent late-onset bleeding. After HCA was discontinued, coagulation was restored to > 60 mg/dL on day 6, without injection of fibrinogen. HCA significantly reduced the need for fibrinogen in patients with hepatic diseases, and the level of fibrinogen should be carefully monitored in clinical applications. SN - 0946-1965 UR - https://www.unboundmedicine.com/medline/citation/32194023/Hemocoagulase_agkistrodon_can_prevent_bleeding_and_induce_hypofibrinogenemia_in_hepatic_disease_cases_ L2 - https://www.dustri.com/nc/journals-in-english?artId=186301 DB - PRIME DP - Unbound Medicine ER -
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