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Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer.
Oncol Lett. 2020 Mar; 19(3):2375-2383.OL

Abstract

Patients with schistosomal colorectal cancer (CRC) and nonschistosomal CRC have different clinicopathological features, laboratory test results and survival rates. Long-term infection with schistosomiasis in patients with CRC may affect the pathogenesis and subsequently change the mechanisms of CRC in these patients, resulting in changes in the survival rates of patients with schistosomal and nonschistosomal CRC. In China, the most common type of schistosomiasis is S. japonicum. The present study aimed to investigate the clinicopathological features and prognostic factors of schistosomal and nonschistosomal CRC. A total of 253 patients with schistosomal CRC and 2,885 patients with nonschistosomal CRC were analyzed and their symptoms, clinicopathological features and laboratory test results were retrospectively evaluated. Patients with CRC in the present study underwent radical resection at The First Affiliated Yijishan Hospital of Wannan Medical College between January 2012 and December 2018. A total of 3,138 patients with CRC were enrolled, 253 of whom were patients with schistosomal CRC. Patients were followed-up to examine differences in the 5-year survival rates between patients with schistosomal and nonschistosomal CRC to determine whether schistosomiasis impacted the prognosis of CRC. There were significant differences in age, sex, fecal occult blood positive, pathological T stage, and CA19-9, WBC, RBC and PLT levels between patients with schistosomal CRC and nonschistosomal CRC. For residents in areas with higher levels of schistosomiasis infections, especially middle-aged and elderly males, serum tumor markers and digestive tract endoscopy should be regularly evaluated to detect the presence of digestive tract tumors as early as possible.

Authors+Show Affiliations

Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.Department of Pathology, Wannan Medical College, Wuhu, Anhui 241001, P.R. China.Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.Department of Infectious Diseases, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32194737

Citation

Wang, Zijian, et al. "Comparison of the Clinicopathological Features and Prognoses of Patients With Schistosomal and Nonschistosomal Colorectal Cancer." Oncology Letters, vol. 19, no. 3, 2020, pp. 2375-2383.
Wang Z, Du Z, Liu Y, et al. Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer. Oncol Lett. 2020;19(3):2375-2383.
Wang, Z., Du, Z., Liu, Y., Wang, W., Liang, M., Zhang, A., & Yang, J. (2020). Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer. Oncology Letters, 19(3), 2375-2383. https://doi.org/10.3892/ol.2020.11331
Wang Z, et al. Comparison of the Clinicopathological Features and Prognoses of Patients With Schistosomal and Nonschistosomal Colorectal Cancer. Oncol Lett. 2020;19(3):2375-2383. PubMed PMID: 32194737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the clinicopathological features and prognoses of patients with schistosomal and nonschistosomal colorectal cancer. AU - Wang,Zijian, AU - Du,Zhixiang, AU - Liu,Yinhua, AU - Wang,Wenjie, AU - Liang,Manman, AU - Zhang,Aiping, AU - Yang,Jianghua, Y1 - 2020/01/22/ PY - 2019/07/12/received PY - 2019/11/26/accepted PY - 2020/3/21/entrez PY - 2020/3/21/pubmed PY - 2020/3/21/medline KW - clinical characteristics KW - colorectal cancer KW - prognosis KW - schistosomal KW - survival rate SP - 2375 EP - 2383 JF - Oncology letters JO - Oncol Lett VL - 19 IS - 3 N2 - Patients with schistosomal colorectal cancer (CRC) and nonschistosomal CRC have different clinicopathological features, laboratory test results and survival rates. Long-term infection with schistosomiasis in patients with CRC may affect the pathogenesis and subsequently change the mechanisms of CRC in these patients, resulting in changes in the survival rates of patients with schistosomal and nonschistosomal CRC. In China, the most common type of schistosomiasis is S. japonicum. The present study aimed to investigate the clinicopathological features and prognostic factors of schistosomal and nonschistosomal CRC. A total of 253 patients with schistosomal CRC and 2,885 patients with nonschistosomal CRC were analyzed and their symptoms, clinicopathological features and laboratory test results were retrospectively evaluated. Patients with CRC in the present study underwent radical resection at The First Affiliated Yijishan Hospital of Wannan Medical College between January 2012 and December 2018. A total of 3,138 patients with CRC were enrolled, 253 of whom were patients with schistosomal CRC. Patients were followed-up to examine differences in the 5-year survival rates between patients with schistosomal and nonschistosomal CRC to determine whether schistosomiasis impacted the prognosis of CRC. There were significant differences in age, sex, fecal occult blood positive, pathological T stage, and CA19-9, WBC, RBC and PLT levels between patients with schistosomal CRC and nonschistosomal CRC. For residents in areas with higher levels of schistosomiasis infections, especially middle-aged and elderly males, serum tumor markers and digestive tract endoscopy should be regularly evaluated to detect the presence of digestive tract tumors as early as possible. SN - 1792-1074 UR - https://www.unboundmedicine.com/medline/citation/32194737/Comparison_of_the_clinicopathological_features_and_prognoses_of_patients_with_schistosomal_and_nonschistosomal_colorectal_cancer_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1792-1074&volume=19&issue=3&spage=2375&aulast=Wang DB - PRIME DP - Unbound Medicine ER -
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