Tags

Type your tag names separated by a space and hit enter

Post-artemisinin delayed hemolysis after oral therapy for P. falciparum infection.
IDCases. 2020; 20:e00741.I

Abstract

A documented side-effect of artemisinin therapy is post-artemisinin delayed hemolysis (PADH), primarily occurring after parenteral treatment for severe P. falciparum infections. PADH has been infrequently reported after oral therapy and is rarely severe enough to require hospitalization and blood transfusions. A 24 year old man was diagnosed with P. falciparum, prompting initiation of oral artemether-lumefantrine (AL). Further work-up demonstrated that he met WHO criteria for severe malaria infection on the basis of high parasitemia and his regimen was switched to intravenous quinidine and oral doxycycline. He was transitioned back to AL after 4 days and was discharged on hospital day six. Five days later, he was readmitted for hemolytic anemia. His peripheral blood was absent of malaria parasites and he was diagnosed with PADH, ultimately requiring multiple blood transfusions. Severe hemolytic anemia requiring blood transfusions after oral artemisinin therapy is rare and may be associated with higher parasite loads. This case demonstrates the importance of close reassessment and consideration of PADH in patients treated with oral therapies, particularly in the setting of severe malarial infections.

Authors+Show Affiliations

Madigan Army Medical Center Department of Medicine, 9040 Jackson Ave, Fort Lewis McChord, Washington, 98413, USA.Madigan Army Medical Center Department of Medicine, 9040 Jackson Ave, Fort Lewis McChord, Washington, 98413, USA.Madigan Army Medical Center Department of Medicine, 9040 Jackson Ave, Fort Lewis McChord, Washington, 98413, USA.Madigan Army Medical Center Department of Medicine, 9040 Jackson Ave, Fort Lewis McChord, Washington, 98413, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

32195118

Citation

Conlon, Christian C., et al. "Post-artemisinin Delayed Hemolysis After Oral Therapy for P. Falciparum Infection." IDCases, vol. 20, 2020, pp. e00741.
Conlon CC, Stein A, Colombo RE, et al. Post-artemisinin delayed hemolysis after oral therapy for P. falciparum infection. IDCases. 2020;20:e00741.
Conlon, C. C., Stein, A., Colombo, R. E., & Schofield, C. (2020). Post-artemisinin delayed hemolysis after oral therapy for P. falciparum infection. IDCases, 20, e00741. https://doi.org/10.1016/j.idcr.2020.e00741
Conlon CC, et al. Post-artemisinin Delayed Hemolysis After Oral Therapy for P. Falciparum Infection. IDCases. 2020;20:e00741. PubMed PMID: 32195118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-artemisinin delayed hemolysis after oral therapy for P. falciparum infection. AU - Conlon,Christian C, AU - Stein,Anna, AU - Colombo,Rhonda E, AU - Schofield,Christina, Y1 - 2020/03/03/ PY - 2020/02/25/received PY - 2020/03/02/revised PY - 2020/03/02/accepted PY - 2020/3/21/entrez PY - 2020/3/21/pubmed PY - 2020/3/21/medline KW - Artemether-lumefantrine KW - Hemolytic anemia KW - Oral artemisinin therapy KW - P. falciparum infection KW - Post-artemisinin delayed hemolysis KW - Severe malaria infection SP - e00741 EP - e00741 JF - IDCases JO - IDCases VL - 20 N2 - A documented side-effect of artemisinin therapy is post-artemisinin delayed hemolysis (PADH), primarily occurring after parenteral treatment for severe P. falciparum infections. PADH has been infrequently reported after oral therapy and is rarely severe enough to require hospitalization and blood transfusions. A 24 year old man was diagnosed with P. falciparum, prompting initiation of oral artemether-lumefantrine (AL). Further work-up demonstrated that he met WHO criteria for severe malaria infection on the basis of high parasitemia and his regimen was switched to intravenous quinidine and oral doxycycline. He was transitioned back to AL after 4 days and was discharged on hospital day six. Five days later, he was readmitted for hemolytic anemia. His peripheral blood was absent of malaria parasites and he was diagnosed with PADH, ultimately requiring multiple blood transfusions. Severe hemolytic anemia requiring blood transfusions after oral artemisinin therapy is rare and may be associated with higher parasite loads. This case demonstrates the importance of close reassessment and consideration of PADH in patients treated with oral therapies, particularly in the setting of severe malarial infections. SN - 2214-2509 UR - https://www.unboundmedicine.com/medline/citation/32195118/Post-artemisinin_delayed_hemolysis_after_oral_therapy_for_P._falciparum_infection L2 - https://linkinghub.elsevier.com/retrieve/pii/S2214-2509(20)30049-4 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.