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Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel.
Int J Pharm Compd. 2020 Mar-Apr; 24(2):168-175.IJ

Abstract

The objective of this project was to study the percutaneous absorption of lorazepam, diphenhydramine hydrochloride, and haloperidol from a topical Pluronic lecithin organogel, also known as ABH gel, across the porcine ear skin and verify its suitability for topical application. ABH gel was prepared using lecithin in isopropyl palmitate solution (1:1) as an oil phase and 20% w/v Poloxamer 407 solution as an aqueous phase. The gel was characterized for pH, viscosity, drug content, and thermal behavior. A robust high-performance liquid chromatography method was developed and validated for simultaneous analysis of lorazepam, diphenhydramine hydrochloride, and haloperidol. The percutaneous absorption of lorazepam, diphenhydramine hydrochloride, and haloperidol from ABH gel was carried out using Franz cells across the Strat-M membrane and pig ear skin. The pH of ABH gel was found to be 5.66 ± 0.13. The retention time of diphenhydramine hydrochloride, haloperidol, and lorazepam was found to be 5.2 minutes, 7.8 minutes, and 18.9 minutes, respectively. The ABH gel was found to be stable for up to 30 days. Theoretical steady state plasma concentrations (CSS) of diphenhydramine hydrochloride, haloperidol, and lorazepam calculated from flux values were found to be 1.6 ng/mL, 0.13 ng/mL, and 2.30 ng/mL, respectively. The theoretical CSS of diphenhydramine hydrochloride, haloperidol, and lorazepam were much lower than required therapeutic concentrations for antiemetic activity to relieve chemotherapy-induced nausea and vomiting. From the percutaneous absorption data, it was evident that ABH gel failed to achieve required systemic levels of lorazepam, diphenhydramine hydrochloride, and haloperidol following topical application.

Authors+Show Affiliations

College of Pharmacy and Pharmaceutical Sciences, The University of Toledo Health Science Campus, Toledo, Ohio.College of Pharmacy and Pharmaceutical Sciences, The University of Toledo Health Science Campus, Toledo, Ohio.College of Pharmacy and Pharmaceutical Sciences, The University of Toledo Health Science Campus, Toledo, Ohio. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.School of Pharmacy, The University of Texas at El Paso, El Paso, Texas.College of Pharmacy, The University of Findlay, Findlay, Ohio.College of Pharmacy, The University of Findlay, Findlay, Ohio.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32196480

Citation

Dahal, Amit, et al. "Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol From ABH Gel." International Journal of Pharmaceutical Compounding, vol. 24, no. 2, 2020, pp. 168-175.
Dahal A, Neupane R, Boddu SH, et al. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. Int J Pharm Compd. 2020;24(2):168-175.
Dahal, A., Neupane, R., Boddu, S. H., Renukuntla, J., Khupse, R., & Dudley, R. (2020). Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. International Journal of Pharmaceutical Compounding, 24(2), 168-175.
Dahal A, et al. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol From ABH Gel. Int J Pharm Compd. 2020 Mar-Apr;24(2):168-175. PubMed PMID: 32196480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. AU - Dahal,Amit, AU - Neupane,Rabin, AU - Boddu,Sai Hs, AU - Renukuntla,Jwala, AU - Khupse,Rahul, AU - Dudley,Richard, PY - 2020/3/21/entrez PY - 2020/3/21/pubmed PY - 2020/6/25/medline SP - 168 EP - 175 JF - International journal of pharmaceutical compounding JO - Int J Pharm Compd VL - 24 IS - 2 N2 - The objective of this project was to study the percutaneous absorption of lorazepam, diphenhydramine hydrochloride, and haloperidol from a topical Pluronic lecithin organogel, also known as ABH gel, across the porcine ear skin and verify its suitability for topical application. ABH gel was prepared using lecithin in isopropyl palmitate solution (1:1) as an oil phase and 20% w/v Poloxamer 407 solution as an aqueous phase. The gel was characterized for pH, viscosity, drug content, and thermal behavior. A robust high-performance liquid chromatography method was developed and validated for simultaneous analysis of lorazepam, diphenhydramine hydrochloride, and haloperidol. The percutaneous absorption of lorazepam, diphenhydramine hydrochloride, and haloperidol from ABH gel was carried out using Franz cells across the Strat-M membrane and pig ear skin. The pH of ABH gel was found to be 5.66 ± 0.13. The retention time of diphenhydramine hydrochloride, haloperidol, and lorazepam was found to be 5.2 minutes, 7.8 minutes, and 18.9 minutes, respectively. The ABH gel was found to be stable for up to 30 days. Theoretical steady state plasma concentrations (CSS) of diphenhydramine hydrochloride, haloperidol, and lorazepam calculated from flux values were found to be 1.6 ng/mL, 0.13 ng/mL, and 2.30 ng/mL, respectively. The theoretical CSS of diphenhydramine hydrochloride, haloperidol, and lorazepam were much lower than required therapeutic concentrations for antiemetic activity to relieve chemotherapy-induced nausea and vomiting. From the percutaneous absorption data, it was evident that ABH gel failed to achieve required systemic levels of lorazepam, diphenhydramine hydrochloride, and haloperidol following topical application. SN - 1092-4221 UR - https://www.unboundmedicine.com/medline/citation/32196480/Percutaneous_Absorption_of_Lorazepam,_Diphenhydramine_Hydrochloride,_and_Haloperidol_from_ABH_Gel L2 - https://ijpc.com/Abstracts/FindByVolPage.cfm?Vol=24&Page=168 DB - PRIME DP - Unbound Medicine ER -