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Prenatal bisphenol A exposure, fetal thyroid hormones and neurobehavioral development in children at 2 and 4 years: A prospective cohort study.
Sci Total Environ. 2020 Jun 20; 722:137887.ST

Abstract

Findings about the association between prenatal Bisphenol A (BPA) exposure and neurobehavioral development in children are still inconsistent. In addition, whether fetal thyroid hormones (THs) mediate the reported association remains unclear. The present study aimed to examine the association between prenatal BPA exposure and risks of child behavioral problems at 2 and 4 years of age and whether the association could be explained by alteration of fetal THs as measured in cord plasma. Using the Shanghai-Minhang Birth Cohort Study (S-MBCS), BPA concentration was measured in maternal urine samples collected at 12-16 weeks of gestation. Children's neurobehavioral development was assessed using the Child Behavior Checklist/1.5-5 (CBCL), at 2 and 4 years of age. Using generalized estimating equation (GEE) models, 745 mother-pairs were included to examine associations of BPA with CBCL scores, Using multiple linear regression models, 348 mother-pairs were included to evaluate the association between maternal BPA and THs in cord plasma. A mediation analysis was conducted to explore the potential mediating role of THs. After adjusting for potential confounders, prenatal BPA level was associated with increased risks of Emotionally Reactive problem, Anxious/Depressed problem, having Somatic Complaints, exhibiting Aggressive Behavior, and Internalizing and Externalizing Problems: compared to the lowest tertile, the risks in the highest tertile and middle tertile, ranged between 1.55-fold (95% CI: 1.09, 2.21) and 2.59-fold (95% CI: 1.52, 4.42). The association was more pronounced among boys. None of the associations reached statistical significance among girls. An inverse association between prenatal BPA and fetal TH level was also observed. However, the observed neurotoxic effects of prenatal BPA exposure did not appear to be mediated by THs levels. The current findings suggest that prenatal exposure to BPA may disrupt fetal THs levels and may induce long-lasting behavioral alterations, especially in boys.

Authors+Show Affiliations

NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China; Department of Chronic Infectious Disease Control and Prevention, Putuo District Center for Disease Control and Prevention, Shanghai, China.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China; Department of Global Public Health, Karolinska Institutet, Sweden.Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, CA, USA.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China; Management Office for National Screening Project of NCHD, Children's Hospital of Fudan University, Shanghai, China.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China.NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China. Electronic address: lianghong@sippr.org.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32197165

Citation

Li, Fen, et al. "Prenatal Bisphenol a Exposure, Fetal Thyroid Hormones and Neurobehavioral Development in Children at 2 and 4 years: a Prospective Cohort Study." The Science of the Total Environment, vol. 722, 2020, p. 137887.
Li F, Yang F, Li DK, et al. Prenatal bisphenol A exposure, fetal thyroid hormones and neurobehavioral development in children at 2 and 4 years: A prospective cohort study. Sci Total Environ. 2020;722:137887.
Li, F., Yang, F., Li, D. K., Tian, Y., Miao, M., Zhang, Y., Ji, H., Yuan, W., & Liang, H. (2020). Prenatal bisphenol A exposure, fetal thyroid hormones and neurobehavioral development in children at 2 and 4 years: A prospective cohort study. The Science of the Total Environment, 722, 137887. https://doi.org/10.1016/j.scitotenv.2020.137887
Li F, et al. Prenatal Bisphenol a Exposure, Fetal Thyroid Hormones and Neurobehavioral Development in Children at 2 and 4 years: a Prospective Cohort Study. Sci Total Environ. 2020 Jun 20;722:137887. PubMed PMID: 32197165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal bisphenol A exposure, fetal thyroid hormones and neurobehavioral development in children at 2 and 4 years: A prospective cohort study. AU - Li,Fen, AU - Yang,Fen, AU - Li,De-Kun, AU - Tian,Youping, AU - Miao,Maohua, AU - Zhang,Yan, AU - Ji,Honglei, AU - Yuan,Wei, AU - Liang,Hong, Y1 - 2020/03/12/ PY - 2019/11/13/received PY - 2020/02/29/revised PY - 2020/03/10/accepted PY - 2020/3/21/pubmed PY - 2020/6/26/medline PY - 2020/3/21/entrez KW - Bisphenol A KW - Neurobehavioral development KW - Prenatal exposure KW - Thyroid hormones SP - 137887 EP - 137887 JF - The Science of the total environment JO - Sci. Total Environ. VL - 722 N2 - Findings about the association between prenatal Bisphenol A (BPA) exposure and neurobehavioral development in children are still inconsistent. In addition, whether fetal thyroid hormones (THs) mediate the reported association remains unclear. The present study aimed to examine the association between prenatal BPA exposure and risks of child behavioral problems at 2 and 4 years of age and whether the association could be explained by alteration of fetal THs as measured in cord plasma. Using the Shanghai-Minhang Birth Cohort Study (S-MBCS), BPA concentration was measured in maternal urine samples collected at 12-16 weeks of gestation. Children's neurobehavioral development was assessed using the Child Behavior Checklist/1.5-5 (CBCL), at 2 and 4 years of age. Using generalized estimating equation (GEE) models, 745 mother-pairs were included to examine associations of BPA with CBCL scores, Using multiple linear regression models, 348 mother-pairs were included to evaluate the association between maternal BPA and THs in cord plasma. A mediation analysis was conducted to explore the potential mediating role of THs. After adjusting for potential confounders, prenatal BPA level was associated with increased risks of Emotionally Reactive problem, Anxious/Depressed problem, having Somatic Complaints, exhibiting Aggressive Behavior, and Internalizing and Externalizing Problems: compared to the lowest tertile, the risks in the highest tertile and middle tertile, ranged between 1.55-fold (95% CI: 1.09, 2.21) and 2.59-fold (95% CI: 1.52, 4.42). The association was more pronounced among boys. None of the associations reached statistical significance among girls. An inverse association between prenatal BPA and fetal TH level was also observed. However, the observed neurotoxic effects of prenatal BPA exposure did not appear to be mediated by THs levels. The current findings suggest that prenatal exposure to BPA may disrupt fetal THs levels and may induce long-lasting behavioral alterations, especially in boys. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/32197165/Prenatal_bisphenol_A_exposure_fetal_thyroid_hormones_and_neurobehavioral_development_in_children_at_2_and_4 years:_A_prospective_cohort_study_ DB - PRIME DP - Unbound Medicine ER -