TY - JOUR T1 - Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity. AU - Li,Yuchen, AU - Aiello,Gilda, AU - Bollati,Carlotta, AU - Bartolomei,Martina, AU - Arnoldi,Anna, AU - Lammi,Carmen, Y1 - 2020/03/18/ PY - 2020/02/27/received PY - 2020/03/12/revised PY - 2020/03/16/accepted PY - 2020/3/22/entrez PY - 2020/3/22/pubmed PY - 2021/1/7/medline KW - C-Phycocyanin KW - DPP-IV KW - LC-MS/MS KW - Spirulina platensis KW - allophycocyanin KW - bioactive peptides JF - Nutrients JO - Nutrients VL - 12 IS - 3 N2 - Arthrospira platensis (spirulina) is a cyanobacterium, which contains mainly two phycobiliproteins (PBP), i.e., C-phycocyanin (C-PC) and allophycocyanin (APC). In this study, PBP were hydrolyzed using trypsin, and the composition of the hydrolysate was characterized by HPLC-ESI-MS/MS. Furthermore, the potential anti-diabetic activity was assessed by using either biochemical or cellular techniques. Findings suggest that PBP peptides inhibit DPP-IV activity in vitro with a dose-response trend and an IC50 value falling in the range between 0.5 and 1.0 mg/mL. A lower inhibition of the DPP-IV activity expressed by Caco-2 cells was observed, which was explained by a secondary metabolic degradation exerted by the same cells. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32197331/Phycobiliproteins_from_Arthrospira_Platensis__Spirulina_:_A_New_Source_of_Peptides_with_Dipeptidyl_Peptidase_IV_Inhibitory_Activity_ DB - PRIME DP - Unbound Medicine ER -