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A case of Graves' disease associated with an autonomously functioning thyroid nodule (AFTN) (Marine-Lenhalt syndrome) which spontaneously became a cold nodule.
Endocrinol Jpn. 1988 Oct; 35(5):753-8.EJ

Abstract

We report a 31-year-old female with Graves' disease associated with an autonomously functioning thyroid nodule (AFTN) (Marine-Lenhalt syndrome) in which the AFTN spontaneously became a cold nodule. Initially the patient was thyrotoxic and had diffuse goiter with an elevated radioiodine uptake. She became euthyroid following six months of antithyroid drug therapy, and in addition to diffuse goiter, the solitary hot nodule was palpable in the left lobe. Fourteen months later, hyperthyroidism recurred and the thyroid scan revealed diffuse radioiodine uptake with a cold area in the nodular region. The resected nodule showed extensive degeneration and the histological diagnosis was follicular adenoma with Graves' disease. We discussed the significance of recognizing the syndrome and also compared the frequency of spontaneous degeneration in AFTN and in solitary cold nodules.

Authors+Show Affiliations

Department of Internal Medicine, Hokkaido Central Hospital for Social Health Insurance, Sapporo, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3220052

Citation

Konno, N, et al. "A Case of Graves' Disease Associated With an Autonomously Functioning Thyroid Nodule (AFTN) (Marine-Lenhalt Syndrome) Which Spontaneously Became a Cold Nodule." Endocrinologia Japonica, vol. 35, no. 5, 1988, pp. 753-8.
Konno N, Hirokawa J, Abe S. A case of Graves' disease associated with an autonomously functioning thyroid nodule (AFTN) (Marine-Lenhalt syndrome) which spontaneously became a cold nodule. Endocrinol Jpn. 1988;35(5):753-8.
Konno, N., Hirokawa, J., & Abe, S. (1988). A case of Graves' disease associated with an autonomously functioning thyroid nodule (AFTN) (Marine-Lenhalt syndrome) which spontaneously became a cold nodule. Endocrinologia Japonica, 35(5), 753-8.
Konno N, Hirokawa J, Abe S. A Case of Graves' Disease Associated With an Autonomously Functioning Thyroid Nodule (AFTN) (Marine-Lenhalt Syndrome) Which Spontaneously Became a Cold Nodule. Endocrinol Jpn. 1988;35(5):753-8. PubMed PMID: 3220052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of Graves' disease associated with an autonomously functioning thyroid nodule (AFTN) (Marine-Lenhalt syndrome) which spontaneously became a cold nodule. AU - Konno,N, AU - Hirokawa,J, AU - Abe,S, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 753 EP - 8 JF - Endocrinologia japonica JO - Endocrinol. Jpn. VL - 35 IS - 5 N2 - We report a 31-year-old female with Graves' disease associated with an autonomously functioning thyroid nodule (AFTN) (Marine-Lenhalt syndrome) in which the AFTN spontaneously became a cold nodule. Initially the patient was thyrotoxic and had diffuse goiter with an elevated radioiodine uptake. She became euthyroid following six months of antithyroid drug therapy, and in addition to diffuse goiter, the solitary hot nodule was palpable in the left lobe. Fourteen months later, hyperthyroidism recurred and the thyroid scan revealed diffuse radioiodine uptake with a cold area in the nodular region. The resected nodule showed extensive degeneration and the histological diagnosis was follicular adenoma with Graves' disease. We discussed the significance of recognizing the syndrome and also compared the frequency of spontaneous degeneration in AFTN and in solitary cold nodules. SN - 0013-7219 UR - https://www.unboundmedicine.com/medline/citation/3220052/A_case_of_Graves'_disease_associated_with_an_autonomously_functioning_thyroid_nodule__AFTN___Marine_Lenhalt_syndrome__which_spontaneously_became_a_cold_nodule_ L2 - https://joi.jlc.jst.go.jp/JST.Journalarchive/endocrj1954/35.753?from=PubMed DB - PRIME DP - Unbound Medicine ER -
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