Tags

Type your tag names separated by a space and hit enter

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection.
Biochem Biophys Res Commun. 2020 05 21; 526(1):165-169.BB

Abstract

SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection.

Authors+Show Affiliations

Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China.Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong, China.Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, 250200, Shandong, China.Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250062, Shandong, China. Electronic address: armzhang@hotmail.com.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32201080

Citation

Luan, Junwen, et al. "Spike Protein Recognition of Mammalian ACE2 Predicts the Host Range and an Optimized ACE2 for SARS-CoV-2 Infection." Biochemical and Biophysical Research Communications, vol. 526, no. 1, 2020, pp. 165-169.
Luan J, Lu Y, Jin X, et al. Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection. Biochem Biophys Res Commun. 2020;526(1):165-169.
Luan, J., Lu, Y., Jin, X., & Zhang, L. (2020). Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection. Biochemical and Biophysical Research Communications, 526(1), 165-169. https://doi.org/10.1016/j.bbrc.2020.03.047
Luan J, et al. Spike Protein Recognition of Mammalian ACE2 Predicts the Host Range and an Optimized ACE2 for SARS-CoV-2 Infection. Biochem Biophys Res Commun. 2020 05 21;526(1):165-169. PubMed PMID: 32201080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection. AU - Luan,Junwen, AU - Lu,Yue, AU - Jin,Xiaolu, AU - Zhang,Leiliang, Y1 - 2020/03/19/ PY - 2020/02/27/received PY - 2020/03/09/accepted PY - 2020/3/24/pubmed PY - 2020/4/29/medline PY - 2020/3/24/entrez KW - ACE2 KW - Host range KW - SARS-CoV-2 KW - Spike protein KW - Structure SP - 165 EP - 169 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 526 IS - 1 N2 - SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/32201080/Spike_protein_recognition_of_mammalian_ACE2_predicts_the_host_range_and_an_optimized_ACE2_for_SARS_CoV_2_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(20)30526-X DB - PRIME DP - Unbound Medicine ER -