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Advanced case of PKDL due to delayed treatment: A rare case report.
PLoS Negl Trop Dis. 2020 03; 14(3):e0008052.PN

Abstract

Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Leishmania donovani has been reported and is one of the major concerns in the treatment of PKDL. Here, we report a highly ulcerated PKDL case that was successfully cured after miltefosine treatment.

Authors+Show Affiliations

Department of Epidemiology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Pathology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Clinical Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Biostatistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Immunology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.Department of Molecular Biology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna, India.

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32203500

Citation

Topno, Roshan Kamal, et al. "Advanced Case of PKDL Due to Delayed Treatment: a Rare Case Report." PLoS Neglected Tropical Diseases, vol. 14, no. 3, 2020, pp. e0008052.
Topno RK, Rabi Das VN, Kumar M, et al. Advanced case of PKDL due to delayed treatment: A rare case report. PLoS Negl Trop Dis. 2020;14(3):e0008052.
Topno, R. K., Rabi Das, V. N., Kumar, M., Madhukar, M., Pandey, K., Verma, N., Agrawal, K., Lal, C. S., Siddiqui, N. A., Bimal, S., & Das, P. (2020). Advanced case of PKDL due to delayed treatment: A rare case report. PLoS Neglected Tropical Diseases, 14(3), e0008052. https://doi.org/10.1371/journal.pntd.0008052
Topno RK, et al. Advanced Case of PKDL Due to Delayed Treatment: a Rare Case Report. PLoS Negl Trop Dis. 2020;14(3):e0008052. PubMed PMID: 32203500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advanced case of PKDL due to delayed treatment: A rare case report. AU - Topno,Roshan Kamal, AU - Rabi Das,Vidya Nand, AU - Kumar,Maneesh, AU - Madhukar,Major, AU - Pandey,Krishna, AU - Verma,Neena, AU - Agrawal,Kanhaiya, AU - Lal,Chandra Shekhar, AU - Siddiqui,Niyamat Ali, AU - Bimal,Sanjiva, AU - Das,Pradeep, Y1 - 2020/03/23/ PY - 2020/3/24/entrez PY - 2020/3/24/pubmed PY - 2020/5/15/medline SP - e0008052 EP - e0008052 JF - PLoS neglected tropical diseases JO - PLoS Negl Trop Dis VL - 14 IS - 3 N2 - Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Leishmania donovani has been reported and is one of the major concerns in the treatment of PKDL. Here, we report a highly ulcerated PKDL case that was successfully cured after miltefosine treatment. SN - 1935-2735 UR - https://www.unboundmedicine.com/medline/citation/32203500/Advanced_case_of_PKDL_due_to_delayed_treatment:_A_rare_case_report_ L2 - https://dx.plos.org/10.1371/journal.pntd.0008052 DB - PRIME DP - Unbound Medicine ER -