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Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats.
Nutrients. 2020 Mar 19; 12(3)N

Abstract

Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses of FL (50, 100, and 200 mg/kg) or ranitidine (positive control, 30 mg/kg) via oral gavage daily for 14 days. One hour after the last oral administration of FL, the EtOH/HCl mixture was orally intubated to induce gastric damage. Oral administration of FL significantly alleviated the gastric lesions. Moreover, FL also elevated the amounts of nitric oxide and the antioxidant enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach. To verify the gastric mucosal defense mechanism, inflammation-related genes were measured. Our results revealed that FL effectively inhibited gastric mucosal damage via downregulation of the nuclear factor-kappaB (NF-κB) response in the stomach. The administration of FL significantly lowered the gastric mRNA expression of inflammation-related genes, including NF-κb1, tumor necrosis factor-α, interferon γ, and prostaglandin-endoperoxide synthase 2, compared with the gastric ulcer control group. In addition, the NF-κB signaling pathway-related protein markers inhibitor of κB (IκB)-α, IκB kinase, and NF-κB were significantly reduced in the FL groups. Taken together, these data suggest that FL administration may have potential as an alternative treatment for gastric ulcers due to its antioxidant and anti-inflammatory effects and its ability to promote the recovery of gastric mucosa.

Authors+Show Affiliations

Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Korea.Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Korea. Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Korea.Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Korea.Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Korea. Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32204312

Citation

Yoo, Jeong-Hyun, et al. "Gastroprotective Effects of Fermented Lotus Root Against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats." Nutrients, vol. 12, no. 3, 2020.
Yoo JH, Park EJ, Kim SH, et al. Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. Nutrients. 2020;12(3).
Yoo, J. H., Park, E. J., Kim, S. H., & Lee, H. J. (2020). Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. Nutrients, 12(3). https://doi.org/10.3390/nu12030808
Yoo JH, et al. Gastroprotective Effects of Fermented Lotus Root Against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. Nutrients. 2020 Mar 19;12(3) PubMed PMID: 32204312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective Effects of Fermented Lotus Root against Ethanol/HCl-Induced Gastric Mucosal Acute Toxicity in Rats. AU - Yoo,Jeong-Hyun, AU - Park,Eun-Jung, AU - Kim,So Hyeun, AU - Lee,Hae-Jeung, Y1 - 2020/03/19/ PY - 2020/02/21/received PY - 2020/03/16/revised PY - 2020/03/17/accepted PY - 2020/3/25/entrez PY - 2020/3/25/pubmed PY - 2020/12/15/medline KW - anti-inflammatory effect KW - antioxidant effect KW - fermented lotus root KW - gastric ulcer KW - gastroprotective effect JF - Nutrients JO - Nutrients VL - 12 IS - 3 N2 - Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses of FL (50, 100, and 200 mg/kg) or ranitidine (positive control, 30 mg/kg) via oral gavage daily for 14 days. One hour after the last oral administration of FL, the EtOH/HCl mixture was orally intubated to induce gastric damage. Oral administration of FL significantly alleviated the gastric lesions. Moreover, FL also elevated the amounts of nitric oxide and the antioxidant enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach. To verify the gastric mucosal defense mechanism, inflammation-related genes were measured. Our results revealed that FL effectively inhibited gastric mucosal damage via downregulation of the nuclear factor-kappaB (NF-κB) response in the stomach. The administration of FL significantly lowered the gastric mRNA expression of inflammation-related genes, including NF-κb1, tumor necrosis factor-α, interferon γ, and prostaglandin-endoperoxide synthase 2, compared with the gastric ulcer control group. In addition, the NF-κB signaling pathway-related protein markers inhibitor of κB (IκB)-α, IκB kinase, and NF-κB were significantly reduced in the FL groups. Taken together, these data suggest that FL administration may have potential as an alternative treatment for gastric ulcers due to its antioxidant and anti-inflammatory effects and its ability to promote the recovery of gastric mucosa. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32204312/Gastroprotective_Effects_of_Fermented_Lotus_Root_against_Ethanol/HCl_Induced_Gastric_Mucosal_Acute_Toxicity_in_Rats_ L2 - https://www.mdpi.com/resolver?pii=nu12030808 DB - PRIME DP - Unbound Medicine ER -