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Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines.
Recent Pat Drug Deliv Formul. 2020 Mar 24 [Online ahead of print]RP

Abstract

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve/disintegrate quickly leading to fast distribution of active ingredient at site of administration thereby provides ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. Objective of this review is to explore the application of various FDDFs to deliver extracts, herbal powders, natural active compounds and nutraceuticals. Scholarly literature from Pubmed, google scholar and directory of open access journals was retrieved. Patent search for US patent database, WIPO's Patentscope, Espacenet and google patents was performed. Collected literature was screened and only such researches/inventions involving use of FDDFs for delivery of herbal actives and natural active compounds are reported. With time, the use of FDDFs in alternative systems has significantly increased. Homeopathic system and traditional Chinese medicine have embraced FDDFs for delivery of active compounds. Most of the patents in this area are originating from China or by the Chinese innovators. In Europe and US, FDDFs have been extensively studied for delivery of natural active compounds. It was fascinating to know that some new dosage forms and new routes of delivering active compounds are also making their way to the family of FDDFs. Dose of active compound, size of dosage forms. Standardization of extracts, polyherbal mixtures, stability of active compounds, safety, efficacy and pharmacokinetics are challenging issues for developing FDDF herbal formulations or phytopharmaceuticals.

Authors+Show Affiliations

Department of Pharmacognosy, School of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Balawala . India.Department of Pharmaceutics, Sachdeva College of Pharmacy, Chandigarh-Ludhiana National Highway . India.Department of Pharmaceutics, School of Pharmaceutical Sciences & Technology, Sardar Bhagwan Singh University, Balawala . India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32208129

Citation

Singh, Anupama, et al. "Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines." Recent Patents On Drug Delivery & Formulation, 2020.
Singh A, Kharb V, Saharan VA. Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines. Recent Pat Drug Deliv Formul. 2020.
Singh, A., Kharb, V., & Saharan, V. A. (2020). Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines. Recent Patents On Drug Delivery & Formulation. https://doi.org/10.2174/1872211314666200324174703
Singh A, Kharb V, Saharan VA. Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines. Recent Pat Drug Deliv Formul. 2020 Mar 24; PubMed PMID: 32208129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines. AU - Singh,Anupama, AU - Kharb,Vandana, AU - Saharan,Vikas Anand, Y1 - 2020/03/24/ PY - 2019/10/08/received PY - 2020/02/11/revised PY - 2020/02/19/accepted PY - 2020/3/26/entrez PY - 2020/3/26/pubmed PY - 2020/3/26/medline KW - Ayurvedic KW - Orodispersible KW - extract KW - fibers KW - films KW - herbal KW - homeopathy KW - mats KW - nutraceuticals KW - orally disintegrating KW - pellets KW - phytopharmaceuticals KW - tablets KW - traditional Chinese medicine JF - Recent patents on drug delivery & formulation JO - Recent Pat Drug Deliv Formul N2 - Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve/disintegrate quickly leading to fast distribution of active ingredient at site of administration thereby provides ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. Objective of this review is to explore the application of various FDDFs to deliver extracts, herbal powders, natural active compounds and nutraceuticals. Scholarly literature from Pubmed, google scholar and directory of open access journals was retrieved. Patent search for US patent database, WIPO's Patentscope, Espacenet and google patents was performed. Collected literature was screened and only such researches/inventions involving use of FDDFs for delivery of herbal actives and natural active compounds are reported. With time, the use of FDDFs in alternative systems has significantly increased. Homeopathic system and traditional Chinese medicine have embraced FDDFs for delivery of active compounds. Most of the patents in this area are originating from China or by the Chinese innovators. In Europe and US, FDDFs have been extensively studied for delivery of natural active compounds. It was fascinating to know that some new dosage forms and new routes of delivering active compounds are also making their way to the family of FDDFs. Dose of active compound, size of dosage forms. Standardization of extracts, polyherbal mixtures, stability of active compounds, safety, efficacy and pharmacokinetics are challenging issues for developing FDDF herbal formulations or phytopharmaceuticals. SN - 2212-4039 UR - https://www.unboundmedicine.com/medline/citation/32208129/Fast_Dissolving/Disintegrating_Dosage_Forms_of_Natural_Active_Compounds_and_Alternative_Medicines L2 - http://www.eurekaselect.com/180489/article DB - PRIME DP - Unbound Medicine ER -
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