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Solubilization of preformed immune complexes in sera of patients with type 1 and type 2 lepra reactions.
Int J Lepr Other Mycobact Dis. 1988 Dec; 56(4):559-65.IJ

Abstract

Serum complement activity in leprosy patients has been studied using solubilization of preformed immune complexes as an index. The solubilization capacity of sera from lepromatous patients with or without erythema nodosum leprosum (ENL) as well as from type 1 reactional patients was found markedly reduced as compared to controls. Solubilization did not improve at all in the ENL patients after remission of the reaction phase. The addition of fresh normal sera failed to bring about any significant restoration of solubilizing capacity of the deficient sera. Mycobacterium leprae sonicate significantly reduced the solubilization capacity. Our results suggest that circulating mycobacterial breakdown products possibly interfered with the capacity of the ENL patients' sera to solubilize immune complexes.

Authors+Show Affiliations

Department of Biochemistry, University College of Medical Sciences, Shahdara, Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3221112

Citation

Chakrabarty, A K., et al. "Solubilization of Preformed Immune Complexes in Sera of Patients With Type 1 and Type 2 Lepra Reactions." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 56, no. 4, 1988, pp. 559-65.
Chakrabarty AK, Kashyap A, Sehgal VN, et al. Solubilization of preformed immune complexes in sera of patients with type 1 and type 2 lepra reactions. Int J Lepr Other Mycobact Dis. 1988;56(4):559-65.
Chakrabarty, A. K., Kashyap, A., Sehgal, V. N., & Saha, K. (1988). Solubilization of preformed immune complexes in sera of patients with type 1 and type 2 lepra reactions. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 56(4), 559-65.
Chakrabarty AK, et al. Solubilization of Preformed Immune Complexes in Sera of Patients With Type 1 and Type 2 Lepra Reactions. Int J Lepr Other Mycobact Dis. 1988;56(4):559-65. PubMed PMID: 3221112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solubilization of preformed immune complexes in sera of patients with type 1 and type 2 lepra reactions. AU - Chakrabarty,A K, AU - Kashyap,A, AU - Sehgal,V N, AU - Saha,K, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 559 EP - 65 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 56 IS - 4 N2 - Serum complement activity in leprosy patients has been studied using solubilization of preformed immune complexes as an index. The solubilization capacity of sera from lepromatous patients with or without erythema nodosum leprosum (ENL) as well as from type 1 reactional patients was found markedly reduced as compared to controls. Solubilization did not improve at all in the ENL patients after remission of the reaction phase. The addition of fresh normal sera failed to bring about any significant restoration of solubilizing capacity of the deficient sera. Mycobacterium leprae sonicate significantly reduced the solubilization capacity. Our results suggest that circulating mycobacterial breakdown products possibly interfered with the capacity of the ENL patients' sera to solubilize immune complexes. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/3221112/Solubilization_of_preformed_immune_complexes_in_sera_of_patients_with_type_1_and_type_2_lepra_reactions_ DB - PRIME DP - Unbound Medicine ER -