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Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin-Beck disease.
BMC Musculoskelet Disord. 2020 Mar 25; 21(1):188.BM

Abstract

BACKGROUND

Several questionnaires have been used to assess the health status of patients with Kashin-Beck disease (KBD) in clinical trials, but the evidence regarding the responsiveness of these instruments in KBD patients is limited. Therefore, the aim of this study was to evaluate and compare the responsiveness of the Chinese version of the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in KBD patients undergoing intra-articular injection of hyaluronic acid (HA).

METHODS

A sample of 232 KBD patients treated with intra-articular injection of HA completed the WOMAC, 12-item WHODAS 2.0 and joint dysfunction index (JDI) both pre- and post-treatment. Responsiveness was assessed using correlation and receiver operating characteristic (ROC) curve analyses following the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist.

RESULTS

Overall, there were significant improvements in the mean scores on the WOMAC and on the 12-item WHODAS 2.0, except for in the cognition domain. Correlation analysis showed that changes in the WOMAC and 12-item WHODAS 2.0 scores had moderate or weak positive associations with the changes in the JDI. However, acceptable areas under the ROC curve (value > 0.7) were found for all domains and for the total score on the WOMAC, but only for the mobility domain and the total score on the 12-item WHODAS 2.0.

CONCLUSIONS

These results demonstrated that the WOMAC was more responsive than the 12-item WHODAS 2.0 in KBD patients treated with intra-articular injection of HA. Our findings support the continued use of the WOMAC as an outcome measure in assessing disability in KBD patients.

Authors+Show Affiliations

School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China. School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region, Xi'an Jiaotong University, No.76 Yanta West Road, Xi'an, Shaanxi, 710061, People's Republic of China.School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.School of Nursing, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.School of Public Health, Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, Collaborative Innovation Center of Endemic Diseases and Health Promotion in Silk Road Region, Xi'an Jiaotong University, No.76 Yanta West Road, Xi'an, Shaanxi, 710061, People's Republic of China. guox@xjtu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32213176

Citation

Yang, Lei, et al. "Comparison of the Responsiveness of the WOMAC and the 12-item WHODAS 2.0 in Patients With Kashin-Beck Disease." BMC Musculoskeletal Disorders, vol. 21, no. 1, 2020, p. 188.
Yang L, Wang D, Li X, et al. Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin-Beck disease. BMC Musculoskelet Disord. 2020;21(1):188.
Yang, L., Wang, D., Li, X., Yuan, H., Fang, H., & Guo, X. (2020). Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin-Beck disease. BMC Musculoskeletal Disorders, 21(1), 188. https://doi.org/10.1186/s12891-020-03210-8
Yang L, et al. Comparison of the Responsiveness of the WOMAC and the 12-item WHODAS 2.0 in Patients With Kashin-Beck Disease. BMC Musculoskelet Disord. 2020 Mar 25;21(1):188. PubMed PMID: 32213176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the responsiveness of the WOMAC and the 12-item WHODAS 2.0 in patients with Kashin-Beck disease. AU - Yang,Lei, AU - Wang,Dimiao, AU - Li,Xiuxia, AU - Yuan,Hangjing, AU - Fang,Hua, AU - Guo,Xiong, Y1 - 2020/03/25/ PY - 2019/11/24/received PY - 2020/03/12/accepted PY - 2020/3/28/entrez PY - 2020/3/28/pubmed PY - 2020/3/28/medline KW - Kashin-Beck disease KW - Measurement properties KW - Responsiveness KW - WHODAS 2.0 KW - WOMAC SP - 188 EP - 188 JF - BMC musculoskeletal disorders JO - BMC Musculoskelet Disord VL - 21 IS - 1 N2 - BACKGROUND: Several questionnaires have been used to assess the health status of patients with Kashin-Beck disease (KBD) in clinical trials, but the evidence regarding the responsiveness of these instruments in KBD patients is limited. Therefore, the aim of this study was to evaluate and compare the responsiveness of the Chinese version of the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) in KBD patients undergoing intra-articular injection of hyaluronic acid (HA). METHODS: A sample of 232 KBD patients treated with intra-articular injection of HA completed the WOMAC, 12-item WHODAS 2.0 and joint dysfunction index (JDI) both pre- and post-treatment. Responsiveness was assessed using correlation and receiver operating characteristic (ROC) curve analyses following the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. RESULTS: Overall, there were significant improvements in the mean scores on the WOMAC and on the 12-item WHODAS 2.0, except for in the cognition domain. Correlation analysis showed that changes in the WOMAC and 12-item WHODAS 2.0 scores had moderate or weak positive associations with the changes in the JDI. However, acceptable areas under the ROC curve (value > 0.7) were found for all domains and for the total score on the WOMAC, but only for the mobility domain and the total score on the 12-item WHODAS 2.0. CONCLUSIONS: These results demonstrated that the WOMAC was more responsive than the 12-item WHODAS 2.0 in KBD patients treated with intra-articular injection of HA. Our findings support the continued use of the WOMAC as an outcome measure in assessing disability in KBD patients. SN - 1471-2474 UR - https://www.unboundmedicine.com/medline/citation/32213176/Comparison_of_the_responsiveness_of_the_WOMAC_and_the_12-item_WHODAS_2.0_in_patients_with_Kashin-Beck_disease L2 - https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-020-03210-8 DB - PRIME DP - Unbound Medicine ER -
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