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Covid-19 and the digestive system.
J Gastroenterol Hepatol. 2020 May; 35(5):744-748.JG

Abstract

The novel coronavirus disease is currently causing a major pandemic. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the Betacoronavirus genus that also includes the SARS-CoV and Middle East respiratory syndrome coronavirus. While patients typically present with fever and a respiratory illness, some patients also report gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. Studies have identified the SARS-CoV-2 RNA in stool specimens of infected patients, and its viral receptor angiotensin converting enzyme 2 was found to be highly expressed in gastrointestinal epithelial cells. These suggest that SARS-CoV-2 can actively infect and replicate in the gastrointestinal tract. This has important implications to the disease management, transmission, and infection control. In this article, we review the important gastrointestinal aspects of the disease.

Authors+Show Affiliations

Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.Institute of Digestive Disease, The Chinese University of Hong Kong, Shatin, Hong Kong. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32215956

Citation

Wong, Sunny H., et al. "Covid-19 and the Digestive System." Journal of Gastroenterology and Hepatology, vol. 35, no. 5, 2020, pp. 744-748.
Wong SH, Lui RN, Sung JJ. Covid-19 and the digestive system. J Gastroenterol Hepatol. 2020;35(5):744-748.
Wong, S. H., Lui, R. N., & Sung, J. J. (2020). Covid-19 and the digestive system. Journal of Gastroenterology and Hepatology, 35(5), 744-748. https://doi.org/10.1111/jgh.15047
Wong SH, Lui RN, Sung JJ. Covid-19 and the Digestive System. J Gastroenterol Hepatol. 2020;35(5):744-748. PubMed PMID: 32215956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Covid-19 and the digestive system. AU - Wong,Sunny H, AU - Lui,Rashid Ns, AU - Sung,Joseph Jy, Y1 - 2020/04/19/ PY - 2020/03/23/received PY - 2020/03/24/accepted PY - 2020/3/28/pubmed PY - 2020/5/7/medline PY - 2020/3/28/entrez KW - Covid-19 KW - coronavirus KW - diarrhea KW - gastrointestinal infection KW - pneumonia SP - 744 EP - 748 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 35 IS - 5 N2 - The novel coronavirus disease is currently causing a major pandemic. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the Betacoronavirus genus that also includes the SARS-CoV and Middle East respiratory syndrome coronavirus. While patients typically present with fever and a respiratory illness, some patients also report gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain. Studies have identified the SARS-CoV-2 RNA in stool specimens of infected patients, and its viral receptor angiotensin converting enzyme 2 was found to be highly expressed in gastrointestinal epithelial cells. These suggest that SARS-CoV-2 can actively infect and replicate in the gastrointestinal tract. This has important implications to the disease management, transmission, and infection control. In this article, we review the important gastrointestinal aspects of the disease. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/32215956/Covid_19_and_the_digestive_system_ L2 - https://doi.org/10.1111/jgh.15047 DB - PRIME DP - Unbound Medicine ER -