Tags

Type your tag names separated by a space and hit enter

SARS-CoV-2: a storm is raging.
J Clin Invest. 2020 05 01; 130(5):2202-2205.JCI

Abstract

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.

Links

Publisher Full Text
Aggregator Full Text

Authors

Pedersen SF
No affiliation info available
Ho YC
No affiliation info available

MeSH

Age FactorsBetacoronavirusCOVID-19Coronavirus InfectionsCytokinesDisease ProgressionHumansLymphocytesPandemicsPneumonia, ViralRespiratory Distress SyndromeSARS-CoV-2Severity of Illness Index

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32217834

Citation

Pedersen, Savannah F., and Ya-Chi Ho. "SARS-CoV-2: a Storm Is Raging." The Journal of Clinical Investigation, vol. 130, no. 5, 2020, pp. 2202-2205.
Pedersen SF, Ho YC. SARS-CoV-2: a storm is raging. J Clin Invest. 2020;130(5):2202-2205.
Pedersen, S. F., & Ho, Y. C. (2020). SARS-CoV-2: a storm is raging. The Journal of Clinical Investigation, 130(5), 2202-2205. https://doi.org/10.1172/JCI137647
Pedersen SF, Ho YC. SARS-CoV-2: a Storm Is Raging. J Clin Invest. 2020 05 1;130(5):2202-2205. PubMed PMID: 32217834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2: a storm is raging. AU - Pedersen,Savannah F, AU - Ho,Ya-Chi, PY - 2021/05/01/pmc-release PY - 2020/3/29/pubmed PY - 2020/5/7/medline PY - 2020/3/29/entrez KW - COVID-19 SP - 2202 EP - 2205 JF - The Journal of clinical investigation JO - J Clin Invest VL - 130 IS - 5 N2 - The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design. SN - 1558-8238 UR - https://www.unboundmedicine.com/medline/citation/32217834/SARS_CoV_2:_a_storm_is_raging_ L2 - https://doi.org/10.1172/JCI137647 DB - PRIME DP - Unbound Medicine ER -