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SARS-CoV-2: a storm is raging.
J Clin Invest. 2020 05 01; 130(5):2202-2205.JCI

Abstract

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32217834

Citation

Pedersen, Savannah F., and Ya-Chi Ho. "SARS-CoV-2: a Storm Is Raging." The Journal of Clinical Investigation, vol. 130, no. 5, 2020, pp. 2202-2205.
Pedersen SF, Ho YC. SARS-CoV-2: a storm is raging. J Clin Invest. 2020;130(5):2202-2205.
Pedersen, S. F., & Ho, Y. C. (2020). SARS-CoV-2: a storm is raging. The Journal of Clinical Investigation, 130(5), 2202-2205. https://doi.org/10.1172/JCI137647
Pedersen SF, Ho YC. SARS-CoV-2: a Storm Is Raging. J Clin Invest. 2020 05 1;130(5):2202-2205. PubMed PMID: 32217834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2: a storm is raging. AU - Pedersen,Savannah F, AU - Ho,Ya-Chi, PY - 2021/05/01/pmc-release PY - 2020/3/29/pubmed PY - 2020/5/7/medline PY - 2020/3/29/entrez KW - COVID-19 SP - 2202 EP - 2205 JF - The Journal of clinical investigation JO - J Clin Invest VL - 130 IS - 5 N2 - The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design. SN - 1558-8238 UR - https://www.unboundmedicine.com/medline/citation/32217834/SARS_CoV_2:_a_storm_is_raging_ L2 - https://doi.org/10.1172/JCI137647 DB - PRIME DP - Unbound Medicine ER -