Tags

Type your tag names separated by a space and hit enter

Colonic diverticular disease.
Nat Rev Dis Primers. 2020 03 26; 6(1):20.NR

Abstract

Diverticula are outpouchings of the intestinal wall and are common anatomical alterations detected in the human colon. Colonic diverticulosis (the presence of diverticula in the colon; referred to as diverticulosis) remains asymptomatic in most individuals but ~25% of individuals will develop symptomatic diverticulosis, termed colonic diverticular disease (also known as diverticular disease). Diverticular disease can range in severity from symptomatic uncomplicated diverticular disease (SUDD) to symptomatic disease with complications such as acute diverticulitis or diverticular haemorrhage. Since the early 2000s, a greater understanding of the pathophysiology of diverticulosis and diverticular disease, which encompasses genetic alterations, chronic low-grade inflammation and gut dysbiosis, has led to improvements in diagnosis and management. Diagnosis of diverticular disease relies on imaging approaches, such as ultrasonography, CT and MRI, as biomarkers alone are insufficient to establish a diagnosis despite their role in determining disease severity and progression as well as in differential diagnosis. Treatments for diverticular disease include dietary fibre, pharmacological treatments such as antibiotics (rifaximin), anti-inflammatory drugs (mesalazine) and probiotics, alone or in combination, and eventually surgery. Despite being effective in treating primary disease, their effectiveness in primary and secondary prevention of complications is still uncertain.

Authors+Show Affiliations

Territorial Gastroenterology Service, Azienda Sanitaria Locale Barletta-Andria-Trani, Andria, Italy. antotursi@tiscali.it.Faculty of Health Sciences, LUdeS Lugano Campus, Lugano, Switzerland. United Campus of Malta, Birkirkara, Msida, Malta.Division of Gastroenterology, Department of Medicine, Harborview Medical Center, University of Washington Medical School, Seattle, WA, USA.Service of Digestive Diseases, University Clinic Hospital Lozano Blesa, University of Zaragoza, IIS Aragón (CIBERehd), Zaragoza, Spain.Evangelisches Krankenhaus Kalk, Cologne, Germany.Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, affiliated with Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel.IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center - IRCCS -, Rozzano, Italy. Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

32218442

Citation

Tursi, Antonio, et al. "Colonic Diverticular Disease." Nature Reviews. Disease Primers, vol. 6, no. 1, 2020, p. 20.
Tursi A, Scarpignato C, Strate LL, et al. Colonic diverticular disease. Nat Rev Dis Primers. 2020;6(1):20.
Tursi, A., Scarpignato, C., Strate, L. L., Lanas, A., Kruis, W., Lahat, A., & Danese, S. (2020). Colonic diverticular disease. Nature Reviews. Disease Primers, 6(1), 20. https://doi.org/10.1038/s41572-020-0153-5
Tursi A, et al. Colonic Diverticular Disease. Nat Rev Dis Primers. 2020 03 26;6(1):20. PubMed PMID: 32218442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Colonic diverticular disease. AU - Tursi,Antonio, AU - Scarpignato,Carmelo, AU - Strate,Lisa L, AU - Lanas,Angel, AU - Kruis,Wolfgang, AU - Lahat,Adi, AU - Danese,Silvio, Y1 - 2020/03/26/ PY - 2020/02/11/accepted PY - 2020/3/29/entrez PY - 2020/3/29/pubmed PY - 2021/2/3/medline SP - 20 EP - 20 JF - Nature reviews. Disease primers JO - Nat Rev Dis Primers VL - 6 IS - 1 N2 - Diverticula are outpouchings of the intestinal wall and are common anatomical alterations detected in the human colon. Colonic diverticulosis (the presence of diverticula in the colon; referred to as diverticulosis) remains asymptomatic in most individuals but ~25% of individuals will develop symptomatic diverticulosis, termed colonic diverticular disease (also known as diverticular disease). Diverticular disease can range in severity from symptomatic uncomplicated diverticular disease (SUDD) to symptomatic disease with complications such as acute diverticulitis or diverticular haemorrhage. Since the early 2000s, a greater understanding of the pathophysiology of diverticulosis and diverticular disease, which encompasses genetic alterations, chronic low-grade inflammation and gut dysbiosis, has led to improvements in diagnosis and management. Diagnosis of diverticular disease relies on imaging approaches, such as ultrasonography, CT and MRI, as biomarkers alone are insufficient to establish a diagnosis despite their role in determining disease severity and progression as well as in differential diagnosis. Treatments for diverticular disease include dietary fibre, pharmacological treatments such as antibiotics (rifaximin), anti-inflammatory drugs (mesalazine) and probiotics, alone or in combination, and eventually surgery. Despite being effective in treating primary disease, their effectiveness in primary and secondary prevention of complications is still uncertain. SN - 2056-676X UR - https://www.unboundmedicine.com/medline/citation/32218442/Colonic_diverticular_disease_ L2 - https://doi.org/10.1038/s41572-020-0153-5 DB - PRIME DP - Unbound Medicine ER -