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Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan.
J Microbiol Immunol Infect. 2020 Jun; 53(3):459-466.JM

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CO-V-2), was first reported in Wuhan, Hubei province, China has now rapidly spread over 50 countries. For the prevention and control of infection, Taiwan Centers for Disease Control initiated testing of SARS-CoV-2 on January 24th 2020 for persons suspected with this disease. Until February 28th, 43 flu-like symptomatic patients were screened in China Medical University Hospital.

METHODS

Two patients were confirmed positive for SARS-CoV-2 infection by rRT-PCR as COVID-19 patients A and B. Causative pathogens for included patients were detected using FilmArray™ Respiratory Panel. We retrospectively analyzed the clinical presentations, laboratory data, radiologic findings, and travel and exposure contact histories, of the COVID-19 patients in comparison to those with other respiratory infections.

RESULTS

Through contact with Taiwan No. 19 case patient on 27th January, COVID-19 patients A and B were infected. Both patients had no identified comorbidities and developed mild illness with temporal fever, persistent cough, and lung interstitial infiltrates. Owing to the persistence of positive SARS-CoV-2 in respiratory specimen, the two COVID-19 patients are still in the isolation rooms despite recovery until 10th of March. The results of FilmArrayTM Respiratory Panel revealed 22 of the 41 non-COVID-19 patients were infected by particular pathogens. In general, seasonal respiratory pathogens are more prevalent than SARS-CoV-2 in symptomatic patients in non- COVID-19 endemic area during the flu season. Since all patients shared similar clinical and laboratory findings, expanded surveillance of detailed exposure history for suspected patients and application of rapid detection tools are highly recommended.

Links

Authors+Show Affiliations

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: kelly9502016@gmail.com.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan. Electronic address: d23214@mail.cmuh.org.tw.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Division of Pulmonary and Critical Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Division of Pulmonary and Critical Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Department of Laboratory Medicine, China Medical University Hospital, No. 2 Yu-Der Rd, North District, Taichung, Taiwan.

Division of Pediatric Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, Taiwan.

Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan; Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: yclai@csmu.edu.tw.

Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan. Electronic address: luminchi@outlook.com.

MeSH

BetacoronavirusCOVID-19Coronavirus InfectionsHumansMass ScreeningPandemicsPneumonia, ViralRetrospective StudiesSARS-CoV-2SeasonsTaiwanTravel

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32220574

Citation

Hsih, Wen-Hsin, et al. "Featuring COVID-19 Cases Via Screening Symptomatic Patients With Epidemiologic Link During Flu Season in a Medical Center of Central Taiwan." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 53, no. 3, 2020, pp. 459-466.

Hsih WH, Cheng MY, Ho MW, et al. Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan. J Microbiol Immunol Infect. 2020;53(3):459-466.

Hsih, W. H., Cheng, M. Y., Ho, M. W., Chou, C. H., Lin, P. C., Chi, C. Y., Liao, W. C., Chen, C. Y., Leong, L. Y., Tien, N., Lai, H. C., Lai, Y. C., & Lu, M. C. (2020). Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 53(3), 459-466. https://doi.org/10.1016/j.jmii.2020.03.008

Hsih WH, et al. Featuring COVID-19 Cases Via Screening Symptomatic Patients With Epidemiologic Link During Flu Season in a Medical Center of Central Taiwan. J Microbiol Immunol Infect. 2020;53(3):459-466. PubMed PMID: 32220574.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan. AU - Hsih,Wen-Hsin, AU - Cheng,Meng-Yu, AU - Ho,Mao-Wang, AU - Chou,Chia-Huei, AU - Lin,Po-Chang, AU - Chi,Chih-Yu, AU - Liao,Wei-Chih, AU - Chen,Chih-Yu, AU - Leong,Lih-Ying, AU - Tien,Ni, AU - Lai,Huan-Cheng, AU - Lai,Yi-Chyi, AU - Lu,Min-Chi, Y1 - 2020/03/13/ PY - 2020/03/08/received PY - 2020/03/10/revised PY - 2020/03/10/accepted PY - 2020/3/30/pubmed PY - 2020/6/17/medline PY - 2020/3/30/entrez KW - COVID-19 KW - FilmArray™ Respiratory Panel KW - SARS-CO-V-2 SP - 459 EP - 466 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 53 IS - 3 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CO-V-2), was first reported in Wuhan, Hubei province, China has now rapidly spread over 50 countries. For the prevention and control of infection, Taiwan Centers for Disease Control initiated testing of SARS-CoV-2 on January 24th 2020 for persons suspected with this disease. Until February 28th, 43 flu-like symptomatic patients were screened in China Medical University Hospital. METHODS: Two patients were confirmed positive for SARS-CoV-2 infection by rRT-PCR as COVID-19 patients A and B. Causative pathogens for included patients were detected using FilmArray™ Respiratory Panel. We retrospectively analyzed the clinical presentations, laboratory data, radiologic findings, and travel and exposure contact histories, of the COVID-19 patients in comparison to those with other respiratory infections. RESULTS: Through contact with Taiwan No. 19 case patient on 27th January, COVID-19 patients A and B were infected. Both patients had no identified comorbidities and developed mild illness with temporal fever, persistent cough, and lung interstitial infiltrates. Owing to the persistence of positive SARS-CoV-2 in respiratory specimen, the two COVID-19 patients are still in the isolation rooms despite recovery until 10th of March. The results of FilmArrayTM Respiratory Panel revealed 22 of the 41 non-COVID-19 patients were infected by particular pathogens. In general, seasonal respiratory pathogens are more prevalent than SARS-CoV-2 in symptomatic patients in non- COVID-19 endemic area during the flu season. Since all patients shared similar clinical and laboratory findings, expanded surveillance of detailed exposure history for suspected patients and application of rapid detection tools are highly recommended. SN - 1995-9133 UR - https://www.unboundmedicine.com/medline/citation/32220574/Featuring_COVID_19_cases_via_screening_symptomatic_patients_with_epidemiologic_link_during_flu_season_in_a_medical_center_of_central_Taiwan_ DB - PRIME DP - Unbound Medicine ER -