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Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19.
J Med Virol. 2020 07; 92(7):726-730.JM

Abstract

This article reviews the correlation between angiotensin-converting enzyme 2 (ACE2) and severe risk factors for coronavirus disease 2019 (COVID-19) and the possible mechanisms. ACE2 is a crucial component of the renin-angiotensin system (RAS). The classical RAS ACE-Ang II-AT1R regulatory axis and the ACE2-Ang 1-7-MasR counter-regulatory axis play an essential role in maintaining homeostasis in humans. ACE2 is widely distributed in the heart, kidneys, lungs, and testes. ACE2 antagonizes the activation of the classical RAS system and protects against organ damage, protecting against hypertension, diabetes, and cardiovascular disease. Similar to SARS-CoV, SARS-CoV-2 also uses the ACE2 receptor to invade human alveolar epithelial cells. Acute respiratory distress syndrome (ARDS) is a clinical high-mortality disease, and ACE2 has a protective effect on this type of acute lung injury. Current research shows that the poor prognosis of patients with COVID-19 is related to factors such as sex (male), age (>60 years), underlying diseases (hypertension, diabetes, and cardiovascular disease), secondary ARDS, and other relevant factors. Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein-based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the future.

Authors+Show Affiliations

Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China.Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China.Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China. The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China. Department of Liver Diseases, Peking University International Hospital, Beijing, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32221983

Citation

Cheng, Hao, et al. "Organ-protective Effect of Angiotensin-converting Enzyme 2 and Its Effect On the Prognosis of COVID-19." Journal of Medical Virology, vol. 92, no. 7, 2020, pp. 726-730.
Cheng H, Wang Y, Wang GQ. Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. J Med Virol. 2020;92(7):726-730.
Cheng, H., Wang, Y., & Wang, G. Q. (2020). Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. Journal of Medical Virology, 92(7), 726-730. https://doi.org/10.1002/jmv.25785
Cheng H, Wang Y, Wang GQ. Organ-protective Effect of Angiotensin-converting Enzyme 2 and Its Effect On the Prognosis of COVID-19. J Med Virol. 2020;92(7):726-730. PubMed PMID: 32221983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. AU - Cheng,Hao, AU - Wang,Yan, AU - Wang,Gui-Qiang, Y1 - 2020/04/05/ PY - 2020/03/12/received PY - 2020/03/20/revised PY - 2020/03/24/accepted PY - 2020/3/30/pubmed PY - 2020/6/25/medline PY - 2020/3/30/entrez KW - acute respiratory distress syndrome (ARDS) KW - angiotensin-converting enzyme 2 (ACE2) KW - coronavirus disease 2019 (COVID-19) KW - renin-angiotensin system (RAS) KW - severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) SP - 726 EP - 730 JF - Journal of medical virology JO - J. Med. Virol. VL - 92 IS - 7 N2 - This article reviews the correlation between angiotensin-converting enzyme 2 (ACE2) and severe risk factors for coronavirus disease 2019 (COVID-19) and the possible mechanisms. ACE2 is a crucial component of the renin-angiotensin system (RAS). The classical RAS ACE-Ang II-AT1R regulatory axis and the ACE2-Ang 1-7-MasR counter-regulatory axis play an essential role in maintaining homeostasis in humans. ACE2 is widely distributed in the heart, kidneys, lungs, and testes. ACE2 antagonizes the activation of the classical RAS system and protects against organ damage, protecting against hypertension, diabetes, and cardiovascular disease. Similar to SARS-CoV, SARS-CoV-2 also uses the ACE2 receptor to invade human alveolar epithelial cells. Acute respiratory distress syndrome (ARDS) is a clinical high-mortality disease, and ACE2 has a protective effect on this type of acute lung injury. Current research shows that the poor prognosis of patients with COVID-19 is related to factors such as sex (male), age (>60 years), underlying diseases (hypertension, diabetes, and cardiovascular disease), secondary ARDS, and other relevant factors. Because of these protective effects of ACE2 on chronic underlying diseases and ARDS, the development of spike protein-based vaccine and drugs enhancing ACE2 activity may become one of the most promising approaches for the treatment of COVID-19 in the future. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/32221983/Organ_protective_effect_of_angiotensin_converting_enzyme_2_and_its_effect_on_the_prognosis_of_COVID_19_ L2 - https://doi.org/10.1002/jmv.25785 DB - PRIME DP - Unbound Medicine ER -