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Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia.
J Med Virol. 2020 07; 92(7):909-914.JM

Abstract

Coronavirus Disease 2019 (COVID-19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After its first occurrence in Wuhan of China from December 2019, COVID-19 rapidly spread around the world. According to the World Health Organization statement on 13 March 2020, there had been over 132 500 confirmed cases globally. Nevertheless, the case reports of children are rare, which results in the lack of evidence for preventing and controlling of children's infection. Here, we report three cases of SARS-CoV-2 infected children diagnosed from 3 February to 17 February 2020 in Tianjin, China. All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. However, after been discharged, all three cases were tested SARS-CoV-2 positive in the stool samples within 10 days, in spite of their remained negative nucleic acid in throat swab specimens. Therefore, it is necessary to be aware of the possibility of fecal-oral transmission of SARS-CoV-2 infection, especially for children cases.

Authors+Show Affiliations

Department of Respiratory, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China. Graduate School of Tianjin Medical University, Tianjin, China.Department of Clinical Laboratory, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.Department of Clinical Laboratory, Shenyang Coloproctology Hospital, Liaoning, China.Department of Neonatal Surgery, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.Department of Respiratory, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.Department of Imaging, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.Department of Respiratory, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.Department of Neurosurgery, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia.Department of Respiratory, The Children's Hospital of Tianjin (Children's Hospital of Tianjin University), Tianjin, China.

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32222992

Citation

Zhang, Tongqiang, et al. "Detectable SARS-CoV-2 Viral RNA in Feces of Three Children During Recovery Period of COVID-19 Pneumonia." Journal of Medical Virology, vol. 92, no. 7, 2020, pp. 909-914.
Zhang T, Cui X, Zhao X, et al. Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia. J Med Virol. 2020;92(7):909-914.
Zhang, T., Cui, X., Zhao, X., Wang, J., Zheng, J., Zheng, G., Guo, W., Cai, C., He, S., & Xu, Y. (2020). Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia. Journal of Medical Virology, 92(7), 909-914. https://doi.org/10.1002/jmv.25795
Zhang T, et al. Detectable SARS-CoV-2 Viral RNA in Feces of Three Children During Recovery Period of COVID-19 Pneumonia. J Med Virol. 2020;92(7):909-914. PubMed PMID: 32222992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detectable SARS-CoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia. AU - Zhang,Tongqiang, AU - Cui,Xiaojian, AU - Zhao,Xue, AU - Wang,Jinhu, AU - Zheng,Jiafeng, AU - Zheng,Guifen, AU - Guo,Wei, AU - Cai,Chunquan, AU - He,Sijia, AU - Xu,Yongsheng, Y1 - 2020/04/15/ PY - 2020/03/14/received PY - 2020/03/23/accepted PY - 2020/3/31/pubmed PY - 2020/6/25/medline PY - 2020/3/31/entrez KW - COVID-19 KW - SARS-CoV-2 KW - children KW - clinical characteristics SP - 909 EP - 914 JF - Journal of medical virology JO - J. Med. Virol. VL - 92 IS - 7 N2 - Coronavirus Disease 2019 (COVID-19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After its first occurrence in Wuhan of China from December 2019, COVID-19 rapidly spread around the world. According to the World Health Organization statement on 13 March 2020, there had been over 132 500 confirmed cases globally. Nevertheless, the case reports of children are rare, which results in the lack of evidence for preventing and controlling of children's infection. Here, we report three cases of SARS-CoV-2 infected children diagnosed from 3 February to 17 February 2020 in Tianjin, China. All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. However, after been discharged, all three cases were tested SARS-CoV-2 positive in the stool samples within 10 days, in spite of their remained negative nucleic acid in throat swab specimens. Therefore, it is necessary to be aware of the possibility of fecal-oral transmission of SARS-CoV-2 infection, especially for children cases. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/32222992/Detectable_SARS_CoV_2_viral_RNA_in_feces_of_three_children_during_recovery_period_of_COVID_19_pneumonia_ L2 - https://doi.org/10.1002/jmv.25795 DB - PRIME DP - Unbound Medicine ER -