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The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications.
Biochem Pharmacol. 2020 06; 176:113931.BP

Abstract

Nitric oxide (NO) and hydrogen sulfide (H2S) are industrial toxins or pollutants; however, both are produced endogenously and have important biological roles in most mammalian tissues. The recognition that these gasotransmitters have a role in physiological and pathophysiological processes has presented opportunities to harness their intracellular effects either through inhibition of their production; or more commonly, through inducing their levels and or delivering them by various modalities. In this review article, we have focused on an array of NO and H2S donors, their hybrids with other established classes of drugs, and the various engineered delivery platforms such a fibers, polymers, nanoparticles, hydrogels, and others. In each case, we have reviewed the rationale for their development.

Authors+Show Affiliations

Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA.Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA.Department of Chemistry and Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA. Electronic address: jbmatson@vt.edu.Department of Molecular, Cellular, and Biomedical Sciences, Sophie Davis School of Biomedical Education, City University of New York School of Medicine, 160 Convent Avenue, New York, NY 10031, USA; Graduate Program in Biology, City University of New York Graduate Center, NY, USA. Electronic address: kashfi@med.cuny.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

32224139

Citation

Dillon, Kearsley M., et al. "The Evolving Landscape for Cellular Nitric Oxide and Hydrogen Sulfide Delivery Systems: a New Era of Customized Medications." Biochemical Pharmacology, vol. 176, 2020, p. 113931.
Dillon KM, Carrazzone RJ, Matson JB, et al. The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications. Biochem Pharmacol. 2020;176:113931.
Dillon, K. M., Carrazzone, R. J., Matson, J. B., & Kashfi, K. (2020). The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications. Biochemical Pharmacology, 176, 113931. https://doi.org/10.1016/j.bcp.2020.113931
Dillon KM, et al. The Evolving Landscape for Cellular Nitric Oxide and Hydrogen Sulfide Delivery Systems: a New Era of Customized Medications. Biochem Pharmacol. 2020;176:113931. PubMed PMID: 32224139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications. AU - Dillon,Kearsley M, AU - Carrazzone,Ryan J, AU - Matson,John B, AU - Kashfi,Khosrow, Y1 - 2020/03/26/ PY - 2020/01/15/received PY - 2020/03/20/accepted PY - 2020/4/1/pubmed PY - 2020/10/27/medline PY - 2020/4/1/entrez KW - Delivery platforms KW - Fibers KW - H(2)S-releasing hybrids KW - Hydrogels KW - Hydrogen sulfide KW - NO-releasing compounds KW - Nanoparticles KW - Nitric oxide KW - Polymers SP - 113931 EP - 113931 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 176 N2 - Nitric oxide (NO) and hydrogen sulfide (H2S) are industrial toxins or pollutants; however, both are produced endogenously and have important biological roles in most mammalian tissues. The recognition that these gasotransmitters have a role in physiological and pathophysiological processes has presented opportunities to harness their intracellular effects either through inhibition of their production; or more commonly, through inducing their levels and or delivering them by various modalities. In this review article, we have focused on an array of NO and H2S donors, their hybrids with other established classes of drugs, and the various engineered delivery platforms such a fibers, polymers, nanoparticles, hydrogels, and others. In each case, we have reviewed the rationale for their development. SN - 1873-2968 UR - https://www.unboundmedicine.com/medline/citation/32224139/The_evolving_landscape_for_cellular_nitric_oxide_and_hydrogen_sulfide_delivery_systems:_A_new_era_of_customized_medications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(20)30159-3 DB - PRIME DP - Unbound Medicine ER -