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Cyclosomatostatin-induced catalepsy in aged rats: Specific change of brain c-Fos protein expression in the lateral entorhinal cortex.
Brain Res Bull. 2020 Jun; 159:79-86.BR

Abstract

Aging represents the largest risk factor for developing Parkinson's disease (PD); another salient feature of this disorder is a decreased brain levels of somatostatin. Recently, in aged Wistar rats, we simulated the central somatostatinergic deficiency by intracerebroventricular injections of a somatostatin antagonist, cyclosomatostatin (cSST). The treated animals displayed catalepsy, a state that resembles the extrapyramidal signs of Parkinson's disease; young animals were insensitive to cSST. The neuroanatomical substrates responsible for the increased cataleptogenic activity of cSST in aged animals, are currently unknown. To study this issue, we assessed the cSST effect on brain c-Fos-protein expression in aged and young rats; thirty three brain regions were examined. cSST was employed at the dose cataleptogenic for aged animals and non-cataleptogenic for young ones. c-Fos expression patterns in the 'cataleptic' and 'non-cataleptic' animals were very similar, with the only distinction being a decrease in the c-Fos expression in the aged lateral entorhinal cortex (LEntCx). This decrease was not observed when the cSST-induced cataleptic response was inhibited by administration of diphenhydramine and nicotine. Thus, the development of catalepsy in the aged Wistar rats appeared to be associated with a hypoactivation of the LEntCx; possibly, there exists a mechanistic link between the LEntCx hypoactivation and increased susceptibility of aged rats to catalepsy. Apparently, these findings may provide novel insight into the link between mechanisms of parkinsonian motor disorders and aging.

Authors+Show Affiliations

Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia. Electronic address: newrology@yandex.ru.Timpharm LTD, Moscow, Russia.Timpharm LTD, Moscow, Russia.Timpharm LTD, Moscow, Russia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32224159

Citation

Ionov, Ilya D., et al. "Cyclosomatostatin-induced Catalepsy in Aged Rats: Specific Change of Brain c-Fos Protein Expression in the Lateral Entorhinal Cortex." Brain Research Bulletin, vol. 159, 2020, pp. 79-86.
Ionov ID, Pushinskaya II, Gorev NP, et al. Cyclosomatostatin-induced catalepsy in aged rats: Specific change of brain c-Fos protein expression in the lateral entorhinal cortex. Brain Res Bull. 2020;159:79-86.
Ionov, I. D., Pushinskaya, I. I., Gorev, N. P., & Frenkel, D. D. (2020). Cyclosomatostatin-induced catalepsy in aged rats: Specific change of brain c-Fos protein expression in the lateral entorhinal cortex. Brain Research Bulletin, 159, 79-86. https://doi.org/10.1016/j.brainresbull.2020.03.013
Ionov ID, et al. Cyclosomatostatin-induced Catalepsy in Aged Rats: Specific Change of Brain c-Fos Protein Expression in the Lateral Entorhinal Cortex. Brain Res Bull. 2020;159:79-86. PubMed PMID: 32224159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cyclosomatostatin-induced catalepsy in aged rats: Specific change of brain c-Fos protein expression in the lateral entorhinal cortex. AU - Ionov,Ilya D, AU - Pushinskaya,Irina I, AU - Gorev,Nicholas P, AU - Frenkel,David D, Y1 - 2020/03/26/ PY - 2019/10/01/received PY - 2020/02/19/revised PY - 2020/03/21/accepted PY - 2020/4/1/pubmed PY - 2020/4/1/medline PY - 2020/4/1/entrez KW - Aging KW - Catalepsy KW - Cyclosomatostatin KW - Lateral entorhinal cortex KW - Parkinson’s disease KW - c-Fos protein SP - 79 EP - 86 JF - Brain research bulletin JO - Brain Res. Bull. VL - 159 N2 - Aging represents the largest risk factor for developing Parkinson's disease (PD); another salient feature of this disorder is a decreased brain levels of somatostatin. Recently, in aged Wistar rats, we simulated the central somatostatinergic deficiency by intracerebroventricular injections of a somatostatin antagonist, cyclosomatostatin (cSST). The treated animals displayed catalepsy, a state that resembles the extrapyramidal signs of Parkinson's disease; young animals were insensitive to cSST. The neuroanatomical substrates responsible for the increased cataleptogenic activity of cSST in aged animals, are currently unknown. To study this issue, we assessed the cSST effect on brain c-Fos-protein expression in aged and young rats; thirty three brain regions were examined. cSST was employed at the dose cataleptogenic for aged animals and non-cataleptogenic for young ones. c-Fos expression patterns in the 'cataleptic' and 'non-cataleptic' animals were very similar, with the only distinction being a decrease in the c-Fos expression in the aged lateral entorhinal cortex (LEntCx). This decrease was not observed when the cSST-induced cataleptic response was inhibited by administration of diphenhydramine and nicotine. Thus, the development of catalepsy in the aged Wistar rats appeared to be associated with a hypoactivation of the LEntCx; possibly, there exists a mechanistic link between the LEntCx hypoactivation and increased susceptibility of aged rats to catalepsy. Apparently, these findings may provide novel insight into the link between mechanisms of parkinsonian motor disorders and aging. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/32224159/Cyclosomatostatin-induced_catalepsy_in_aged_rats:_Specific_change_of_brain_c-Fos_protein_expression_in_the_lateral_entorhinal_cortex L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(19)30773-7 DB - PRIME DP - Unbound Medicine ER -
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